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172 cs: Mikrogranulární varianta APL
en: Microgranular variant APL 		10 A. Buliková, J. Kissová 21.7.2008, 17:58 9.9.2009, 21:29 9.9.2009, 21:29 J. Kissová
147 cs: Chronická myeloidní leukémie - akcelerace onemocnění
en: Chronic myelogenous leukaemia - accelerated phase 		7 Irena Trnavská, J. Kissová 3.5.2008, 21:08 9.9.2009, 23:06 9.9.2009, 23:06 J. Kissová
44 cs: Chronická myeloidní leukémie - chronická fáze
en: Chronic myelogenous leukaemia - chronic phase 		4 A. Buliková 8.12.2006, 20:03 2.10.2007, 13:11 2.10.2007, 13:11 J. Kissová


Nalezené obrázky* (n=56)

AML without maturation- BM- MPOX
There are the most negative cells in myeloperoxidase staining. But three immature cells in the picture (at left) are cleary positive. One positive cell at right is more mature (metamyelocyte or even band) and cannot be count in numer of positive blasts. / Většina buněk je negativní v barvení myeloperoxidázy. Ale tři nezralé buňky na obrázku (vlevo) jsou jasně pozitivní. Jedna pozitivní buňka vpravo je více zralá (metamyelocyt nebo dokonce tyčka) a nemůže být započtena do počtu pozitivních blastů. Description: There are the most negative cells in myeloperoxidase staining. But three immature cells in the picture (at left) are cleary positive. One positive cell at right is more mature (metamyelocyte or even band) and cannot be count in numer of positive blasts.
Type: bone marrow
Klíčová slova*: myeloblast, metamyelocyte, band, myeloperoxidase stain
AML without maturation- BM
Bone marrow is rich and infiltrated by uniform population of myeloblasts. There are only two lymphocytes (in the middle and at 6 o'clock) there; they can be distinguished by mature chromatin and markable smaller cell¨s size. One promyelocyte - large cell, ex-centric nucleus, numerous azurophilic granulation - is at the bottom of the picture (8 o'clock). / Kostní dřeň je bohatá a infiltrovaná uniformní populací myeloblastů. Jsou zde jen dva lymfocyty (uprostřed a na 6. hodině); tyto mohou být odlišeny podle zralého chromatinu a zřetelně menší velikosti buňky. Jeden promyelocyt - větší buňka, excentrické jádro, početná azurofilní granulace - je v dolní části obrázku (na 8. hodině). Description: Bone marrow is rich and infiltrated by uniform population of myeloblasts. There are only two lymphocytes (in the middle and at 6 o'clock) there; they can be distinguished by mature chromatin and markable smaller cell¨s size. One promyelocyte - large cell, ex-centric nucleus, numerous azurophilic granulation - is at the bottom of the picture (8 o'clock).
Type: bone marrow
Klíčová slova*: myeloblast, promyelocyte, lymphocyte
AML with multilineage dysplasia - PB
Peripheral blood smears show 27% of myeloblasts (upper right) but also some other cells of granulocytic lineage - there is myelocyte at the lower left. / Nátěr periferní krve ukazuje 27% myeloblastů (nahoře vpravo), ale také jiné buňky granulocytární řady - vlevo dole je myelocyt. Description: Peripheral blood smears show 27% of myeloblasts (upper right) but also some other cells of granulocytic lineage - there is myelocyte at the lower left.
Type: peripheral blood
Klíčová slova*: myeloblast, myelocyte
AML with multilineage dysplasia - BM
Three myeloblasts are in the lower left; one of them (underneath eosinophilic myelocyte) has some azurophilic granulation, cytoplasmic protrusions and cleft nucleus. Erythroid lineage shows dysplastic features - nuclear lobulisation, karyorhexis and poor hemoglobinization of cytoplasm. / Tři myeloblasty jsou vlevo dole, jeden z nich (pod eozinofilním myelocytem) má nějakou azurofilní granulace, cytoplazmatické výběžky a rozštěpené jádro. Erytroidní linie vykazuje dysplastické rysy - lobulizaci jádra, karyorhexi a špatnou hemoglobinizaci cytoplazmy. Description: Three myeloblasts are in the lower left; one of them (underneath eosinophilic myelocyte) has some azurophilic granulation, cytoplasmic protrusions and cleft nucleus. Erythroid lineage shows dysplastic features - nuclear lobulisation, karyorhexis and poor hemoglobinization of cytoplasm.
Type: bone marrow
Klíčová slova*: myeloblast, eosinophil
microgranular variant APL- BM
Four tumour cells in variant APL with bi-lobar nuclei, rather fine cytoplasmic granulation and cytoplasmic projections at the outline of the cell. There is one typical hypergranular promyelocyte at the upper left with cytoplasm filed by large numerous azurophilic granules, which totally obscure the nuclear cytoplasmic margin. / Čtyři nádorové buňky u varinatní APL s bilobárními jádry, spíše jemnou cytoplazmatickou granulací a cytoplazmatickými výběžky na zevním obvodu buňky. Jeden typický hypergranulární promyelocyt je nahoře vlevo s cytoplazmou naplněnou velkými početnými azurofilními granuly, která úplně zakrývají rozhraní mezi jádrem a cytoplazmou. Description: Four tumour cells in variant APL with bi-lobar nuclei, rather fine cytoplasmic granulation and cytoplasmic projections at the outline of the cell. There is one typical hypergranular promyelocyte at the upper left with cytoplasm filed by large numerous azurophilic granules, which totally obscure the nuclear cytoplasmic margin.
