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147 cs: Chronická myeloidní leukémie - akcelerace onemocnění
en: Chronic myelogenous leukaemia - accelerated phase 		7 Irena Trnavská, J. Kissová 3.5.2008, 21:08 9.9.2009, 23:06 9.9.2009, 23:06 J. Kissová
131 cs: AML M5a
en: AML M5a 		8 S. Valníček 21.1.2008, 12:49 1.7.2010, 11:26 1.7.2010, 11:26 Jan Blatný
31 cs: Rhabdomyosarkom
en: Rhabdomyosarcoma 		9 S. Valníček 14.11.2006, 11:43 3.12.2007, 19:01 3.12.2007, 19:01 Jan Blatný
29 cs: ALL L1, ALL L2 (BFM klasifikace-morfologická)
en: ALL L1, ALL L2 (BFM morfologic classification) 		4 S. Valníček 10.11.2006, 10:47 3.12.2007, 19:04 3.12.2007, 19:04 Jan Blatný
25 cs: AML M4 Eo
en: AML M4 Eo 		8 S. Valníček 27.10.2006, 13:47 4.12.2007, 10:41 4.12.2007, 10:41 Jan Blatný
12 cs: ALL L3
en: ALL L3 		1 S. Valníček 23.10.2006, 9:18 3.12.2007, 19:22 3.12.2007, 19:22 Jan Blatný


Nalezené obrázky* (n=55)

AML without maturation - PB
Myeloblasts in peripheral blood smear represent dominant population. These are large cell, they have high nucleocytoplasmic ratio. Their nucleus has diffuse fine chromatin pattern and one or more nucleoli. The cytoplasm is moderately basophilic in this case and do not contain any granulation. / Myeloblasty v nátěru perifetní krve představují dominující populaci. Jsou to velké buňky, mají vysoký nukleocytoplazmatický poměr. Jejich jádro má difusní jemný vzhled chromatinu a jedno či více jadérek. Cytoplazma je v tomto případě středně basofilní a neobsahuje žádnou granulaci. Description: Myeloblasts in peripheral blood smear represent dominant population. These are large cell, they have high nucleocytoplasmic ratio. Their nucleus has diffuse fine chromatin pattern and one or more nucleoli. The cytoplasm is moderately basophilic in this case and do not contain any granulation.
Type: peripheral blood
Klíčová slova*: myeloblast
AML without maturation- PB
Almost only myeloblasts are detected in peripheral blood. They are various size with moderate to almost strong basophilic cytoplasm without any granulation. / Téměř výhradně myeloblasty jsou zjišťovány v periferní krvi. Jsou různé velikosti se středně až téměř silně basofilní cytoplazmou bez jakékoli granulace. Description: Almost only myeloblasts are detected in peripheral blood. They are various size with moderate to almost strong basophilic cytoplasm without any granulation.
Type: peripheral blood
Klíčová slova*: myeloblast
AML without maturation- BM
There are numerous myeloblasts with fine nuclear chromatin, one to four nucleoli, moderately basophilic cytoplasm without granulation. No other more mature cells of granulocytic lineage are find. One cell of erythroid lineage is at 7 o'clock. / Tady jsou četné myeloblasty s jemným jaderným chromatinem, jedním až čtyřmi jadérky, středně bazofilní cytoplazmou bez granulace. Žádné další více zralé buňky granulocytární řady nejsou zjišťovány. Jedna buňka erytroidní linie je na 7. hodině. Description: There are numerous myeloblasts with fine nuclear chromatin, one to four nucleoli, moderately basophilic cytoplasm without granulation. No other more mature cells of granulocytic lineage are find. One cell of erythroid lineage is at 7 o'clock.
Type: bone marrow
Klíčová slova*: myeloblast, polychromatophilic normoblast
AML with multilineage dysplasia - PB
There are two myeloblasts here - rather large cells with round or oval nuclei, fine chromatin pattern, two to three nucleoli, moderately basophilic cytoplasm without granulation. One lymphocyte lays beside myeloblast at the left side of the picture. / Zde jsou dva myeloblasty - spíše velké buňky s kulatými až oválnými jádry, jemným vzorkem chromatinu, dvěma až třemi jadérky, středně basofilní cytoplazmou bez granulace. Jeden lymfocyt leží vedle myeloblastu na levé straně obrázku. Description: There are two myeloblasts here - rather large cells with round or oval nuclei, fine chromatin pattern, two to three nucleoli, moderately basophilic cytoplasm without granulation. One lymphocyte lays beside myeloblast at the left side of the picture.
Type: peripheral blood
Klíčová slova*: myeloblast, lymphocyte
AML with multilineage dysplasia - BM
Three myeloblast and six erythroid cells (and one naked nucleus) are in the picture. Two immature erythroid cells with abundant basophilic cytoplasm are megalobasts. At the lower left is one more cell probably of granulocytic lineage; it has a few cytoplasmic a one nuclear inclusions of not clear origin - some of them can be digestive ones after haemophagocytosis (one at 6 o'clock in the cell). / Na obrázku jsou tři myeloblasty a šest buněk erytropoezy (a jedno holé jádro). Dvě nezralé erytroidní buňky s bohatou bazofilní cytoplazmou jsou megaloblasty. Nalevo dole je jedna buňka pravděpodobně granulocytární řady; má pár cytoplazmatických a jednu jadernou inkluzi nejasného původu - některé z nich mohou být ztrávené po hemofagocytóze (jedna na 5. hodině v buňce). Description: Three myeloblast and six erythroid cells (and one naked nucleus) are in the picture. Two immature erythroid cells with abundant basophilic cytoplasm are megalobasts. At the lower left is one more cell probably of granulocytic lineage; it has a few cytoplasmic a one nuclear inclusions of not clear origin - some of them can be digestive ones after haemophagocytosis (one at 6 o'clock in the cell).
