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208 cs: May-Hegglinova anomálie
en: May-Hegglin anomaly 		3 S. Valníček, Bára Jordanová 22.1.2010, 10:13 1.7.2010, 11:01 1.7.2010, 11:01 Jan Blatný
44 cs: Chronická myeloidní leukémie - chronická fáze
en: Chronic myelogenous leukaemia - chronic phase 		4 A. Buliková 8.12.2006, 20:03 2.10.2007, 13:11 2.10.2007, 13:11 J. Kissová


Nalezené obrázky* (n=37)

May-Hegglin anomaly
In both granulocytes on the picture you can see light-blue inclusion-bodies, typical for MHA neutrophilic granulocytes In the left cell it is localised in the center, in the right cell in its upper part. / V obou granulocytech na obrázku jsou světlemodrá inklusní tělíska, typická pro neutrofilní granulocyty MHA, u levého uprostřed buňky, u pravého při hormím okraji buňky. Description: In both granulocytes on the picture you can see light-blue inclusion-bodies, typical for MHA neutrophilic granulocytes In the left cell it is localised in the center, in the right cell in its upper part.
Type: peripheral blood
Klíčová slova*: Doehle body
May-Hegglin anomaly
Centrally in a neutrophilic granulocyte you can see a paragranular localised unclear light-blue inclusion body and in the lower part of the picture there is a giant platelet (macrophtopmbocyte). Both of these phenomenons are typical for MHA. / Uprostřed obrázku vidíme v neutrofilním granulocytu paragranulárně vpravo nejasné inklusní tělísko světlemodré barvy. Na dolním okraji velký tromocyt ( makrotrombocyt ). Oba tyto jevy jsou typické pro MHA. Description: Centrally in a neutrophilic granulocyte you can see a paragranular localised unclear light-blue inclusion body and in the lower part of the picture there is a giant platelet (macrophtopmbocyte). Both of these phenomenons are typical for MHA.
Type: peripheral blood
Klíčová slova*: Doehle body, macrothrombocyte
May-Hegglin anomaly
In the middle of a neutrophilic granulocyte you can see a paranuclear blue inclusion body among the neutrophilic granules, morphologicaly corresponding to Doehle body, typical for MHA granulocytes. / V neutrofilním granulocytu uprostřed obrázku vidíme mezi neutrofilními granuly paranukleárně vpravo světlemodré inklusní tělísko, morfologicky odpovídající Doehleho inklusím, které je typické pro neutrofilní granulocyty u MHA. Description: In the middle of a neutrophilic granulocyte you can see a paranuclear blue inclusion body among the neutrophilic granules, morphologicaly corresponding to Doehle body, typical for MHA granulocytes.
Type: peripheral blood
Klíčová slova*: Doehle body
AML without maturation- BM
Hypercellular bone marrow with dominant population of myeloblasts. Only one segmented neutrophil is above the picture's centre, it is hypogranular. There is also one mature plasmocyte at 11 o'clock. Due to rich smear not all cells can be definitely distinguished. / Hypercelulární kostní dřen s převažující populací myeloblastů. Jen jeden neutrofilní segment je nad středem obráźku, je hypogranulovaný. Jeden zralý plazmocyt je také na 11. hodině. Z důvodů bohatého nátěru ne všechny buňky mohou být s jistotou rozpoznány. Description: Hypercellular bone marrow with dominant population of myeloblasts. Only one segmented neutrophil is above the picture's centre, it is hypogranular. There is also one mature plasmocyte at 11 o'clock. Due to rich smear not all cells can be definitely distinguished.