Type: bone marrow
Klíčová slova*: promyelocyte
microgranular variant APL- BM
In all cases of acute leukaemia with bilobar nuclei it is really necessary carefully search for cells with bundles Auer rods in cytoplasm ("faggot cells"). This finding brings high suspicion to diagnose of microgranular variant of APL, which should be confirmed by cytogenetic and/or molecular genetic examination - presence of t(15;17) and/or PML/RARalfa fusion gene. / Ve všech případech akutní leukémie s bilobárními jádry je opravdu nezbytné pečlivě pátrat po buňkách se snopci Auerových tyčí v cytoplazmě ("faggot cells"). Tento nález přináší vysoké podezření na diagnózu mikrogranulární varianty APL, která by měla být potvrzena cytogenatickým a/nebo molekulárně genatickým vyšetřením - přítomnost t(15;17) a/nebo PML/RARalfa fúzního genu. Description: In all cases of acute leukaemia with bilobar nuclei it is really necessary carefully search for cells with bundles Auer rods in cytoplasm ("faggot cells"). This finding brings high suspicion to diagnose of microgranular variant of APL, which should be confirmed by cytogenetic and/or molecular genetic examination - presence of t(15;17) and/or PML/RARalfa fusion gene.
Type: bone marrow
Klíčová slova*: promyelocyte, Auer rod, faggot cell
microgranular variant APL- BM
Bi-lobular or multilobular (cell at the middle right) nuclei and fine reddish granulation in cytoplasm are also typical in tumour cells in bone marrow. / Bilobární nebo multilobulární (buňka ve středu vpravo) jádra a jemná načervenalá granulace v cytoplazmy jsou typické taktéž v nádorových buňkách kostní dřeně. Description: Bi-lobular or multilobular (cell at the middle right) nuclei and fine reddish granulation in cytoplasm are also typical in tumour cells in bone marrow.
Type: bone marrow
Klíčová slova*: promyelocyte
microgranular variant APL- PB
Numerous bi-lobar or kidney shaped nuclei and agranular or fine granular cytoplasm in "promyelocytes" in peripheral blood smears in patient with AML M3v. Cytoplasm of some cells (example at upper left) can contain more pronounced usually isolated red inclusion. / Početná bilobární či ledvinovitá jádra a agranulární či jemně granulovavaná cytoplazma v "promyelocytech" nátěru periferního krvi u pacienta s AML M3v. Cytoplazma některých buněk (příklad vlevo nahoře) mohou obsahovat více vyjádřené obvykle izolované červené inkluze. Description: Numerous bi-lobar or kidney shaped nuclei and agranular or fine granular cytoplasm in "promyelocytes" in peripheral blood smears in patient with AML M3v. Cytoplasm of some cells (example at upper left) can contain more pronounced usually isolated red inclusion.
Type: peripheral blood
Klíčová slova*: promyelocyte
microgranular variant APL- PB
Bi-lobar nucleus and clear Auer rod but in almost agranular cytoplasm are typical features in the cell at upper left. Two large lobes of nucleus joined by a narrow bridge (cell at the 3 o'clock) present another characteristics of the variant form PML. / Bilobární jádro a jasná Auerova tyč, ale v téměř agranulární cytoplazmě, jsou typické známky v buňce nahoře vlevo. Dva velké laloky jádra spojené tenkým můstkem (buňka na 3. hodině) představují jiné charakteristické rysy variantní formy PML. Description: Bi-lobar nucleus and clear Auer rod but in almost agranular cytoplasm are typical features in the cell at upper left. Two large lobes of nucleus joined by a narrow bridge (cell at the 3 o'clock) present another characteristics of the variant form PML.
Type: peripheral blood
Klíčová slova*: promyelocyte
microgranular variant APL- PB
Tumour cell with bi-lobar nucleus, clear nucleoli in every nuclear part, some (upper left) or no (lower right) cytoplasmic granulation. / Nádorové buňky s bilobárním jádrem, jasnými jadérky v každé části jádra, nějakou (vlevo nahoře) nebo žádnou (vpravo dole) cytoplazmatickou granulací. Description: Tumour cell with bi-lobar nucleus, clear nucleoli in every nuclear part, some (upper left) or no (lower right) cytoplasmic granulation.
Type: peripheral blood
Klíčová slova*: promyelocyte, tumour cell
microgranular variant APL- PB
Some pathological promyelocytes are completely agranular (lower left) with kidney shaped nucleus. Some Auer rods even in bundles can be find almost in every cases - in this one there are 3-4 thick Auer rods in the second cell from bellow at right. / Některé patologické promyelocyty jsou úplně agranulární (vlevo dole) s ledvinovým tvarem jádra. Auerovy tyče dokonce ve snopcích mohou být nalezeny téměř ve všech případech - v tomto jsou 3-4 silné Auerovy tyče ve druhé buňce zespodu vpravo. Description: Some pathological promyelocytes are completely agranular (lower left) with kidney shaped nucleus. Some Auer rods even in bundles can be find almost in every cases - in this one there are 3-4 thick Auer rods in the second cell from bellow at right.
Type: peripheral blood
Klíčová slova*: promyelocyte, Auer rod
microgranular variant APL-PB
The main feature of this type acute myeloblastic leukaemia is bi-lobed nuclear shape and presence of dust-like reddish granules in cytoplasm. Some tumour cells can be even agranular. Leukocytosis is usual when one compares this type with classic hyper-granular form. / Hlavním rysem tohoto typu akutní myeloblastické leukémie je bilobární tvar jádra a přítomnost prachových načervenalých granulí v cytoplazmě. Některé nádorové buňky mohou být dokonce agranulární. Leukocytóza je obvykla v porovnání s klasickou hypergranulární variantou. Description: The main feature of this type acute myeloblastic leukaemia is bi-lobed nuclear shape and presence of dust-like reddish granules in cytoplasm. Some tumour cells can be even agranular. Leukocytosis is usual when one compares this type with classic hyper-granular form.