Type: bone marrow
Klíčová slova*: myeloblast, megaloblast, haemophagocytosis
AML with multilineage dysplasia - BM
There are three myeloblasts in the picture, one of them underneath the centre with cleft nucleus. Three immature cells of erythroid lineage (proerythroblast and two more or less mature early normoblasts) belong to cells localized around the picture's centre. At 5 o'clock lays one dysplastic cell of perhaps granulocytic or may be monocytic lineage; it has band-like but really immature nucleus with fine chromatin and clear nucleoli and immature cytoplasm without granulation. Another almost bizarre cell is in the centre, it the most probably belongs in granulocytic series, it has moderately mature nucleus, basophilic cytoplasm almost without granulation but with one digested late normoblast. / Na obrázku jsou tři myeloblasty, jeden z nich pod centrem se štěpeným jádrem. Tři nezralé buňky erytroidní linie (proerytroblast a dva méně či více zralé časné normoblasty patří k buňkám umístěným okolo středu obrázku. Na 5. hodině leží dysplastická buňka granulocytární nebo možná monocytární řady; má tyčkovité ale opravdu nezralé jádro s jemným chromatinem a jasnými jadérky a nezralou cytoplazmu bez granulace. Jiná téměř bizarní buňka je ve středu, nejpravděpodobněji patří ke granulocytární řadě, má středně zralé jádro, basofilní cytoplazmu téměř bez granulace ale s jedním pohlceným pozdním normoblastem. Description: There are three myeloblasts in the picture, one of them underneath the centre with cleft nucleus. Three immature cells of erythroid lineage (proerythroblast and two more or less mature early normoblasts) belong to cells localized around the picture's centre. At 5 o'clock lays one dysplastic cell of perhaps granulocytic or may be monocytic lineage; it has band-like but really immature nucleus with fine chromatin and clear nucleoli and immature cytoplasm without granulation. Another almost bizarre cell is in the centre, it the most probably belongs in granulocytic series, it has moderately mature nucleus, basophilic cytoplasm almost without granulation but with one digested late normoblast.
Type: bone marrow
Klíčová slova*: myeloblast, proerythroblast, basophilic normoblast, haemophagocytosis
Anaplastic large cell lymphoma - ALK negative
Two closely pressed malignant lymphoma cells with ex-centric nucleus, reticular chromatin pattern, few nucleoli and abundant pale basophilic finely vacuolized cytoplasm. / Dvě těsně přitištěné maligní lymfomové buňky s excentrickým jádrem, síťovitým vzorkem jaderného chromatinu, několika jadérky a bohatou světle bazofilní jemně vakuolizovanou cytoplazmou. Description: Two closely pressed malignant lymphoma cells with ex-centric nucleus, reticular chromatin pattern, few nucleoli and abundant pale basophilic finely vacuolized cytoplasm.
Type: bone marrow
Klíčová slova*: lymphocyte atypical
Medulloblastom
BM metastasis.Large cluster of malignant cells with polymorphic cellular and nuclear shape and size.Nuclei rather eccentrically located, irregular or lobed, some with large nuclei.Marked vacuoles of basophilic cytoplasm and also of some of the nuclei.Left upper part of the picture shows a segmented neutrophile and a hypogranular myelocyte. / Metastáza v KD.Velký shluk maligních buněk, zřetelná polymorfie tvaru a velikosti buněk i jader,zejména ve srovnání s neuroblastomem. Jádra spíše excentricky uložena,nepravidel- ná,až laločnatá,oj.s velkými jadérky.Cytoplasma basofilní, výrazně vakuolizovaná,částečně i vakuolizace jader.Vlevo nahoře segmentovaný neutrofil a hypogranulární myeolocyt. Description: BM metastasis.Large cluster of malignant cells with polymorphic cellular and nuclear shape and size.Nuclei rather eccentrically located, irregular or lobed, some with large nuclei.Marked vacuoles of basophilic cytoplasm and also of some of the nuclei.Left upper part of the picture shows a segmented neutrophile and a hypogranular myelocyte.
Type: bone marrow
Klíčová slova*: tumour cell
Medulloblastom
A cluster of medulloblastoma cells of unequal size with nuclear chromatin of a coarse structure In some of the cells there are nucleoli, irregular cell membrane , with incisions, occasionally with incipient lobulisation.Cytoplasm basophilic, locally with slightly acidophilic areas. Cytoplasm is markedly vacuolised, in some of the cells there are vacuoles also in the nuclei, / trs meduloblastomových buněk nestejné verlikosti, chromatin jaderný je hruběji strukturován, v některých buňkách patrná jadérka, membrána jaderná nepravidelná, se zářezy, někdy s náznakem lobulizace. Cytoplasma basofilní, místy s lehce acidofilními okrsky, cytoplasma má nápadnou vakuolizací, která je v některých buňkách i v jádře. Description: A cluster of medulloblastoma cells of unequal size with nuclear chromatin of a coarse structure In some of the cells there are nucleoli, irregular cell membrane , with incisions, occasionally with incipient lobulisation.Cytoplasm basophilic, locally with slightly acidophilic areas. Cytoplasm is markedly vacuolised, in some of the cells there are vacuoles also in the nuclei,
Type: bone marrow
Klíčová slova*: tumour cell
Anaplastic large cell lymphoma - ALK negative
Three tumour cells in ALCL. They have pale basophilic cytoplasm, fine reticular nuclear chromatin and few dark blue nucleoli. There are two nuclear fragments in cytoplasm one of them (upper left). At the upper right are two immature neutrophils (upper promyelocyte, lower myelocyte). / Tři nádorové buňky u ALCL. Mají světle bazofilní cytoplazmu, jemný síťovitý jaderný chromatin a několik tmavě modrých jadérek. V cytoplazmě jedné z nich jsou dva jaderné fragmenty (nahoře vlevo). Nahoře vpravo jsou dva nezralé neutrofily (horní promyelocyt, dolní myelocyt). Description: Three tumour cells in ALCL. They have pale basophilic cytoplasm, fine reticular nuclear chromatin and few dark blue nucleoli. There are two nuclear fragments in cytoplasm one of them (upper left). At the upper right are two immature neutrophils (upper promyelocyte, lower myelocyte).
Type: bone marrow
Klíčová slova*: promyelocyte, myelocyte, tumour cell
Anaplastic large cell lymphoma - ALK negative
Bi-nuclear tumour cell in ALCL T- lymphoma. Each nucleus contains few various size dark blue nucleoli. Nuclear chromatin is rather fine of reticular appearance. Cell has abundant moderately basophilic cytoplasm with cytoplasmic protrusions (at right). / Dvojjaderná nádorová buňka u ALCL T- lymfomu. Každé jádro obsahuje několik různě velkých tmavě modrých jadérek. Jaderný chromatin je spíše jemný síťovitého vzhledu. Buňka má objemnou středně bazofilní cytoplazmu s cytoplazmatickými výběžky (napravo). Description: Bi-nuclear tumour cell in ALCL T- lymphoma. Each nucleus contains few various size dark blue nucleoli. Nuclear chromatin is rather fine of reticular appearance. Cell has abundant moderately basophilic cytoplasm with cytoplasmic protrusions (at right).