Type: bone marrow
Klíčová slova*: myeloblast, segmented granulocyte, plasma cell
AML with multilineage dysplasia - BM
The myeloblasts are the most frequent cells of the picture, some of them are in mitosis. In erythroid lineage are megaloblastoid features - markedly expressed in two cells at 4-5 o'clock. Hypogranulation is in neutrophils. / Myeloblasty jsou nejčastějšími buňkami obrázku, některé z nich jsou v mitóze. V erytroidní řadě jsou megaloblastoidní rysy - zřetelně vyjádřeny ve dvou buňkách na 4-5. hodině. Hypogranulace je v neutrofilech. Description: The myeloblasts are the most frequent cells of the picture, some of them are in mitosis. In erythroid lineage are megaloblastoid features - markedly expressed in two cells at 4-5 o'clock. Hypogranulation is in neutrophils.
Type: bone marrow
Klíčová slova*: myeloblast, hypogranulation, megaloblastic haematopoiesis
Medulloblastom
BM metastasis.Large cluster of malignant cells with polymorphic cellular and nuclear shape and size.Nuclei rather eccentrically located, irregular or lobed, some with large nuclei.Marked vacuoles of basophilic cytoplasm and also of some of the nuclei.Left upper part of the picture shows a segmented neutrophile and a hypogranular myelocyte. / Metastáza v KD.Velký shluk maligních buněk, zřetelná polymorfie tvaru a velikosti buněk i jader,zejména ve srovnání s neuroblastomem. Jádra spíše excentricky uložena,nepravidel- ná,až laločnatá,oj.s velkými jadérky.Cytoplasma basofilní, výrazně vakuolizovaná,částečně i vakuolizace jader.Vlevo nahoře segmentovaný neutrofil a hypogranulární myeolocyt. Description: BM metastasis.Large cluster of malignant cells with polymorphic cellular and nuclear shape and size.Nuclei rather eccentrically located, irregular or lobed, some with large nuclei.Marked vacuoles of basophilic cytoplasm and also of some of the nuclei.Left upper part of the picture shows a segmented neutrophile and a hypogranular myelocyte.
Type: bone marrow
Klíčová slova*: tumour cell
Anaplastic large cell lymphoma - ALK negative
Three tumour cells in ALCL. They have pale basophilic cytoplasm, fine reticular nuclear chromatin and few dark blue nucleoli. There are two nuclear fragments in cytoplasm one of them (upper left). At the upper right are two immature neutrophils (upper promyelocyte, lower myelocyte). / Tři nádorové buňky u ALCL. Mají světle bazofilní cytoplazmu, jemný síťovitý jaderný chromatin a několik tmavě modrých jadérek. V cytoplazmě jedné z nich jsou dva jaderné fragmenty (nahoře vlevo). Nahoře vpravo jsou dva nezralé neutrofily (horní promyelocyt, dolní myelocyt). Description: Three tumour cells in ALCL. They have pale basophilic cytoplasm, fine reticular nuclear chromatin and few dark blue nucleoli. There are two nuclear fragments in cytoplasm one of them (upper left). At the upper right are two immature neutrophils (upper promyelocyte, lower myelocyte).
Type: bone marrow
Klíčová slova*: promyelocyte, myelocyte, tumour cell
Anaplastic large cell lymphoma - ALK negative
One tumour cell in ALCL (middle right) - large cell with fine nuclear chromatin, prominent nucleolus, abundant cytoplasm which basophilia passes to eosinophilia. There are also three neutrophil myelocytes (upper one is destroyed), one lymphocyte (at 3 o'clock). The last cell in the picture is macrophage (between two myelocytes). These cells are typical component of this lymphohistiocytic variant of the lymphoma . / Jedna nádorová buňka u ALCL (ve středu vpravo) - velká buňka s jemným jaderným chromatinem, prominujícím jadérkem, bohatou cytoplazmou jejíž basofilie přechází do eozinofilie. Také jsou zde tři neutrofilní myelocyty (horní je poškozený), jeden lymfocyt (na 3. hodině). Poslední buňkou na obrázku je makrofág (mezi dvěma myelocyty). Tyto buňky jsou typickou součástí této lymfohistiocytární varianty lymfomu. Description: One tumour cell in ALCL (middle right) - large cell with fine nuclear chromatin, prominent nucleolus, abundant cytoplasm which basophilia passes to eosinophilia. There are also three neutrophil myelocytes (upper one is destroyed), one lymphocyte (at 3 o'clock). The last cell in the picture is macrophage (between two myelocytes). These cells are typical component of this lymphohistiocytic variant of the lymphoma .