Type: peripheral blood
Klíčová slova*: promyelocyte, tumour cell
Anaplastic large cell lymphoma - ALK negative
Tumour cells can be smaller in lymphohistiocytic variant of ALCL - in this case malignant lymphoma cell has cleft or bi-lobar nucleus, abundant vacuolized cytoplasm and cytoplasmic blebs; it is almost comparable in size with immature myelocyte on it's left (both cell at upper right). / Nádorové buňky mohou být u lymfohistiocytární varianty ALCL menší - v tomto případě má buňka maligního lymfomu rozštěpené nebo bilobární jádro, bohatou vakuolizovanou cytoplazmu a cytoplazmatické "blebs"; je téměř srovnatel´co do velikosti s nezralým myelocytem po její levé straně (obě buňky vpravo nahoře). Description: Tumour cells can be smaller in lymphohistiocytic variant of ALCL - in this case malignant lymphoma cell has cleft or bi-lobar nucleus, abundant vacuolized cytoplasm and cytoplasmic blebs; it is almost comparable in size with immature myelocyte on it's left (both cell at upper right).
Type: bone marrow
Klíčová slova*: myelocyte, tumour cell
Medulloblastom
BM metastasis.Large cluster of malignant cells with polymorphic cellular and nuclear shape and size.Nuclei rather eccentrically located, irregular or lobed, some with large nuclei.Marked vacuoles of basophilic cytoplasm and also of some of the nuclei.Left upper part of the picture shows a segmented neutrophile and a hypogranular myelocyte. / Metastáza v KD.Velký shluk maligních buněk, zřetelná polymorfie tvaru a velikosti buněk i jader,zejména ve srovnání s neuroblastomem. Jádra spíše excentricky uložena,nepravidel- ná,až laločnatá,oj.s velkými jadérky.Cytoplasma basofilní, výrazně vakuolizovaná,částečně i vakuolizace jader.Vlevo nahoře segmentovaný neutrofil a hypogranulární myeolocyt. Description: BM metastasis.Large cluster of malignant cells with polymorphic cellular and nuclear shape and size.Nuclei rather eccentrically located, irregular or lobed, some with large nuclei.Marked vacuoles of basophilic cytoplasm and also of some of the nuclei.Left upper part of the picture shows a segmented neutrophile and a hypogranular myelocyte.
Type: bone marrow
Klíčová slova*: tumour cell
Anaplastic large cell lymphoma - ALK negative
Three tumour cells in ALCL. They have pale basophilic cytoplasm, fine reticular nuclear chromatin and few dark blue nucleoli. There are two nuclear fragments in cytoplasm one of them (upper left). At the upper right are two immature neutrophils (upper promyelocyte, lower myelocyte). / Tři nádorové buňky u ALCL. Mají světle bazofilní cytoplazmu, jemný síťovitý jaderný chromatin a několik tmavě modrých jadérek. V cytoplazmě jedné z nich jsou dva jaderné fragmenty (nahoře vlevo). Nahoře vpravo jsou dva nezralé neutrofily (horní promyelocyt, dolní myelocyt). Description: Three tumour cells in ALCL. They have pale basophilic cytoplasm, fine reticular nuclear chromatin and few dark blue nucleoli. There are two nuclear fragments in cytoplasm one of them (upper left). At the upper right are two immature neutrophils (upper promyelocyte, lower myelocyte).
Type: bone marrow
Klíčová slova*: promyelocyte, myelocyte, tumour cell
Anaplastic large cell lymphoma - ALK negative
One tumour cell in ALCL (middle right) - large cell with fine nuclear chromatin, prominent nucleolus, abundant cytoplasm which basophilia passes to eosinophilia. There are also three neutrophil myelocytes (upper one is destroyed), one lymphocyte (at 3 o'clock). The last cell in the picture is macrophage (between two myelocytes). These cells are typical component of this lymphohistiocytic variant of the lymphoma . / Jedna nádorová buňka u ALCL (ve středu vpravo) - velká buňka s jemným jaderným chromatinem, prominujícím jadérkem, bohatou cytoplazmou jejíž basofilie přechází do eozinofilie. Také jsou zde tři neutrofilní myelocyty (horní je poškozený), jeden lymfocyt (na 3. hodině). Poslední buňkou na obrázku je makrofág (mezi dvěma myelocyty). Tyto buňky jsou typickou součástí této lymfohistiocytární varianty lymfomu. Description: One tumour cell in ALCL (middle right) - large cell with fine nuclear chromatin, prominent nucleolus, abundant cytoplasm which basophilia passes to eosinophilia. There are also three neutrophil myelocytes (upper one is destroyed), one lymphocyte (at 3 o'clock). The last cell in the picture is macrophage (between two myelocytes). These cells are typical component of this lymphohistiocytic variant of the lymphoma .
Type: bone marrow
Klíčová slova*: myelocyte, macrophage, tumour cell
Chronic myelogenous leukaemia - chronic phase
Various stages of maturation in neutrophil lineage (one myeloblast in the centre, two segments and metamyelocyte). Only one early normoblast is under the myeloblast; beside it to the left is basophil. / Různá stádia vyzrávání v neutrofilní řadě (jeden myeloblast v centru, dva segmenty a metamyelocyt). Jen jeden časný normoblast je pod myeloblastem, vedle něj doleva je basofil. Description: Various stages of maturation in neutrophil lineage (one myeloblast in the centre, two segments and metamyelocyte). Only one early normoblast is under the myeloblast; beside it to the left is basophil.
Type: bone marrow
Klíčová slova*: myeloblast, metamyelocyte, basophil, segmented granulocyte, normoblast
Chronic myelogenous leukaemia - chronic phase
Hyperplastic bone marrow with increased number of neutrophil segment and their precursors. Maturation pattern is similar to that in perifpheral blood - predominant populations represent mature neutrophils and myelocytes. There are three eosinofiphils in this part of slide (at 9, 3 and 4 o'clock). There isn't presence of significant dysgranulopoiesis . / Hyperplastická kostní dřeň se zvýšeným počtem neutrofilních segmentů a jejich prekurzorů. Rozložení vyzrávání je obdobné jako v periferní krvi - dominující populace jsou představovány zralými neutrofily a myelocyty. V této části nátěru jsou tři eozinofily (na 9., 3. a 4. hodině). Není přítomna zřetelná dysgranulopoéza. Description: Hyperplastic bone marrow with increased number of neutrophil segment and their precursors. Maturation pattern is similar to that in perifpheral blood - predominant populations represent mature neutrophils and myelocytes. There are three eosinofiphils in this part of slide (at 9, 3 and 4 o'clock). There isn't presence of significant dysgranulopoiesis .