Type: bone marrow
Klíčová slova*: tumour cell
Anaplastic large cell lymphoma - ALK negative
One tumour cell in ALCL (middle right) - large cell with fine nuclear chromatin, prominent nucleolus, abundant cytoplasm which basophilia passes to eosinophilia. There are also three neutrophil myelocytes (upper one is destroyed), one lymphocyte (at 3 o'clock). The last cell in the picture is macrophage (between two myelocytes). These cells are typical component of this lymphohistiocytic variant of the lymphoma . / Jedna nádorová buňka u ALCL (ve středu vpravo) - velká buňka s jemným jaderným chromatinem, prominujícím jadérkem, bohatou cytoplazmou jejíž basofilie přechází do eozinofilie. Také jsou zde tři neutrofilní myelocyty (horní je poškozený), jeden lymfocyt (na 3. hodině). Poslední buňkou na obrázku je makrofág (mezi dvěma myelocyty). Tyto buňky jsou typickou součástí této lymfohistiocytární varianty lymfomu. Description: One tumour cell in ALCL (middle right) - large cell with fine nuclear chromatin, prominent nucleolus, abundant cytoplasm which basophilia passes to eosinophilia. There are also three neutrophil myelocytes (upper one is destroyed), one lymphocyte (at 3 o'clock). The last cell in the picture is macrophage (between two myelocytes). These cells are typical component of this lymphohistiocytic variant of the lymphoma .
Type: bone marrow
Klíčová slova*: myelocyte, macrophage, tumour cell
Anaplastic large cell lymphoma - ALK negative
Large cell with kidney-shaped nucleus with eosinophilic region in cytoplasm at lower right quadrant of the cell, while another parts of cytoplasm is basophilic. The cytoplasm is abundant. There are some blue nucleoli in the nucleus. The cell size one can estimate to 40 micrometers and more. / Velká buňka s ledvinovitým tvarem jádra s eozinofilní oblastí v cytoplazmě v dolním pravém kvadrantu buňky. Cytoplazma je bohatá. Několik modrých jadérek je v jádře. Velikost buňky může být odhadována na 40 mikrometrů a více. Description: Large cell with kidney-shaped nucleus with eosinophilic region in cytoplasm at lower right quadrant of the cell, while another parts of cytoplasm is basophilic. The cytoplasm is abundant. There are some blue nucleoli in the nucleus. The cell size one can estimate to 40 micrometers and more.
Type: bone marrow
Klíčová slova*: lymphocyte atypical
Anaplastic large cell lymphoma - ALK negative
Two lymphoma cells are in the picture. One of them is large with almost round nucleus with fine chromatin and prominent nucleoli, abundant basophilic cytoplasm converts to more basophilic at the right perinuclear area. Another lymphoma cell is smaller (at 8 o'clock) with ex-centric nucleus. It contains fine chromatin and 2 to 3 small nucleoli. Other cells of the picture belong to neutrophil lineage including one mitosis (at the right from the centre). There is one monocyte above at large lymphoma cell. / Na obrázku jsou dvě lymfomové buňky. Jedna z nich je velká s téměř kulatým jádrem, s jemným jaderným chromatinem a prominujícími jadérky, bohatá bazofilní cytoplazma se mění ve více eozinofilní v pravé perinukleární oblasti. Jiná lymfomová buňka (na 8. hodině) je menší s excentrickým jádrem. Obsahuje jemný jaderný chromatin a 2-3 malá jadérka. Další buňky na obrázku patří neutrofilní řadě včetně jedné mitózy (napravo od středu). Jeden monocyt je nad velkou lymfomovou buňkou. Description: Two lymphoma cells are in the picture. One of them is large with almost round nucleus with fine chromatin and prominent nucleoli, abundant basophilic cytoplasm converts to more basophilic at the right perinuclear area. Another lymphoma cell is smaller (at 8 o'clock) with ex-centric nucleus. It contains fine chromatin and 2 to 3 small nucleoli. Other cells of the picture belong to neutrophil lineage including one mitosis (at the right from the centre). There is one monocyte above at large lymphoma cell.
Type: bone marrow
Klíčová slova*: monocyte, lymphocyte atypical
Splenic marginal zone B-cell lymphoma
The most of lymphocytes in the picture belong to lymphoma cells. But that one at 5 o'clock is large granular lymphocyte (LGL) - it means NK cell or mature T lymphocyte. Also lymphocyte at 4 o'clock does not seems to be lymphoma cell. It can be reactive lymphocyte according to pale cytoplasm with more basophilic rim. / Většina lymfocytů na obrázku patří k lymfomovým buňkám. Ale ta na 5. hodině je velký granulovaný lymfocyt (LGL) - to znamená NK buňka či zralý T lymfocyt. Také lymfocyt na 4. hodině se nezdá být buňkou lymfomovou. Může jít o reaktivní lymfocyt podle světlé cytoplazmy s více bazofilním okrajem. Description: The most of lymphocytes in the picture belong to lymphoma cells. But that one at 5 o'clock is large granular lymphocyte (LGL) - it means NK cell or mature T lymphocyte. Also lymphocyte at 4 o'clock does not seems to be lymphoma cell. It can be reactive lymphocyte according to pale cytoplasm with more basophilic rim.
Type: bone marrow
Klíčová slova*: lymphocyte reactive, large granular lymphocyte, lymphocyte atypical
Splenic marginal zone B- cell lymphoma
Middle size cells with rather abundant cytoplasm with villi. When one compare there cells with tumour cells of hairy cell leukaemia, they have more basophilic cytoplasm and cytoplasmic projections are more thick and less numerous. / Středně velké buňky se spíše bohatou cytoplazmou s vlásky. Při srovnání těchto buněk s nádorovými buňkami vlasatobuněčné leukémie mají tyto více bazofilní cytoplazmu a cytoplazmatické projekce jsou silnější a méně početné. Description: Middle size cells with rather abundant cytoplasm with villi. When one compare there cells with tumour cells of hairy cell leukaemia, they have more basophilic cytoplasm and cytoplasmic projections are more thick and less numerous.