Type: bone marrow
Klíčová slova*: myelocyte, macrophage, tumour cell
Anaplastic large cell lymphoma - ALK negative
Two lymphoma cells are in the picture. One of them is large with almost round nucleus with fine chromatin and prominent nucleoli, abundant basophilic cytoplasm converts to more basophilic at the right perinuclear area. Another lymphoma cell is smaller (at 8 o'clock) with ex-centric nucleus. It contains fine chromatin and 2 to 3 small nucleoli. Other cells of the picture belong to neutrophil lineage including one mitosis (at the right from the centre). There is one monocyte above at large lymphoma cell. / Na obrázku jsou dvě lymfomové buňky. Jedna z nich je velká s téměř kulatým jádrem, s jemným jaderným chromatinem a prominujícími jadérky, bohatá bazofilní cytoplazma se mění ve více eozinofilní v pravé perinukleární oblasti. Jiná lymfomová buňka (na 8. hodině) je menší s excentrickým jádrem. Obsahuje jemný jaderný chromatin a 2-3 malá jadérka. Další buňky na obrázku patří neutrofilní řadě včetně jedné mitózy (napravo od středu). Jeden monocyt je nad velkou lymfomovou buňkou. Description: Two lymphoma cells are in the picture. One of them is large with almost round nucleus with fine chromatin and prominent nucleoli, abundant basophilic cytoplasm converts to more basophilic at the right perinuclear area. Another lymphoma cell is smaller (at 8 o'clock) with ex-centric nucleus. It contains fine chromatin and 2 to 3 small nucleoli. Other cells of the picture belong to neutrophil lineage including one mitosis (at the right from the centre). There is one monocyte above at large lymphoma cell.
Type: bone marrow
Klíčová slova*: monocyte, lymphocyte atypical
Splenic marginal zone B- cell lymphoma
Numerous villous lymphocytes in bone marrow smear. Some show nucleoli in their nuclei. There is segmented neutrophil underneath the centre of the picture and one large granular lymphocyte at 5 o' clock. / Početné vilózní lymfocyty v nátěru kostní dřeně. Některé mají jadérka v jádrech. Jeden neutrofilní segment je pod středem obrázku a velký granulovaný lymfocyt na 5. hodině. Description: Numerous villous lymphocytes in bone marrow smear. Some show nucleoli in their nuclei. There is segmented neutrophil underneath the centre of the picture and one large granular lymphocyte at 5 o' clock.
Type: bone marrow
Klíčová slova*: large granular lymphocyte, lymphocyte atypical
Chronic myelogenous leukaemia - chronic phase
Various stages of maturation in neutrophil lineage (one myeloblast in the centre, two segments and metamyelocyte). Only one early normoblast is under the myeloblast; beside it to the left is basophil. / Různá stádia vyzrávání v neutrofilní řadě (jeden myeloblast v centru, dva segmenty a metamyelocyt). Jen jeden časný normoblast je pod myeloblastem, vedle něj doleva je basofil. Description: Various stages of maturation in neutrophil lineage (one myeloblast in the centre, two segments and metamyelocyte). Only one early normoblast is under the myeloblast; beside it to the left is basophil.
Type: bone marrow
Klíčová slova*: myeloblast, metamyelocyte, basophil, segmented granulocyte, normoblast
Chronic myelogenous leukaemia - chronic phase
Excess of granulocytic cells - the most of them are neutrophils in different stage of maturation including segmented ones, only two are eosinophils (one to the middle left and one to the middle right). Only one late erythroblast with pycnotic nucleus is underneath the centre of the picture. / Převaha buněk granulocytární řady - většina z nich jsou neutrofily v různém stadiu vývoje včetně segmentů, jen dva jsou eozinofily (jeden ze středu doleva a jeden ze středu doprava). Jen jeden pozdní erytroblast s pyknotickým jádrem je pod centrem obrázku. Description: Excess of granulocytic cells - the most of them are neutrophils in different stage of maturation including segmented ones, only two are eosinophils (one to the middle left and one to the middle right). Only one late erythroblast with pycnotic nucleus is underneath the centre of the picture.