Type: bone marrow
Klíčová slova*: myelocyte, eosinophil, segmented granulocyte
Chronic myelogenous leukaemia - chronic phase
Although predominant populations in peripheral blood smears in the disease represent mature segmented neutrophils and myelocytes, all type of immature cells of granulocytic lineage can occur. There are two bands in the picture (2 o'clock and 7 o'clock), and there is one promyelocyte (at 8 o'clock). / I když dominujícími populacemi u této choroby jsou v nátěru periferní krve neutrofilní segmenty a myelocyty, mohou se objevit všechny nezralé buňky granulocytární řady. Na obrázku jsou dvě tyče (na 2. a 7. hodině) a promyelocyt (na 8. hodině). Description: Although predominant populations in peripheral blood smears in the disease represent mature segmented neutrophils and myelocytes, all type of immature cells of granulocytic lineage can occur. There are two bands in the picture (2 o'clock and 7 o'clock), and there is one promyelocyte (at 8 o'clock).
Type: peripheral blood
Klíčová slova*: promyelocyte, myelocyte, band, segmented granulocyte
Chronic myelogenous leukaemia - chronic phase
Peripheral blood smear shows numerous granulocytes with predominate segmented neutrophils and myelocytes (four of them are in the picture). / Nátěry periferní krve ukazují početné granulocyty s predominancí segmentovaných neutrofilů a myelocytů (čtyři na obrázku). Description: Peripheral blood smear shows numerous granulocytes with predominate segmented neutrophils and myelocytes (four of them are in the picture).
Type: peripheral blood
Klíčová slova*: myelocyte, segmented granulocyte
Megaloblastic haematopoiesis- BM
Giant metamyelocytes and bands in neutrophil series are usually present. Detection of these cells is diagnostically important in cases, when megaloblastic features of erythropoiesis are masked by co-existing iron deficiency. Granulopoiesis use to be also hyperplastic in bone marrow, although less so than erythropoiesis. / V neutrofilní řadě jsou obvykle jsou přítomny velké metamyelocyty a tyče. Detekce těchto buněk je diagnosticky důležitá v případech, kdy jsou megaloblastické rysy erytropoézy maskovány současně přítomným nedostatkem železa. Granulopoéza je v kostní dřeni rovněž zmnožena, i když méně nežli erytropoéza. Description: Giant metamyelocytes and bands in neutrophil series are usually present. Detection of these cells is diagnostically important in cases, when megaloblastic features of erythropoiesis are masked by co-existing iron deficiency. Granulopoiesis use to be also hyperplastic in bone marrow, although less so than erythropoiesis.
Type: bone marrow
Klíčová slova*: giant band cell, giant metamyelocyte
Megaloblastic haematopoiesis- BM
There is the giant metamyelocyte at 6 o'clock at a typical change in granulocytic lineage. It is approximately twice times the size of a normal metamyelocyte with abnormal shape of nuclei. There is a hypersegmented neutrophil at right. / Na 6. hodině je gigantický metamyelocyt jako typická změna v granulocytární řadě. Je přibližně dvakrát větší nežli normální metamyelocyt s abnormálním tvarem jádra. Vpravo je hypersegmentovaný neutrofil. Description: There is the giant metamyelocyte at 6 o'clock at a typical change in granulocytic lineage. It is approximately twice times the size of a normal metamyelocyte with abnormal shape of nuclei. There is a hypersegmented neutrophil at right.
Type: bone marrow
Klíčová slova*: metamyelocyte, giant metamyelocyte
CML accelerated phase - PB
Predominance of segmented granulocytes, neutrophil band in the centre, eosinophil myelocyte at the right side bottom, cluster of three blasts in the centre. / Převaha neutrofilních segmentů, neutrofilní tyč uprostřed, eozinofilní myelocyt vpravo dole, shluk tří blastů uprostřed. Description: Predominance of segmented granulocytes, neutrophil band in the centre, eosinophil myelocyte at the right side bottom, cluster of three blasts in the centre.
Type: peripheral blood
Klíčová slova*: myeloblast, eosinophil, band, segmented granulocyte
CML accelerated phase - PB
Leucocytosis, left shift. Two blasts at the right side (at 3. o´clock). basophil on the left. Normoblast in the centre, lymphocyte at the right side up. / Leukocytóza, posun doleva. Dva blasty vpravo ( na 3. hodině), bazofil vlevo. Normoblast uprostřed, lymfocyt vpravo nahoře. Description: Leucocytosis, left shift. Two blasts at the right side (at 3. o´clock). basophil on the left. Normoblast in the centre, lymphocyte at the right side up.
Type: peripheral blood
Klíčová slova*: myeloblast, myelocyte, metamyelocyte, basophil, lymphocyte, normoblast
CML accelerated phase - PB
Marked leucocytosis with granulocytosis. Myelocytes and segmented granulocytes are predominant elements of peripheral blood, marked basophilia. At the picture blasts and promyelocytes are present, six basophiles. / Výrazná leukocytóza s granulocytózou. Myelocyty a neutrofilní segmenty jsou dominujícími elementy v nátěrech periferní krve, výrazná bazofílie. Na obrázku přítomny i blasty a promyelocyty, šest bazofilů. Description: Marked leucocytosis with granulocytosis. Myelocytes and segmented granulocytes are predominant elements of peripheral blood, marked basophilia. At the picture blasts and promyelocytes are present, six basophiles.