Type: peripheral blood
Klíčová slova*: lymphocyte atypical
Splenic marginal zone B- cell lymphoma
"Villous lymphocyte" in detail. Rather abundant basophilic cytoplasm with few projections at two opposite sides of the cell. One poorly seen nucleolus is at the lower part of nucleus. Cytoplasm contains some vacuoles and one cytoplasmic inclusion. / "Vilózní lymfocyt" v detailu. Spíše bohatší bazofilní cytoplazma s několika projekcemi na dvou protilehlých stranách buňky. Jedno špatně viditelné jadérko v dolní části jádra. Cytoplazma obsahuje několik vakuol a jednu cytoplazmatickou inkluzi. Description: "Villous lymphocyte" in detail. Rather abundant basophilic cytoplasm with few projections at two opposite sides of the cell. One poorly seen nucleolus is at the lower part of nucleus. Cytoplasm contains some vacuoles and one cytoplasmic inclusion.
Type: peripheral blood
Klíčová slova*: lymphocyte atypical
Splenic marginal zone B-cell lymphoma
In this thinner part of the smear lymphoma cells are better seen in details. Cells have moderately condensed chromatin, nucleoli are rather inconspicuous in this case. Cytoplasm is basophilic with clear projections (two cells at the lower left). / V této tenčí části nátěru jsou lymfomové buňky lépe viditelné v detailech. Buňky mají středně kondenzovaný chromatin, jadérka jsou v tomto případě spíše nezřetelná. Cytoplazma je bazofilní s jasnými projekcemi (dvě buňky vlevo dole). Description: In this thinner part of the smear lymphoma cells are better seen in details. Cells have moderately condensed chromatin, nucleoli are rather inconspicuous in this case. Cytoplasm is basophilic with clear projections (two cells at the lower left).
Type: peripheral blood
Klíčová slova*: lymphocyte atypical
Splenic marginal zone B- cell lymphoma
Another example of "villous lymphocytes" in peripheral blood smear (without EDTA). Cytoplasm of the lymphoma cells is quite basophilic. One segmented eosinophil at the middle left. / Jiný příklad "vilózních lymfocytů" v nátěru periferní krve (bez EDTA). Cytoplazma lymfomových buněk je docela bazofilní. Jeden segmentovaný eozinofil vlevo uprostřed. Description: Another example of "villous lymphocytes" in peripheral blood smear (without EDTA). Cytoplasm of the lymphoma cells is quite basophilic. One segmented eosinophil at the middle left.
Type: peripheral blood
Klíčová slova*: lymphocyte atypical
Chronic myelogenous leukaemia - chronic phase
Various stages of maturation in neutrophil lineage (one myeloblast in the centre, two segments and metamyelocyte). Only one early normoblast is under the myeloblast; beside it to the left is basophil. / Různá stádia vyzrávání v neutrofilní řadě (jeden myeloblast v centru, dva segmenty a metamyelocyt). Jen jeden časný normoblast je pod myeloblastem, vedle něj doleva je basofil. Description: Various stages of maturation in neutrophil lineage (one myeloblast in the centre, two segments and metamyelocyte). Only one early normoblast is under the myeloblast; beside it to the left is basophil.
Type: bone marrow
Klíčová slova*: myeloblast, metamyelocyte, basophil, segmented granulocyte, normoblast
Chronic myelogenous leukaemia - chronic phase
Increased number of basophils (upper one at 10 o'clock) and mostly also of eosinophils (lower one at 10 o'clock; there is segmented neutrophil between these two cells) is typical feature of the disease. Eryhtropoiesis is reduced (slide shows no erythroid precursors). / Zvýšený počet basofilů (horní na 10. hodině) a většinou i eozinofilů (dolní na 10. hodině; mezi těmito dvěma buňkami je neutrofilní segment) je typickým rysem choroby. Erytropoéza je snížená (v nátěru nejsou žádná erytroidní prekurzory) Description: Increased number of basophils (upper one at 10 o'clock) and mostly also of eosinophils (lower one at 10 o'clock; there is segmented neutrophil between these two cells) is typical feature of the disease. Eryhtropoiesis is reduced (slide shows no erythroid precursors).
Type: bone marrow
Chronic myelogenous leukaemia - chronic phase
Basophils are almost invariable increased including immature forms in peripheral blood smears (to the right from the middle). Granulocytes show normal maturation. There are numerous thrombocytes in the smear. / Téměř konstantně jsou v nátěrech periferní krve zmnoženy basofily včetně nezralých forem (vpravo od středu). Vyzrávání v granulocytech je normální. V nátěru jsou četné trombocyty. Description: Basophils are almost invariable increased including immature forms in peripheral blood smears (to the right from the middle). Granulocytes show normal maturation. There are numerous thrombocytes in the smear.
Type: peripheral blood
Klíčová slova*: basophil, granulocyte
Hairy cell leukaemia- BM
Another example of hairy cell - oval nucleus, moderate mature chromatin, abundant weakly basophilic cytoplasm with few vacuoles, few inclusions and irregular margins with projections in all circumference of the cell. / Jiný příklad vlasaté buňky - oválné jádro, středně zralý chromatin, bohatá slabě basofilní cytoplazma s několika vakuolami, několika inkluzemi a nepravidelným ohraničením s výběžky po celéom obvodu buňky. Description: Another example of hairy cell - oval nucleus, moderate mature chromatin, abundant weakly basophilic cytoplasm with few vacuoles, few inclusions and irregular margins with projections in all circumference of the cell.
Type: bone marrow
Klíčová slova*: hairy cell, vacuolisation
Hairy cell leukaemia- BM
Smears of bone marrow aspirate use to be pure because aspiration is usually difficult or even impossible. Tumour cells can represent only minority cell population. Cells are the most often medium-size, but larger then normal lymphocyte. They have abundant weakly basophilic cytoplasm with irregular cytoplasmic margins. The cell at upper right contains few cytoplasmic inclusions. / Nátěry z aspirační biospie jsou obvykle chudé protože aspirace je většinou obtížná nebo dokonce nemožná. Nádorové buňky mohou představovat jen minoritní buněčnou populaci. Buňky jsou nejčastěji střední velikosti, ale větší než normální lymfocyt. Mají objemnou slabě basofilní cytoplazmu s nepravidelnými cytoplazmatickými okraji. Buňka vpravo nahoře obsahuje několik cytoplazmatických inkluzí. Description: Smears of bone marrow aspirate use to be pure because aspiration is usually difficult or even impossible. Tumour cells can represent only minority cell population. Cells are the most often medium-size, but larger then normal lymphocyte. They have abundant weakly basophilic cytoplasm with irregular cytoplasmic margins. The cell at upper right contains few cytoplasmic inclusions.