Type: bone marrow
Klíčová slova*: eosinophil, normoblast
Chronic myelogenous leukaemia - chronic phase
Increased number of basophils (upper one at 10 o'clock) and mostly also of eosinophils (lower one at 10 o'clock; there is segmented neutrophil between these two cells) is typical feature of the disease. Eryhtropoiesis is reduced (slide shows no erythroid precursors). / Zvýšený počet basofilů (horní na 10. hodině) a většinou i eozinofilů (dolní na 10. hodině; mezi těmito dvěma buňkami je neutrofilní segment) je typickým rysem choroby. Erytropoéza je snížená (v nátěru nejsou žádná erytroidní prekurzory) Description: Increased number of basophils (upper one at 10 o'clock) and mostly also of eosinophils (lower one at 10 o'clock; there is segmented neutrophil between these two cells) is typical feature of the disease. Eryhtropoiesis is reduced (slide shows no erythroid precursors).
Type: bone marrow
Chronic myelogenous leukaemia - chronic phase
Hyperplastic bone marrow with increased number of neutrophil segment and their precursors. Maturation pattern is similar to that in perifpheral blood - predominant populations represent mature neutrophils and myelocytes. There are three eosinofiphils in this part of slide (at 9, 3 and 4 o'clock). There isn't presence of significant dysgranulopoiesis . / Hyperplastická kostní dřeň se zvýšeným počtem neutrofilních segmentů a jejich prekurzorů. Rozložení vyzrávání je obdobné jako v periferní krvi - dominující populace jsou představovány zralými neutrofily a myelocyty. V této části nátěru jsou tři eozinofily (na 9., 3. a 4. hodině). Není přítomna zřetelná dysgranulopoéza. Description: Hyperplastic bone marrow with increased number of neutrophil segment and their precursors. Maturation pattern is similar to that in perifpheral blood - predominant populations represent mature neutrophils and myelocytes. There are three eosinofiphils in this part of slide (at 9, 3 and 4 o'clock). There isn't presence of significant dysgranulopoiesis .
Type: bone marrow
Klíčová slova*: myelocyte, eosinophil, segmented granulocyte
Chronic myelogenous leukaemia - chronic phase
Although predominant populations in peripheral blood smears in the disease represent mature segmented neutrophils and myelocytes, all type of immature cells of granulocytic lineage can occur. There are two bands in the picture (2 o'clock and 7 o'clock), and there is one promyelocyte (at 8 o'clock). / I když dominujícími populacemi u této choroby jsou v nátěru periferní krve neutrofilní segmenty a myelocyty, mohou se objevit všechny nezralé buňky granulocytární řady. Na obrázku jsou dvě tyče (na 2. a 7. hodině) a promyelocyt (na 8. hodině). Description: Although predominant populations in peripheral blood smears in the disease represent mature segmented neutrophils and myelocytes, all type of immature cells of granulocytic lineage can occur. There are two bands in the picture (2 o'clock and 7 o'clock), and there is one promyelocyte (at 8 o'clock).
Type: peripheral blood
Klíčová slova*: promyelocyte, myelocyte, band, segmented granulocyte
Chronic myelogenous leukaemia - chronic phase
Peripheral blood smear shows numerous granulocytes with predominate segmented neutrophils and myelocytes (four of them are in the picture). / Nátěry periferní krve ukazují početné granulocyty s predominancí segmentovaných neutrofilů a myelocytů (čtyři na obrázku). Description: Peripheral blood smear shows numerous granulocytes with predominate segmented neutrophils and myelocytes (four of them are in the picture).