Type: peripheral blood
Klíčová slova*: myeloblast, promyelocyte, myelocyte, basophil, segmented granulocyte
CML accelerated phase - BM
Hyperplastic bone marrow with increased number of granulopoetic cells, predominant population represent myelocytes and segmented granulocytes, eosinophiles and blasts are increased, basophilia. Two blasts are present - one is in the centre and one is on the right side up (on the 2 o'clock).Two basophiles are present - one is slightly right up and one at the left side bottom. Eosinophil myelocyte is present on the right upper border of the picture. / Hyperplastická kostní dřeň se zmnožením buněk granulopoezy, dominující populací jsou myelocyty a neutrofilní segmenty, zmnoženy blasty, výrazná bazofílie. Přítomny dva blasty, jeden uprostřed a jeden vpravo nahoře( na 2. hodině) a dva bazofily - jeden mírně vpravo nahoře a jeden vlevo dole. Eosinofilní myelocyt je při pravém horním okraji obrázku. Description: Hyperplastic bone marrow with increased number of granulopoetic cells, predominant population represent myelocytes and segmented granulocytes, eosinophiles and blasts are increased, basophilia. Two blasts are present - one is in the centre and one is on the right side up (on the 2 o'clock).Two basophiles are present - one is slightly right up and one at the left side bottom. Eosinophil myelocyte is present on the right upper border of the picture.
Type: bone marrow
CML accelerated phase - BM
Hyperplastic bone marrow with increased number of granulopoetic cells, predominant population represent myelocytes and segmented granulocytes, blasts are increased, marked basophilia. Two blasts are present - one is in the centre bottom and one is on the right side ( on the 2 o'clock).Three basophiles are present - one in the centre and two at the right side of the picture. / Hyperplastická kostní dřeň se zmnožením buněk granulopoezy, dominující populací jsou myelocyty a neutrofilní segmenty, zmnoženy blasty, je výrazná bazofílie. Přítomny dva blasty, jeden dole uprostřed a jeden vpravo ( na 2. hodině). Jsou přítomny tři bazofily - jeden uprostřed a dva na pravé straně obrázku. Description: Hyperplastic bone marrow with increased number of granulopoetic cells, predominant population represent myelocytes and segmented granulocytes, blasts are increased, marked basophilia. Two blasts are present - one is in the centre bottom and one is on the right side ( on the 2 o'clock).Three basophiles are present - one in the centre and two at the right side of the picture.
Type: bone marrow
Klíčová slova*: myeloblast, myelocyte, metamyelocyte, basophil, segmented granulocyte
CML accelerated phase - BM
Hyperplastic bone marrow with increased number of granulopoetic cells, predominant population represent myelocytes and segmented granulocytes, blasts and eosinophiles are increased. Blast is on the right side bottom , two eosinophil myelocytes are present - one up and one at the bottom in the centre of the picture. / Hyperplastická kostní dřeň se zmnožením buněk granulopoezy, dominující populací jsou myelocyty a neutrofilní segmenty, zmnoženy blasty a eozinofily. Blast vlevo dole, dva eozinofilní myelocyty - jeden nahoře a jeden dole uprostřed obrázku. Description: Hyperplastic bone marrow with increased number of granulopoetic cells, predominant population represent myelocytes and segmented granulocytes, blasts and eosinophiles are increased. Blast is on the right side bottom , two eosinophil myelocytes are present - one up and one at the bottom in the centre of the picture.
Type: bone marrow
Klíčová slova*: myeloblast, myelocyte, metamyelocyte, eosinophil, band, segmented granulocyte
CML accelerated phase - BM
Hyperplastic bone marrow with increased number of granulopoetic cells, predominant population represent myelocytes and segmented granulocytes, blasts and eosinophiles are increased, marked basophilia. Blasts are in the centre and on the right and left side (at 9 and 2 o'clock), eosinophil is in the centre below segmented granulocyte. Four basophiles are present - two at the right side up and two at the bottom part of the picture. / Hyperplastická kostní dřeň se zmnožením buněk granulopoezy, dominující populací jsou myelocyty a neutrofilní segmenty, zmnoženy blasty a eozinofily, výrazná bazofilie. Blasty uprostřed , dále vlevo i vpravo (na 9.a 2.hodině), eozinofil uprostřed pod neutrofilním segmentem,. Bazofilyjsou přítomny 4, dva vpravo nahoře a dva ve spodní části obrázku. Description: Hyperplastic bone marrow with increased number of granulopoetic cells, predominant population represent myelocytes and segmented granulocytes, blasts and eosinophiles are increased, marked basophilia. Blasts are in the centre and on the right and left side (at 9 and 2 o'clock), eosinophil is in the centre below segmented granulocyte. Four basophiles are present - two at the right side up and two at the bottom part of the picture.
Type: bone marrow
Klíčová slova*: myeloblast, myelocyte, eosinophil, basophil, band, segmented granulocyte
AML- peripheral blood
The II-nd type myeloblast. Cell with fine chromatin structure, high nucleus/cytoplasm ratio, three clear nucleoli. Large centrosome is discernible as a lighter juxtanuclear zone with a slight depression of the nucleus; this is sing of more mature cell ( promyelocyte of normal bone marrow). The apparent Auer rod is in the cytoplasm of the cell. . / Myeloblast II. typu. Buňka s jemnou strukturou chromatinu, vysokým nukleo/cytoplazmatickým poměrem, třemi jadérky. Velký centrosom je rozeznatelný jako světlejší juxtanukleární oblast s promáčknutím jádra; to je známka více zralé buňky (promyelocyt v normální kostní dřeni). Zřetelná Auerova tyč je v cytoplazmě buňky. Description: The II-nd type myeloblast. Cell with fine chromatin structure, high nucleus/cytoplasm ratio, three clear nucleoli. Large centrosome is discernible as a lighter juxtanuclear zone with a slight depression of the nucleus; this is sing of more mature cell ( promyelocyte of normal bone marrow). The apparent Auer rod is in the cytoplasm of the cell. .