Type: bone marrow
Klíčová slova*: cytoplasmic inclusion, hairy cell
Megaloblastic erythropoiesis- BM
More (at right) or less (at left) mature megaloblasts with abundant cytoplasm. The more mature one contains numerous Howell Jolly bodies. Erythrocyte at the middle left shows basophilic stippling - this picture can be find also in peripheral blood smears. / Více (vpravo) či méně (vlevo) zralé megaloblasty s objemnou cytoplazmou. Ten více zralý obsahuje četná Howell- Jollyho tělíska. Erytrocyt vlevo uprostřed ukazuje basofilní tečkování - tento obraz může být nalezen i v nátěrech periferní krve. Description: More (at right) or less (at left) mature megaloblasts with abundant cytoplasm. The more mature one contains numerous Howell Jolly bodies. Erythrocyte at the middle left shows basophilic stippling - this picture can be find also in peripheral blood smears.
Type: bone marrow
Klíčová slova*: basophilic stippling, Howell-Jolly body
CML accelerated phase - PB
Leucocytosis, left shift. Two blasts at the right side (at 3. o´clock). basophil on the left. Normoblast in the centre, lymphocyte at the right side up. / Leukocytóza, posun doleva. Dva blasty vpravo ( na 3. hodině), bazofil vlevo. Normoblast uprostřed, lymfocyt vpravo nahoře. Description: Leucocytosis, left shift. Two blasts at the right side (at 3. o´clock). basophil on the left. Normoblast in the centre, lymphocyte at the right side up.
Type: peripheral blood
Klíčová slova*: myeloblast, myelocyte, metamyelocyte, basophil, lymphocyte, normoblast
CML accelerated phase - PB
Marked leucocytosis with granulocytosis. Myelocytes and segmented granulocytes are predominant elements of peripheral blood, marked basophilia. At the picture blasts and promyelocytes are present, six basophiles. / Výrazná leukocytóza s granulocytózou. Myelocyty a neutrofilní segmenty jsou dominujícími elementy v nátěrech periferní krve, výrazná bazofílie. Na obrázku přítomny i blasty a promyelocyty, šest bazofilů. Description: Marked leucocytosis with granulocytosis. Myelocytes and segmented granulocytes are predominant elements of peripheral blood, marked basophilia. At the picture blasts and promyelocytes are present, six basophiles.
Type: peripheral blood
Klíčová slova*: myeloblast, promyelocyte, myelocyte, basophil, segmented granulocyte
CML accelerated phase - BM
Hyperplastic bone marrow with increased number of granulopoetic cells, predominant population represent myelocytes and segmented granulocytes, eosinophiles and blasts are increased, basophilia. Two blasts are present - one is in the centre and one is on the right side up (on the 2 o'clock).Two basophiles are present - one is slightly right up and one at the left side bottom. Eosinophil myelocyte is present on the right upper border of the picture. / Hyperplastická kostní dřeň se zmnožením buněk granulopoezy, dominující populací jsou myelocyty a neutrofilní segmenty, zmnoženy blasty, výrazná bazofílie. Přítomny dva blasty, jeden uprostřed a jeden vpravo nahoře( na 2. hodině) a dva bazofily - jeden mírně vpravo nahoře a jeden vlevo dole. Eosinofilní myelocyt je při pravém horním okraji obrázku. Description: Hyperplastic bone marrow with increased number of granulopoetic cells, predominant population represent myelocytes and segmented granulocytes, eosinophiles and blasts are increased, basophilia. Two blasts are present - one is in the centre and one is on the right side up (on the 2 o'clock).Two basophiles are present - one is slightly right up and one at the left side bottom. Eosinophil myelocyte is present on the right upper border of the picture.
Type: bone marrow
CML accelerated phase - BM
Hyperplastic bone marrow with increased number of granulopoetic cells, predominant population represent myelocytes and segmented granulocytes, blasts are increased, marked basophilia. Two blasts are present - one is in the centre bottom and one is on the right side ( on the 2 o'clock).Three basophiles are present - one in the centre and two at the right side of the picture. / Hyperplastická kostní dřeň se zmnožením buněk granulopoezy, dominující populací jsou myelocyty a neutrofilní segmenty, zmnoženy blasty, je výrazná bazofílie. Přítomny dva blasty, jeden dole uprostřed a jeden vpravo ( na 2. hodině). Jsou přítomny tři bazofily - jeden uprostřed a dva na pravé straně obrázku. Description: Hyperplastic bone marrow with increased number of granulopoetic cells, predominant population represent myelocytes and segmented granulocytes, blasts are increased, marked basophilia. Two blasts are present - one is in the centre bottom and one is on the right side ( on the 2 o'clock).Three basophiles are present - one in the centre and two at the right side of the picture.
Type: bone marrow
Klíčová slova*: myeloblast, myelocyte, metamyelocyte, basophil, segmented granulocyte
CML accelerated phase - BM
Hyperplastic bone marrow with increased number of granulopoetic cells, predominant population represent myelocytes and segmented granulocytes, blasts and eosinophiles are increased, marked basophilia. Blasts are in the centre and on the right and left side (at 9 and 2 o'clock), eosinophil is in the centre below segmented granulocyte. Four basophiles are present - two at the right side up and two at the bottom part of the picture. / Hyperplastická kostní dřeň se zmnožením buněk granulopoezy, dominující populací jsou myelocyty a neutrofilní segmenty, zmnoženy blasty a eozinofily, výrazná bazofilie. Blasty uprostřed , dále vlevo i vpravo (na 9.a 2.hodině), eozinofil uprostřed pod neutrofilním segmentem,. Bazofilyjsou přítomny 4, dva vpravo nahoře a dva ve spodní části obrázku. Description: Hyperplastic bone marrow with increased number of granulopoetic cells, predominant population represent myelocytes and segmented granulocytes, blasts and eosinophiles are increased, marked basophilia. Blasts are in the centre and on the right and left side (at 9 and 2 o'clock), eosinophil is in the centre below segmented granulocyte. Four basophiles are present - two at the right side up and two at the bottom part of the picture.