Type: peripheral blood
Klíčová slova*: myelocyte, segmented granulocyte
Megaloblastic haematopoiesis- PB
The presence of hypersegmented neutrophils is highly suggestive of megaloblastic haematopoiesis in peripheral blood smear although not patognomic. It persists for a week or more after commencement of of vitamin B12 or folic acid therapy. / Přítomnost hypersegmentovaných neutrofilů v nátěru periferní krve je vysoce suspektní z megaloblastické hematopoézy, i když ne patognomická. Přetrvává týden i více po zavedení léčby vitamínem B12 či kyselinou listovou. Description: The presence of hypersegmented neutrophils is highly suggestive of megaloblastic haematopoiesis in peripheral blood smear although not patognomic. It persists for a week or more after commencement of of vitamin B12 or folic acid therapy.
Type: peripheral blood
Klíčová slova*: hypersegmentation
Megaloblastic haematopoiesis- BM
Giant metamyelocytes and bands in neutrophil series are usually present. Detection of these cells is diagnostically important in cases, when megaloblastic features of erythropoiesis are masked by co-existing iron deficiency. Granulopoiesis use to be also hyperplastic in bone marrow, although less so than erythropoiesis. / V neutrofilní řadě jsou obvykle jsou přítomny velké metamyelocyty a tyče. Detekce těchto buněk je diagnosticky důležitá v případech, kdy jsou megaloblastické rysy erytropoézy maskovány současně přítomným nedostatkem železa. Granulopoéza je v kostní dřeni rovněž zmnožena, i když méně nežli erytropoéza. Description: Giant metamyelocytes and bands in neutrophil series are usually present. Detection of these cells is diagnostically important in cases, when megaloblastic features of erythropoiesis are masked by co-existing iron deficiency. Granulopoiesis use to be also hyperplastic in bone marrow, although less so than erythropoiesis.
Type: bone marrow
Klíčová slova*: giant band cell, giant metamyelocyte
Megaloblastic haematopoiesis- BM
There is the giant metamyelocyte at 6 o'clock at a typical change in granulocytic lineage. It is approximately twice times the size of a normal metamyelocyte with abnormal shape of nuclei. There is a hypersegmented neutrophil at right. / Na 6. hodině je gigantický metamyelocyt jako typická změna v granulocytární řadě. Je přibližně dvakrát větší nežli normální metamyelocyt s abnormálním tvarem jádra. Vpravo je hypersegmentovaný neutrofil. Description: There is the giant metamyelocyte at 6 o'clock at a typical change in granulocytic lineage. It is approximately twice times the size of a normal metamyelocyte with abnormal shape of nuclei. There is a hypersegmented neutrophil at right.
Type: bone marrow
Klíčová slova*: metamyelocyte, giant metamyelocyte
CML accelerated phase - PB
Predominance of segmented granulocytes, neutrophil band in the centre, eosinophil myelocyte at the right side bottom, cluster of three blasts in the centre. / Převaha neutrofilních segmentů, neutrofilní tyč uprostřed, eozinofilní myelocyt vpravo dole, shluk tří blastů uprostřed. Description: Predominance of segmented granulocytes, neutrophil band in the centre, eosinophil myelocyte at the right side bottom, cluster of three blasts in the centre.
Type: peripheral blood
Klíčová slova*: myeloblast, eosinophil, band, segmented granulocyte
Chronická lymfatická leukémie/malobuněčný lymfom
Numerous small lymphocytes and one segmented neutrophil (at 6 o'clock). Broken cell are typically seen in the smears. They are characteristic but nor pathognomic since they are occasionally seen in a variety other conditions. But only in CLL they are known as "Gumprecht's shades". / Početné malé lymfocyty a jeden neutrofilní segment (na 6. hodině). Rozbité buňky jsou typicky patrné v nátěrech. Jsou charakteristické ale ne patognomické, protože je možné je občas najít i u různých jiných stavů. Avšak jen u CLL jsou známy jako "Gumprechtovy stíny". Description: Numerous small lymphocytes and one segmented neutrophil (at 6 o'clock). Broken cell are typically seen in the smears. They are characteristic but nor pathognomic since they are occasionally seen in a variety other conditions. But only in CLL they are known as "Gumprecht's shades".