Type: peripheral blood
Klíčová slova*: myeloblast, Auer rod
Small- cell bronchial carcinoma - BM
Tumour cells' infiltration of the bone marrow - cluster of smaller to middle size cells with high nucleus - cytoplasm ratio, there is fine chromatin in the nucleus with one to more nucleoli. There is one hypergranular neutrophile myelocyte at left side, segmented neuthrophil with pseudo-pelgeroid appearance at the top and late erythroblast at the upper left, there are same naked nucleoli at the smear. / Infiltrace nádorovými buňkami - trs menších a středně velkých buněk s vysokým poměrem jádra a cytoplazmy, v jádře jemný chromatin s jedním až několika jadérky. Vlevo je jeden hypergranulovaný neutrofilní myelocyt, nahoře neutrofilní segment pseudo-pelgeroidního vzhledu a vpravo nahoře pozdní erytroblast, v nátěru je také několik holých jader. Description: Tumour cells' infiltration of the bone marrow - cluster of smaller to middle size cells with high nucleus - cytoplasm ratio, there is fine chromatin in the nucleus with one to more nucleoli. There is one hypergranular neutrophile myelocyte at left side, segmented neuthrophil with pseudo-pelgeroid appearance at the top and late erythroblast at the upper left, there are same naked nucleoli at the smear.
Type: bone marrow
Klíčová slova*: myelocyte, orthochromatophilic normoblast, hypergranulation, naked nucleus, tumour cell
Small- cell bronchial carcinoma - BM
The first example of the bone marrow infiltration in this case - the cluster of the middle size cells with narrow rim of basophilic cytoplasm; there is fine chromatin and some nucleoli in the nucleus. There is eosinophil metamyelocyte at the upper left, neutrophil metamyelocyte at the upper right and there are two late erythroblasts at the upper part of the picture. Naked nucleoli are the typical content of the smear. / První příklad infiltrace nádorovými buňkami u tohoto případu - trs středně velkých buněk s úzkým lemem bazofilní cytoplamy; v jádře je jemný chromatin a jadérka. Vlevo nahoře eosinofilní metamyelocyt, vpravo nahoře neutrofilní metamyelocyt, v horní části obrázku dva pozdní erytroblasty. Holá jádra jsou typickou součástí nátěru. Description: The first example of the bone marrow infiltration in this case - the cluster of the middle size cells with narrow rim of basophilic cytoplasm; there is fine chromatin and some nucleoli in the nucleus. There is eosinophil metamyelocyte at the upper left, neutrophil metamyelocyte at the upper right and there are two late erythroblasts at the upper part of the picture. Naked nucleoli are the typical content of the smear.
Type: bone marrow
Klíčová slova*: metamyelocyte, orthochromatophilic normoblast, naked nucleus, tumour cell
APL- bone marrow 4
Smear show typical pathological cells of acute promyelocytic leukamia - hypergranulated abnormal promyelocyte and "faggot cells". Rest of cells are two normoblasts and damaged cells. / Nález ukazuje typické patologické elementy akutní promyelocytární leukémie- hypergranulované abnormální promyelocyty a tzv."faggot cells". Zbytek buněk tvoří dva normoblasty a rozbité buňky. Description: Smear show typical pathological cells of acute promyelocytic leukamia - hypergranulated abnormal promyelocyte and "faggot cells". Rest of cells are two normoblasts and damaged cells.
Type: bone marrow
Klíčová slova*: faggot cell
AML M2- bone marrow 1
In the center two blasts and promyelocyte, one blast with single Auer rod. / V centru dva blasty a promyelocyty , jeden blast se solitární Auerovou tyčí. Description: In the center two blasts and promyelocyte, one blast with single Auer rod.
Type: bone marrow
Klíčová slova*: myeloblast, promyelocyte, Auer rod
AMML Eo bone marrow
Hyper-cellular bone marrow with mixture of tumour cells of granulocytic and monocytic lineages. Two characteristic eosinophil myelocytes, that in at right has vacuolized cytoplasm. Eosinophil the mostly at right is promyelocyt with numerous purple pro-granules. / Hypercelulární kostní dřeň se směsí nádorových buněk granulocytární a monocytární linie. Dva charakteristické eozinofilní myelocyty, ten vpravo má vakuolizovanou cytoplazmu. Eozinofil nejvíce vpravo je promyelocyt s početnými purpurovými progranuly. Description: Hyper-cellular bone marrow with mixture of tumour cells of granulocytic and monocytic lineages. Two characteristic eosinophil myelocytes, that in at right has vacuolized cytoplasm. Eosinophil the mostly at right is promyelocyt with numerous purple pro-granules.
Type: bone marrow
Klíčová slova*: myeloblast, promyelocyte, eosinophil, promonocyte, monocyte
AMML Eo bone marrow
Blasts and promonocytes, eosinophils with atypical "basophil like" granulation. One promyelocyte at 5 o' clock. Eosinophil component reaches almost 14% of nucleated bone marrow cells. / Blasty a promonocyty, eozinofily s atypickou granulací napodobující "basofilní". Jeden promyelocyt na 5. hodině. Eozinofilní komponenta dosahuje téměř 14% z jaderných buněk kostní dřeně. Description: Blasts and promonocytes, eosinophils with atypical "basophil like" granulation. One promyelocyte at 5 o' clock. Eosinophil component reaches almost 14% of nucleated bone marrow cells.
Type: bone marrow
Klíčová slova*: eosinophil, promonocyte
AMML Eo bone marrow
Several blasts with heterogeneous morphology, one monocyte and two eosinophils. This one at the left is really immature (promyelocyte), has a few large granules purple-violet in colour reminding basophilic granulation mixing with eosinophlic granules. Naked nuclei and damaged cells. / Několik blastů různorodé morfologie, jeden monocyt a dva eozinofily. Ten vlevo je skutečně nezralý (promyelocyt), má několik velkých granulí purpurově-fialové barvy připomínající basofilní granulaci smíchaných s granulemi eozinofilními. Holá jádra a poškozené buňky. Description: Several blasts with heterogeneous morphology, one monocyte and two eosinophils. This one at the left is really immature (promyelocyte), has a few large granules purple-violet in colour reminding basophilic granulation mixing with eosinophlic granules. Naked nuclei and damaged cells.