Type: bone marrow
Klíčová slova*: myeloblast, myelocyte, eosinophil, basophil, band, segmented granulocyte
Chronic lymphocytic leukaemia/small lymphocytis lymphoma
Small lymphocytes in CLL use to have round or oval nucleus in excentric position in the cell. Nuclear chromatin is mature, nucleoli are indistinct or absent. Cytoplasm is pure, weakly basophilic, agranular, rarely with some vacuoles (in the middle). Broken cells or smudge cells are characteristic. / Malé lymfocyty u CLL obvykle mají kulaté či ovální jádro excentricky uložené v buňce. Jaderný chromatin je zralý, jadérka jsou nezřetelná nebo nepřítomna. Cytoplazma je chudá, slabě basofilní, agranulární, vzácně s několika vakuolami (uprostřed). Rozbité buňky nebo buňky rozmazané jsou charakteristické. Description: Small lymphocytes in CLL use to have round or oval nucleus in excentric position in the cell. Nuclear chromatin is mature, nucleoli are indistinct or absent. Cytoplasm is pure, weakly basophilic, agranular, rarely with some vacuoles (in the middle). Broken cells or smudge cells are characteristic.
Type: bone marrow
Klíčová slova*: lymphocyte, nuclear shadows
AML M5a
Numerous relatively large monoblasts with round, oval, sporadic lightly lobular nuclei. Nucleoli in this case not clearly seen, cytoplasm moderately basophilic with fine powdering of azurophilic granulastion and with distinct vacuoles. / Četné poměrně velké monoblasty s kulatými, oválnými, ojediněle až lehce laločnatýnmi jádry, jadérka v tomto případě nejsou zřetelná, cytoplasma je středně basofilní s jemným popraškem azurofilních granulací a s patrnými vakuolami. Description: Numerous relatively large monoblasts with round, oval, sporadic lightly lobular nuclei. Nucleoli in this case not clearly seen, cytoplasm moderately basophilic with fine powdering of azurophilic granulastion and with distinct vacuoles.
Type: bone marrow
Klíčová slova*: monoblast
Small- cell bronchial carcinoma - BM
The last example bone marrow tumour cells' infiltration in this case - the cluster of various size tumour cells with immature appearance, narrow rim of basophilic cytoplasm and with fine chromatin and a few nucleoli in nucleus. There are two late erythroblasts at the left side of the picture. / Poslední příklad infiltrace nádorovými buňkami u tohoto případu - trs různě velkých nádorových buněk nezralého vzhledu s úzkým lemem bazofilní cytoplazmy, v jádře jemný chromatin a jadérka. Vlevo jsou dva pozdní erytroblasty. Description: The last example bone marrow tumour cells' infiltration in this case - the cluster of various size tumour cells with immature appearance, narrow rim of basophilic cytoplasm and with fine chromatin and a few nucleoli in nucleus. There are two late erythroblasts at the left side of the picture.
Type: bone marrow
Klíčová slova*: polychromatophilic normoblast, orthochromatophilic normoblast, tumour cell
Small- cell bronchial carcinoma - BM
The first example of the bone marrow infiltration in this case - the cluster of the middle size cells with narrow rim of basophilic cytoplasm; there is fine chromatin and some nucleoli in the nucleus. There is eosinophil metamyelocyte at the upper left, neutrophil metamyelocyte at the upper right and there are two late erythroblasts at the upper part of the picture. Naked nucleoli are the typical content of the smear. / První příklad infiltrace nádorovými buňkami u tohoto případu - trs středně velkých buněk s úzkým lemem bazofilní cytoplamy; v jádře je jemný chromatin a jadérka. Vlevo nahoře eosinofilní metamyelocyt, vpravo nahoře neutrofilní metamyelocyt, v horní části obrázku dva pozdní erytroblasty. Holá jádra jsou typickou součástí nátěru. Description: The first example of the bone marrow infiltration in this case - the cluster of the middle size cells with narrow rim of basophilic cytoplasm; there is fine chromatin and some nucleoli in the nucleus. There is eosinophil metamyelocyte at the upper left, neutrophil metamyelocyte at the upper right and there are two late erythroblasts at the upper part of the picture. Naked nucleoli are the typical content of the smear.
Type: bone marrow
Klíčová slova*: metamyelocyte, orthochromatophilic normoblast, naked nucleus, tumour cell
AML M5b bone marrow
Monoblasts can have deeply basophilic and vacuolized cytoplasm (two cells at right). They can even resemble Burkitt lymphoma's cells. / Monoblasty mohou mít tmavě basofilní a vakuolizovanou cytoplazmu (dvě buňky vpravo). Mohou dokonce připomínat buňky Burkitova lymfomu. Description: Monoblasts can have deeply basophilic and vacuolized cytoplasm (two cells at right). They can even resemble Burkitt lymphoma's cells.
Type: bone marrow
Klíčová slova*: monoblast
AML M5b peripheral blood
Monoblasts at peripheral blood smear. Their cytoplasm is abundant, vacuolized and intensely (at right) to moderate (at left) basophilic. Nuclei are rather round with delicate chromatin and prominent nucleoli. / Monoblasty v periferní krvi. Jejich cytoplazma je bohatá, vakuolizovaná a intenzivně (vpravo) až středně (vlevo) basofilní. Jádra jsou spíše kulatá s jemným chromatinem a prominujícími jadérky. Description: Monoblasts at peripheral blood smear. Their cytoplasm is abundant, vacuolized and intensely (at right) to moderate (at left) basophilic. Nuclei are rather round with delicate chromatin and prominent nucleoli.
Type: peripheral blood
Klíčová slova*: monoblast
AML M5b peripheral blood
One segmented neutrophil and two atypical monocytes - they have more basophilic cytoplasm and lower one has obvious and large nulceoli. / Jeden neutrofilní segment a dva atypické monocyty - mají více basofilní cytoplazma a spodní má jasná a velká jadérka. Description: One segmented neutrophil and two atypical monocytes - they have more basophilic cytoplasm and lower one has obvious and large nulceoli.