Type: bone marrow
Klíčová slova*: segmented granulocyte, lymphocyte, nuclear shadows
Small- cell bronchial carcinoma - BM
Tumour cells' infiltration of the bone marrow - cluster of smaller to middle size cells with high nucleus - cytoplasm ratio, there is fine chromatin in the nucleus with one to more nucleoli. There is one hypergranular neutrophile myelocyte at left side, segmented neuthrophil with pseudo-pelgeroid appearance at the top and late erythroblast at the upper left, there are same naked nucleoli at the smear. / Infiltrace nádorovými buňkami - trs menších a středně velkých buněk s vysokým poměrem jádra a cytoplazmy, v jádře jemný chromatin s jedním až několika jadérky. Vlevo je jeden hypergranulovaný neutrofilní myelocyt, nahoře neutrofilní segment pseudo-pelgeroidního vzhledu a vpravo nahoře pozdní erytroblast, v nátěru je také několik holých jader. Description: Tumour cells' infiltration of the bone marrow - cluster of smaller to middle size cells with high nucleus - cytoplasm ratio, there is fine chromatin in the nucleus with one to more nucleoli. There is one hypergranular neutrophile myelocyte at left side, segmented neuthrophil with pseudo-pelgeroid appearance at the top and late erythroblast at the upper left, there are same naked nucleoli at the smear.
Type: bone marrow
Klíčová slova*: myelocyte, orthochromatophilic normoblast, hypergranulation, naked nucleus, tumour cell
Small- cell bronchial carcinoma - BM
The first example of the bone marrow infiltration in this case - the cluster of the middle size cells with narrow rim of basophilic cytoplasm; there is fine chromatin and some nucleoli in the nucleus. There is eosinophil metamyelocyte at the upper left, neutrophil metamyelocyte at the upper right and there are two late erythroblasts at the upper part of the picture. Naked nucleoli are the typical content of the smear. / První příklad infiltrace nádorovými buňkami u tohoto případu - trs středně velkých buněk s úzkým lemem bazofilní cytoplamy; v jádře je jemný chromatin a jadérka. Vlevo nahoře eosinofilní metamyelocyt, vpravo nahoře neutrofilní metamyelocyt, v horní části obrázku dva pozdní erytroblasty. Holá jádra jsou typickou součástí nátěru. Description: The first example of the bone marrow infiltration in this case - the cluster of the middle size cells with narrow rim of basophilic cytoplasm; there is fine chromatin and some nucleoli in the nucleus. There is eosinophil metamyelocyte at the upper left, neutrophil metamyelocyte at the upper right and there are two late erythroblasts at the upper part of the picture. Naked nucleoli are the typical content of the smear.
Type: bone marrow
Klíčová slova*: metamyelocyte, orthochromatophilic normoblast, naked nucleus, tumour cell
AML M5b bone marrow
All cells belong to monocytic lineage. There is consumed segmented neutrophil in the centre cell. / Všechny buňky patří k monocytární řadě. V buňce uprostřed je pozřený neutrofilní segment. Description: All cells belong to monocytic lineage. There is consumed segmented neutrophil in the centre cell.
Type: bone marrow
Klíčová slova*: hemophagocytosis
AML M5b bone marrow
Promonocytes, monocytes and one monoblast (at 5 o'clock). The presence of neutrophil cells can be rarely find (segmented neutrophil at 11 o'clock). Monocytic lineage represents > 80% nucleated bone marrow cells. / Promonocyty, monocyty a jeden monoblast (na 5. hodině). Vzácně může být zastižena přítomnost neutrofilních buněk (neutrofilní segment na 11. hodině). Monocytární řada představuje > 80 % jaderných buněk dřeně. Description: Promonocytes, monocytes and one monoblast (at 5 o'clock). The presence of neutrophil cells can be rarely find (segmented neutrophil at 11 o'clock). Monocytic lineage represents > 80% nucleated bone marrow cells.