Type: bone marrow
Klíčová slova*: myeloblast, eosinophil, monocyte
MDS RAEB II
In the upper part of the picture note a myeloblast wiht Auer rods, and nucleoli. Below this cell there is a plasmatic cell and two promyelocytes. On the right there is a group of two megaloblasts and two normoblast. / V horní části obrázku leží myeloblast s několika Auerovými tyčemi, v jádře zřetelná jadérka, pod ním plasmatická buňka a dva promyelocyty. Vpravo skupina erytroblastů se 2 normoblasty a 2 megaloblasty. Description: In the upper part of the picture note a myeloblast wiht Auer rods, and nucleoli. Below this cell there is a plasmatic cell and two promyelocytes. On the right there is a group of two megaloblasts and two normoblast.
Type: bone marrow
Klíčová slova*: myeloblast, normoblast, plasma cell, megaloblast, Auer rod
MDS RAEB II
In the middle of this picture you can see a blast with clear Auer rods (visible clear nucleoli). On the left there is a large metamyelocyte. In cells of myeloid lineage a dense hypergranulation is visible. / Uprostřed obrázku blast s Auerovými tyčemi (zřetelná jadérka). Na levo velký metamyelocyt . Hrubá hypergranulace v buňkách myelořady. Description: In the middle of this picture you can see a blast with clear Auer rods (visible clear nucleoli). On the left there is a large metamyelocyte. In cells of myeloid lineage a dense hypergranulation is visible.
Type: bone marrow
Klíčová slova*: Auer rod, hypergranulation, giant metamyelocyte
MDS RAEB II
Three blasts. In the cytoplasm of the blast in the middle, there are clearly seen Auer's rods. Below the myelocyte there is a megaloblast. Hypergranulation in cells of myeloid lineage. / Na obrázku 3 blasty, v cyoplasmě prostředního zřetelné Auer.tyče. Pod myelocytem megaloblast. Hypergranulace v buňkách myelořady. Description: Three blasts. In the cytoplasm of the blast in the middle, there are clearly seen Auer's rods. Below the myelocyte there is a megaloblast. Hypergranulation in cells of myeloid lineage.
Type: bone marrow
Klíčová slova*: myelocyte, megaloblast, Auer rod, hypergranulation
MDS RAEB II
Large metamyelocyte and three blasts with visible nucleoli. / Na obrázku je obrovský metamyelocyt a tři blasty s viditelnými jadérky. Description: Large metamyelocyte and three blasts with visible nucleoli.
Type: bone marrow
Klíčová slova*: metamyelocyte, giant metamyelocyte
MDS RAEB II
In the left part on the picture there is immature megakaryocyte with single nucleus and withaut mature granulomer. In the right part of the picture we can see the beginning of the apoptosis of the neutrophil. In the myelocytes and metamyelocytes you can see hypergranularity. / V levé části obrázku nezralý megakaryocyt s nefragmentovaným jádrem a nevytvořeným granulomerem. V pravé části obrázku počínající apoptóza neutrofilu. V buňkách myelořady hypergranulace. Description: In the left part on the picture there is immature megakaryocyte with single nucleus and withaut mature granulomer. In the right part of the picture we can see the beginning of the apoptosis of the neutrophil. In the myelocytes and metamyelocytes you can see hypergranularity.
Type: bone marrow
Klíčová slova*: megakaryocyte, hypogranulation
APL- bone marrow 3
At centre of the picture are two "faggot cells" on the right, two abnormal hypergranular promyelocytes on the left- one with cleaved or bilobated nucleus. Below are two hypergranular myelocytes with large reddish inclusions- upper myelocyt with cleaved nucleus, both of them are impaired. / Uprostřed snímku jsou dvě "faggot cells" vpravo, dva abnormální hypergranulované promyelocyty vlevo- jeden s rozštěpeným nebo dvoulaločnatým jádrem. Pod nimi dva hypergranulované myelocyty s objemnými inkluzemi- horní buňka s rozštěpeným jádrem, obě jsou poškozené. Description: At centre of the picture are two "faggot cells" on the right, two abnormal hypergranular promyelocytes on the left- one with cleaved or bilobated nucleus. Below are two hypergranular myelocytes with large reddish inclusions- upper myelocyt with cleaved nucleus, both of them are impaired.
Type: bone marrow
Klíčová slova*: myelocyte, faggot cell, hypergranulation
APL- bone marrow 2
Smear shows "faggot cells" with numerous Auer rods, myeloblasts and above to the left hypergranulated myelocyte. / Nátěr ukazuje "faggot cells" s početnými Auerovými tyčemi, vlevo nahoře hypergranulovaný myelocyt. Description: Smear shows "faggot cells" with numerous Auer rods, myeloblasts and above to the left hypergranulated myelocyte.
Type: bone marrow
Klíčová slova*: myelocyte, Auer rod, faggot cell, hypergranulation
APL- peripheral blood 6
Pseudo Chediak-Higashi granule in hypergranulated promyelocyte. Two mature lymphocytes with short polar villi, but along the spread (artificial). / Pseudo Chediak- Higashiho granula u hypergranulovaného promyelocytu. Dva zralé lymfocyty s krátkými "vlásky" na pólech buňky, ale ve směru nátěru (arteficiálně). Description: Pseudo Chediak-Higashi granule in hypergranulated promyelocyte. Two mature lymphocytes with short polar villi, but along the spread (artificial).