Type: peripheral blood
Klíčová slova*: segmented granulocyte, monocyte
MDS RAEB I- bone marrow
Poly-nuclear form of basophilic megakaryocyte 8N (N=number of sets of chromosomes) with really immature nuclei - fine chromatin, multiple nucleoli. / Vícejaderná forma basofilního megakaryocytu 8N (Ń=počet chromosomových sad) se skutečně nezralými jádry - jemný chromatin, vícečetná jadérka. Description: Poly-nuclear form of basophilic megakaryocyte 8N (N=number of sets of chromosomes) with really immature nuclei - fine chromatin, multiple nucleoli.
Type: bone marrow
Klíčová slova*: megakaryocyte
MDS RAEB I- bone marrow
Early megaloblast (at right) and dysplastic late erythroblast (at left; it has non-round nucleus and basophilic stippling). Myeloblast with some azurophilic granules in Golgi zone is under the megaloblast. / Časný megaloblast (vpravo) a dysplastický pozdní erytroblast (vlevo; má zneokrouhlené jádro a basofilní tečkování). Myeloblast s několika azurofilními granuly v Golgiho zóně je pod megaloblastem. Description: Early megaloblast (at right) and dysplastic late erythroblast (at left; it has non-round nucleus and basophilic stippling). Myeloblast with some azurophilic granules in Golgi zone is under the megaloblast.
Type: bone marrow
Klíčová slova*: myeloblast, erythroblast, megaloblast
MDS RAEB I- bone marrow
Dysplastic bi-nucleated erythroblasts (they are oxyphil with basophilic stippling, abundant cytoplasm, nuclei have different size and relatively immature chromatin). Megakaryoblast with cytoplasmic blebs is above the centre of the picture. / Dysplastické dvojjaderné erytroblasty (jsou oxyfilní s basofilním tečkováním, objemnou cytoplazmou, jádra mají rozdílnou velikost a relativně nezralý chromatin). Megakaryoblast s cytoplazmatickými "puchýřky" je nad středem obrázku. Description: Dysplastic bi-nucleated erythroblasts (they are oxyphil with basophilic stippling, abundant cytoplasm, nuclei have different size and relatively immature chromatin). Megakaryoblast with cytoplasmic blebs is above the centre of the picture.
Type: bone marrow
Klíčová slova*: megakaryoblast, erythroblast
AML M5a peripheral blood
Six blasts with weakly to strong basophilic rather voluminous cytoplasm. Rest of the cells are promonocytes, destroyed cells, naked nuclei and one plasma cell (at 3 o'clock). / Šest blastů se slabě až silně basofilní spíše objemnou cytoplazmou. Zbytek buněk jsou promonocyty, rozbité buňky, holá jádra a jeden plazmocyt (na 3. hodině). Description: Six blasts with weakly to strong basophilic rather voluminous cytoplasm. Rest of the cells are promonocytes, destroyed cells, naked nuclei and one plasma cell (at 3 o'clock).
Type: peripheral blood
Klíčová slova*: monoblast, promonocyte, plasma cell
AMML Eo bone marrow
Blasts and promonocytes, eosinophils with atypical "basophil like" granulation. One promyelocyte at 5 o' clock. Eosinophil component reaches almost 14% of nucleated bone marrow cells. / Blasty a promonocyty, eozinofily s atypickou granulací napodobující "basofilní". Jeden promyelocyt na 5. hodině. Eozinofilní komponenta dosahuje téměř 14% z jaderných buněk kostní dřeně. Description: Blasts and promonocytes, eosinophils with atypical "basophil like" granulation. One promyelocyte at 5 o' clock. Eosinophil component reaches almost 14% of nucleated bone marrow cells.
Type: bone marrow
Klíčová slova*: eosinophil, promonocyte
AMML Eo bone marrow
Several blasts with heterogeneous morphology, one monocyte and two eosinophils. This one at the left is really immature (promyelocyte), has a few large granules purple-violet in colour reminding basophilic granulation mixing with eosinophlic granules. Naked nuclei and damaged cells. / Několik blastů různorodé morfologie, jeden monocyt a dva eozinofily. Ten vlevo je skutečně nezralý (promyelocyt), má několik velkých granulí purpurově-fialové barvy připomínající basofilní granulaci smíchaných s granulemi eozinofilními. Holá jádra a poškozené buňky. Description: Several blasts with heterogeneous morphology, one monocyte and two eosinophils. This one at the left is really immature (promyelocyte), has a few large granules purple-violet in colour reminding basophilic granulation mixing with eosinophlic granules. Naked nuclei and damaged cells.
Type: bone marrow
Klíčová slova*: myeloblast, eosinophil, monocyte
Cabot´s rings
Centre red blood cell with nucleus remnant, surrouned with a Cabot´s ring. Basophilic stipling as an adjoining find. / V centru erytrocyt se zbytkem jádra, který je obklopen Cabotovým prstencem. Kromě toho vidíme v krvince basofilní tečkování. Description: Centre red blood cell with nucleus remnant, surrouned with a Cabot´s ring. Basophilic stipling as an adjoining find.
Type: bone marrow
Klíčová slova*: basophilic stippling, Cabot ring
APL- peripheral blood 5
At top is abnormal promyelocyte with large numerous granules, in comparison below is mature basophil. / Nahoře abnormální promyelocyt s objemnou početnou granulací, ke srovnání dole zralý bazofil. Description: At top is abnormal promyelocyte with large numerous granules, in comparison below is mature basophil.
Type: peripheral blood
Klíčová slova*: promyelocyte, basophil
CML - peripheral blood
Leukocytosis, left shift in neutrophil maturation and one basophil. (at the 11 o'clock). / Leukocytóza, posun doleva a jeden bazofil (na 11. hodině). Description: Leukocytosis, left shift in neutrophil maturation and one basophil. (at the 11 o'clock).
Type: peripheral blood
Klíčová slova*: basophil
CML - bone marrow
Granulocytic hyperplasia - some eosinophils and basophils, predominant cells are mature neutrophils and myelocytes. Smear do not shows any marked dysplastic changes but one hypo-granular pseudo-pelgeroid segmented neutrophil (underneath centre of the picture at the 5 o'clock). / Granulocytární hyperplázie - několik eozinoiflů a bazofilů, dominujícími buňkami jsou zralé neutrofily a myelocyty. Nátěr neukazuje žádné zřetelné dysplastické změny s výjimkou jednoho hypogranulárního pseudo-pelgeroidního neutrofilního segmentu (pod centrem obrázku na 5. hodině). Description: Granulocytic hyperplasia - some eosinophils and basophils, predominant cells are mature neutrophils and myelocytes. Smear do not shows any marked dysplastic changes but one hypo-granular pseudo-pelgeroid segmented neutrophil (underneath centre of the picture at the 5 o'clock).