Type: bone marrow
Klíčová slova*: segmented granulocyte, monoblast, promonocyte, monocyte
AML M5b peripheral blood
One segmented neutrophil and two atypical monocytes - they have more basophilic cytoplasm and lower one has obvious and large nulceoli. / Jeden neutrofilní segment a dva atypické monocyty - mají více basofilní cytoplazma a spodní má jasná a velká jadérka. Description: One segmented neutrophil and two atypical monocytes - they have more basophilic cytoplasm and lower one has obvious and large nulceoli.
Type: peripheral blood
Klíčová slova*: segmented granulocyte, monocyte
AML M2- bone marrow 3
Infiltration of blasts medium to large of size, some with granulation; Auer rod is present in cytoplasm of second blast from the right. Some of neutrophils are with nuclear hyposegmentation and cytoplasmatic hypogranulation. Numerous naked cells. / Infiltrace blasty, střední až větší velikosti, některé s granulací, v cytoplazmě druhého blastu zprava je Auerova tyč; některé buňky neutrofilní řady vykazují známky hyposegmentace a hypogranulace. Četná holá jádra. Description: Infiltration of blasts medium to large of size, some with granulation; Auer rod is present in cytoplasm of second blast from the right. Some of neutrophils are with nuclear hyposegmentation and cytoplasmatic hypogranulation. Numerous naked cells.
Type: bone marrow
Klíčová slova*: myeloblast, Auer rod, hyposegmentation, hypogranulation
AMML Eo CHE
Staining of naftol ASC chloracetate esterase is positive in neutrophil lineage, negative in monocytic cells. In this case AML inv(16) is faintly positive reaction in abnormal eosinophils (at 5 and at 12 o'clock) - usually are eosinophils negative. / Barvení na chloracetát esterázu je pozitivní v neutrofilní řadě, negativní v monocytárních buňkách. V tomto případě AML inv(16) je slabě pozitivní reakce v abnormálních eozinofilech (na 5. a 12. hodině)- obvykle jsou eozinofily negativní. Description: Staining of naftol ASC chloracetate esterase is positive in neutrophil lineage, negative in monocytic cells. In this case AML inv(16) is faintly positive reaction in abnormal eosinophils (at 5 and at 12 o'clock) - usually are eosinophils negative.
Type: bone marrow
Klíčová slova*: neutrophil, eosinophil, monocyte
AMML Eo peripheral blod
Monocytes in peripheral blood reach to 47% (absolute number 12,7G/l) at the time of diagnosis. One segmented neutrophil at 4 o'clock. / Monocyty v periferní krvi dosahují v čase diagnózy 47% (absolutní počet 12,7G/l)- Jeden neutrofilní segment na 4. hodině. Description: Monocytes in peripheral blood reach to 47% (absolute number 12,7G/l) at the time of diagnosis. One segmented neutrophil at 4 o'clock.
Type: peripheral blood
Klíčová slova*: segmented granulocyte, monocyte
MDS RAEB II
In the centre of the picture there is a dysplastic megakaryocyte with devided nucleus, maturation caryomere is seen on the left part of it's cytoplasm. Above this megakaryocyte you can see a lymphoblast with condensed chromatin. At the right there is a hypergranular band form of neutrophil. / Ve středu obrázku je dysplastický megakaryocyt s fragmentovaným jádrem, částečně v levé části vyzrává cytoplasma v karyomer. U horního okraje obrázku je lymfoblast (prstenčitě kondenzovaný chromatin), vpravo hypergranulovaná tyčka. Description: In the centre of the picture there is a dysplastic megakaryocyte with devided nucleus, maturation caryomere is seen on the left part of it's cytoplasm. Above this megakaryocyte you can see a lymphoblast with condensed chromatin. At the right there is a hypergranular band form of neutrophil.