Type: peripheral blood
Klíčová slova*: promyelocyte, lymphocyte, hypergranulation
APL- peripheral blood 5
At top is abnormal promyelocyte with large numerous granules, in comparison below is mature basophil. / Nahoře abnormální promyelocyt s objemnou početnou granulací, ke srovnání dole zralý bazofil. Description: At top is abnormal promyelocyte with large numerous granules, in comparison below is mature basophil.
Type: peripheral blood
Klíčová slova*: promyelocyte, basophil
APL- peripheral blood 4
Hypergranular promyelocyte with large reddish inclusion (pseudo Chediak-Higashi granule). / Hypergranulovaný promyelocyt s objemnou inkluzí (pseudo Chediak- Higashiho granula). Description: Hypergranular promyelocyte with large reddish inclusion (pseudo Chediak-Higashi granule).
Type: peripheral blood
Klíčová slova*: promyelocyte, hypergranulation
APL- peripheral blood 1
At centre of the picture abnormal promyelocyte with cleaved nucleus. / Uprostřed snímku abnormální promyelocyt s rozštěpeným jádrem. Description: At centre of the picture abnormal promyelocyte with cleaved nucleus.
Type: peripheral blood
Klíčová slova*: promyelocyte
CML - bone marrow
Hyperplastic bone marrow with an increase of the granulocytic line and with two peaks in the percentages of myelocytes and segmented neutrophils. / Hyperplastická kostní dřeň se zvýšením granulocytární řady s dvěma vrcholy v procentech myelocytů a neutroiflních segmentů. Description: Hyperplastic bone marrow with an increase of the granulocytic line and with two peaks in the percentages of myelocytes and segmented neutrophils.
Type: bone marrow
Klíčová slova*: myelocyte, segmented granulocyte
CML - peripheral blood
Myelocytes and neutrophil segments are predominant cells in peripheral blood smears. / Myelocyty a neutrofilní segmenty jsou dominujícími elementy v nátěrech periferní krve. Description: Myelocytes and neutrophil segments are predominant cells in peripheral blood smears.
Type: peripheral blood
Klíčová slova*: myelocyte, segmented granulocyte
CML - bone marrow
Granulocytic hyperplasia - some eosinophils and basophils, predominant cells are mature neutrophils and myelocytes. Smear do not shows any marked dysplastic changes but one hypo-granular pseudo-pelgeroid segmented neutrophil (underneath centre of the picture at the 5 o'clock). / Granulocytární hyperplázie - několik eozinoiflů a bazofilů, dominujícími buňkami jsou zralé neutrofily a myelocyty. Nátěr neukazuje žádné zřetelné dysplastické změny s výjimkou jednoho hypogranulárního pseudo-pelgeroidního neutrofilního segmentu (pod centrem obrázku na 5. hodině). Description: Granulocytic hyperplasia - some eosinophils and basophils, predominant cells are mature neutrophils and myelocytes. Smear do not shows any marked dysplastic changes but one hypo-granular pseudo-pelgeroid segmented neutrophil (underneath centre of the picture at the 5 o'clock).
Type: bone marrow
Klíčová slova*: myelocyte, eosinophil, basophil, segmented granulocyte, pseudo-Pelger anomaly, hypogranulation
CML - peripheral blood
Smear shows numerous myelocytes and segmented neutrophils. One basophil at the 8 o'clock. / Nátěr ukazuje četné myelocyty a neutrofilní segmenty. Jeden basofil na 8. hodině. Description: Smear shows numerous myelocytes and segmented neutrophils. One basophil at the 8 o'clock.
Type: peripheral blood
Klíčová slova*: myelocyte, basophil, segmented granulocyte
CML - peripheral blood
In the middle of the picture are myelocytes, segmented neutrophils and two rather immature eosinophils. Mature basophil is on the left. / Uprostřed obrázku jsou myelocyty, neutrofilní segmenty a dva spíše nezralé eozinofily. Zralý basofil je nalevo. Description: In the middle of the picture are myelocytes, segmented neutrophils and two rather immature eosinophils. Mature basophil is on the left.
Type: peripheral blood
Klíčová slova*: myelocyte, eosinophil, basophil, segmented granulocyte
AML M4 EO, BM
Blast cells in M4 Eo. Note 3 immature eosinophils, 2 of them with dark blue granules, typical for eosinophils of M4 Eo. / Blastické bb. u M4 Eo - mezi nimi 3 nezralé eosinofily. Ve 2 z nich i tmavomodře se barvící granula, typická pro eosinofily u M4 Eo. Description: Blast cells in M4 Eo. Note 3 immature eosinophils, 2 of them with dark blue granules, typical for eosinophils of M4 Eo.
Type: bone marrow
Klíčová slova*: myelocyte, eosinophil, monoblast
AML M4 EO, BM
Myeloid and monocytic blast cells, on the right side 3 immature eosinophiles. Note large basophilic granules in adition to eosinophilic ones in cells seen on the right.. / Na obrázku myeloidní a monocytoidní blastické bb. V pravé polovině 3 mladé Eo, vpravo nahoře a vpravo dole bb., které mají kromě eosinofilních i velká basofilní granula. Description: Myeloid and monocytic blast cells, on the right side 3 immature eosinophiles. Note large basophilic granules in adition to eosinophilic ones in cells seen on the right..
Type: bone marrow
Klíčová slova*: myeloblast, metamyelocyte, eosinophil, monoblast
AML M4 EO, BM
Upwards on the left and in the centre note immature eosiniphils showing double granulation i.e. eosinophilic and large basophilic granules, typical for M4 Eo. Downwards a monocyte is seen. / Vlevo nahoře a uprostřed obrázku nezralý Eo s dvojí granulací, t.j. kromě eosinofilních granul i velká tmavá basofilní granula, typická pro Eo u M4 Eo. V horní části monocyt. Description: Upwards on the left and in the centre note immature eosiniphils showing double granulation i.e. eosinophilic and large basophilic granules, typical for M4 Eo. Downwards a monocyte is seen.
Type: bone marrow
Klíčová slova*: myelocyte, eosinophil