Type: bone marrow
Klíčová slova*: myelocyte, eosinophil, basophil, segmented granulocyte, pseudo-Pelger anomaly, hypogranulation
CML - peripheral blood
Smear shows numerous myelocytes and segmented neutrophils. One basophil at the 8 o'clock. / Nátěr ukazuje četné myelocyty a neutrofilní segmenty. Jeden basofil na 8. hodině. Description: Smear shows numerous myelocytes and segmented neutrophils. One basophil at the 8 o'clock.
Type: peripheral blood
Klíčová slova*: myelocyte, basophil, segmented granulocyte
CML - peripheral blood
In the middle of the picture are myelocytes, segmented neutrophils and two rather immature eosinophils. Mature basophil is on the left. / Uprostřed obrázku jsou myelocyty, neutrofilní segmenty a dva spíše nezralé eozinofily. Zralý basofil je nalevo. Description: In the middle of the picture are myelocytes, segmented neutrophils and two rather immature eosinophils. Mature basophil is on the left.
Type: peripheral blood
Klíčová slova*: myelocyte, eosinophil, basophil, segmented granulocyte
Ewing´s sarcoma-BM metastasis
A group of Ewings sarcoma cells, indistinct intercellular borders. Large cellular nuclei with visible nucleoli, smaler cells without visible nucleoli. Light basophillic colored cytoplasm containing basophillic inclusions, not typical for thisdiagnosis. Vacuoles in the cytoplasm of some cells. / Ložisko buněk Ewingova sarkomu. Hranice mezi buńkami nezřetelné. Větší buněčná jádra s patrnými jadérky, menší bez patrných jadérek. Světle basofilní cytoplasma obsahuje místy tmavé basofilní inkluze, netypické pro diagnosu. V cytoplasmě některých buněk vakuoly. Description: A group of Ewings sarcoma cells, indistinct intercellular borders. Large cellular nuclei with visible nucleoli, smaler cells without visible nucleoli. Light basophillic colored cytoplasm containing basophillic inclusions, not typical for thisdiagnosis. Vacuoles in the cytoplasm of some cells.
Type: bone marrow
Klíčová slova*: lymphoblast
RMS
A group of rhabdomyosarcoma cells with significant variability of shape and size and various numbers of vacuoles. The nuclear chromatin in small cells is condensed, in the large cell more smooth. The cytoplasm is basophilic, in some cells with a perinuclear acidophilic zone. / Skupina buněk rhabdomyosarkomu značně variabilní velikosti a tvaru, s větším, či menším počtem vakuol v cytoplasmě. Jádra malých bb. mají chromatin kondenzovaný, u velké b. je hrubě zrnitý. Cytoplasma basofilní, u některých bb. je perinukleární acidofilní dvorec. Description: A group of rhabdomyosarcoma cells with significant variability of shape and size and various numbers of vacuoles. The nuclear chromatin in small cells is condensed, in the large cell more smooth. The cytoplasm is basophilic, in some cells with a perinuclear acidophilic zone.
Type: bone marrow
RMS
Rosette - shaped rhabdomyoblasts, Upward probably one multinuclear cell, downward on the left binucleated cell. All cells with abundant vacuolised cytoplasm. The peripheral cytoplasm is basophilic, the perinuclear zone in some cells acidophilic. / rozetovitě uspořádané rhabdomyoblasty, buňky v horní částií spíše splývají, snad jde o jednu vícejadernou b., vlevo dole buňka dvoujaderná, cytoplasma je ve všech buňkách bohatě vakuolizována, na periferii basofilní, perinukleárně u některých bb. acidofilní Description: Rosette - shaped rhabdomyoblasts, Upward probably one multinuclear cell, downward on the left binucleated cell. All cells with abundant vacuolised cytoplasm. The peripheral cytoplasm is basophilic, the perinuclear zone in some cells acidophilic.
Type: bone marrow
RMS
Centrally a rhabdomyoblast with a large nucleus and abundant vacuolised cytoplasma. The peripheral cytoplasm is basophilic, in the perinuclear zone acidophilic. Nuclear chromatin is granular. / V centru rhabdomyoblast s velkým jádrem a bohatou, vakuolizovanou cytoplasmou. Cytoplasma je na periferii basofilní, perinukleárně acidofilní. Jaderný chromatin je hrubě granulární. Description: Centrally a rhabdomyoblast with a large nucleus and abundant vacuolised cytoplasma. The peripheral cytoplasm is basophilic, in the perinuclear zone acidophilic. Nuclear chromatin is granular.
Type: bone marrow
AML M4 EO, BM
Myeloid and monocytic blast cells, on the right side 3 immature eosinophiles. Note large basophilic granules in adition to eosinophilic ones in cells seen on the right.. / Na obrázku myeloidní a monocytoidní blastické bb. V pravé polovině 3 mladé Eo, vpravo nahoře a vpravo dole bb., které mají kromě eosinofilních i velká basofilní granula. Description: Myeloid and monocytic blast cells, on the right side 3 immature eosinophiles. Note large basophilic granules in adition to eosinophilic ones in cells seen on the right..
Type: bone marrow
Klíčová slova*: myeloblast, metamyelocyte, eosinophil, monoblast
AML M4 EO, BM
Upwards on the left and in the centre note immature eosiniphils showing double granulation i.e. eosinophilic and large basophilic granules, typical for M4 Eo. Downwards a monocyte is seen. / Vlevo nahoře a uprostřed obrázku nezralý Eo s dvojí granulací, t.j. kromě eosinofilních granul i velká tmavá basofilní granula, typická pro Eo u M4 Eo. V horní části monocyt. Description: Upwards on the left and in the centre note immature eosiniphils showing double granulation i.e. eosinophilic and large basophilic granules, typical for M4 Eo. Downwards a monocyte is seen.
Type: bone marrow
Klíčová slova*: myelocyte, eosinophil