Type: bone marrow
Klíčová slova*: megakaryocyte
MDS RAEB II
In the left part on the picture there is immature megakaryocyte with single nucleus and withaut mature granulomer. In the right part of the picture we can see the beginning of the apoptosis of the neutrophil. In the myelocytes and metamyelocytes you can see hypergranularity. / V levé části obrázku nezralý megakaryocyt s nefragmentovaným jádrem a nevytvořeným granulomerem. V pravé části obrázku počínající apoptóza neutrofilu. V buňkách myelořady hypergranulace. Description: In the left part on the picture there is immature megakaryocyte with single nucleus and withaut mature granulomer. In the right part of the picture we can see the beginning of the apoptosis of the neutrophil. In the myelocytes and metamyelocytes you can see hypergranularity.
Type: bone marrow
Klíčová slova*: megakaryocyte, hypogranulation
CML - bone marrow
Hyperplastic bone marrow with an increase of the granulocytic line and with two peaks in the percentages of myelocytes and segmented neutrophils. / Hyperplastická kostní dřeň se zvýšením granulocytární řady s dvěma vrcholy v procentech myelocytů a neutroiflních segmentů. Description: Hyperplastic bone marrow with an increase of the granulocytic line and with two peaks in the percentages of myelocytes and segmented neutrophils.
Type: bone marrow
Klíčová slova*: myelocyte, segmented granulocyte
CML - peripheral blood
Leukocytosis, left shift in neutrophil maturation and one basophil. (at the 11 o'clock). / Leukocytóza, posun doleva a jeden bazofil (na 11. hodině). Description: Leukocytosis, left shift in neutrophil maturation and one basophil. (at the 11 o'clock).
Type: peripheral blood
Klíčová slova*: basophil
CML - peripheral blood
Myelocytes and neutrophil segments are predominant cells in peripheral blood smears. / Myelocyty a neutrofilní segmenty jsou dominujícími elementy v nátěrech periferní krve. Description: Myelocytes and neutrophil segments are predominant cells in peripheral blood smears.
Type: peripheral blood
Klíčová slova*: myelocyte, segmented granulocyte
CML - bone marrow
Granulocytic hyperplasia - some eosinophils and basophils, predominant cells are mature neutrophils and myelocytes. Smear do not shows any marked dysplastic changes but one hypo-granular pseudo-pelgeroid segmented neutrophil (underneath centre of the picture at the 5 o'clock). / Granulocytární hyperplázie - několik eozinoiflů a bazofilů, dominujícími buňkami jsou zralé neutrofily a myelocyty. Nátěr neukazuje žádné zřetelné dysplastické změny s výjimkou jednoho hypogranulárního pseudo-pelgeroidního neutrofilního segmentu (pod centrem obrázku na 5. hodině). Description: Granulocytic hyperplasia - some eosinophils and basophils, predominant cells are mature neutrophils and myelocytes. Smear do not shows any marked dysplastic changes but one hypo-granular pseudo-pelgeroid segmented neutrophil (underneath centre of the picture at the 5 o'clock).
Type: bone marrow
Klíčová slova*: myelocyte, eosinophil, basophil, segmented granulocyte, pseudo-Pelger anomaly, hypogranulation
CML - peripheral blood
Smear shows numerous myelocytes and segmented neutrophils. One basophil at the 8 o'clock. / Nátěr ukazuje četné myelocyty a neutrofilní segmenty. Jeden basofil na 8. hodině. Description: Smear shows numerous myelocytes and segmented neutrophils. One basophil at the 8 o'clock.
Type: peripheral blood
Klíčová slova*: myelocyte, basophil, segmented granulocyte
CML - peripheral blood
In the middle of the picture are myelocytes, segmented neutrophils and two rather immature eosinophils. Mature basophil is on the left. / Uprostřed obrázku jsou myelocyty, neutrofilní segmenty a dva spíše nezralé eozinofily. Zralý basofil je nalevo. Description: In the middle of the picture are myelocytes, segmented neutrophils and two rather immature eosinophils. Mature basophil is on the left.
Type: peripheral blood
Klíčová slova*: myelocyte, eosinophil, basophil, segmented granulocyte