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164 cs: Splenický lymfom z B buněk marginální zóny
en: Splenic marginal zone B cell lymphoma 		11 Monika Antošová, A. Buliková, J. Kissová 21.6.2008, 13:11 21.7.2008, 15:31 21.7.2008, 15:31 J. Kissová
139 cs: Chronická lymfatická leukémie/malobuněčný lymfom
en: Chronic lymphocytic leukaemia/small lymphocytic lymphoma 		8 Monika Antošová, A. Buliková, J. Kissová 20.4.2008, 17:13 22.6.2008, 18:49 22.6.2008, 18:49 J. Kissová
29 cs: ALL L1, ALL L2 (BFM klasifikace-morfologická)
en: ALL L1, ALL L2 (BFM morfologic classification) 		4 S. Valníček 10.11.2006, 10:47 3.12.2007, 19:04 3.12.2007, 19:04 Jan Blatný


Nalezené obrázky* (n=37)

AML without maturation- PB
There are nine myeloblasts and two lymphocytes (5 and 10 o'clock) in the picture. Comparison of the chromatin pattern in these two type of the cells confirm really fine chromatin in myeloblasts. / Na obrázku je devět myeloblastů a dva lymfocyty (na 5. a 10. hodině). Srovnání charakteru chromatinu obou typů buněk potvrzuje opravdu jemný chromatin u myeloblastů. Description: There are nine myeloblasts and two lymphocytes (5 and 10 o'clock) in the picture. Comparison of the chromatin pattern in these two type of the cells confirm really fine chromatin in myeloblasts.
Type: peripheral blood
Klíčová slova*: myeloblast, lymphocyte
AML without maturation- BM
Bone marrow is rich and infiltrated by uniform population of myeloblasts. There are only two lymphocytes (in the middle and at 6 o'clock) there; they can be distinguished by mature chromatin and markable smaller cell¨s size. One promyelocyte - large cell, ex-centric nucleus, numerous azurophilic granulation - is at the bottom of the picture (8 o'clock). / Kostní dřeň je bohatá a infiltrovaná uniformní populací myeloblastů. Jsou zde jen dva lymfocyty (uprostřed a na 6. hodině); tyto mohou být odlišeny podle zralého chromatinu a zřetelně menší velikosti buňky. Jeden promyelocyt - větší buňka, excentrické jádro, početná azurofilní granulace - je v dolní části obrázku (na 8. hodině). Description: Bone marrow is rich and infiltrated by uniform population of myeloblasts. There are only two lymphocytes (in the middle and at 6 o'clock) there; they can be distinguished by mature chromatin and markable smaller cell¨s size. One promyelocyte - large cell, ex-centric nucleus, numerous azurophilic granulation - is at the bottom of the picture (8 o'clock).
Type: bone marrow
Klíčová slova*: myeloblast, promyelocyte, lymphocyte
AML with multilineage dysplasia - PB
There are two myeloblasts here - rather large cells with round or oval nuclei, fine chromatin pattern, two to three nucleoli, moderately basophilic cytoplasm without granulation. One lymphocyte lays beside myeloblast at the left side of the picture. / Zde jsou dva myeloblasty - spíše velké buňky s kulatými až oválnými jádry, jemným vzorkem chromatinu, dvěma až třemi jadérky, středně basofilní cytoplazmou bez granulace. Jeden lymfocyt leží vedle myeloblastu na levé straně obrázku. Description: There are two myeloblasts here - rather large cells with round or oval nuclei, fine chromatin pattern, two to three nucleoli, moderately basophilic cytoplasm without granulation. One lymphocyte lays beside myeloblast at the left side of the picture.
Type: peripheral blood
Klíčová slova*: myeloblast, lymphocyte
Anaplastic large cell lymphoma - ALK negative
Two closely pressed malignant lymphoma cells with ex-centric nucleus, reticular chromatin pattern, few nucleoli and abundant pale basophilic finely vacuolized cytoplasm. / Dvě těsně přitištěné maligní lymfomové buňky s excentrickým jádrem, síťovitým vzorkem jaderného chromatinu, několika jadérky a bohatou světle bazofilní jemně vakuolizovanou cytoplazmou. Description: Two closely pressed malignant lymphoma cells with ex-centric nucleus, reticular chromatin pattern, few nucleoli and abundant pale basophilic finely vacuolized cytoplasm.
Type: bone marrow
Klíčová slova*: lymphocyte atypical
Anaplastic large cell lymphoma - ALK negative
One tumour cell in ALCL (middle right) - large cell with fine nuclear chromatin, prominent nucleolus, abundant cytoplasm which basophilia passes to eosinophilia. There are also three neutrophil myelocytes (upper one is destroyed), one lymphocyte (at 3 o'clock). The last cell in the picture is macrophage (between two myelocytes). These cells are typical component of this lymphohistiocytic variant of the lymphoma . / Jedna nádorová buňka u ALCL (ve středu vpravo) - velká buňka s jemným jaderným chromatinem, prominujícím jadérkem, bohatou cytoplazmou jejíž basofilie přechází do eozinofilie. Také jsou zde tři neutrofilní myelocyty (horní je poškozený), jeden lymfocyt (na 3. hodině). Poslední buňkou na obrázku je makrofág (mezi dvěma myelocyty). Tyto buňky jsou typickou součástí této lymfohistiocytární varianty lymfomu. Description: One tumour cell in ALCL (middle right) - large cell with fine nuclear chromatin, prominent nucleolus, abundant cytoplasm which basophilia passes to eosinophilia. There are also three neutrophil myelocytes (upper one is destroyed), one lymphocyte (at 3 o'clock). The last cell in the picture is macrophage (between two myelocytes). These cells are typical component of this lymphohistiocytic variant of the lymphoma .
Type: bone marrow
Klíčová slova*: myelocyte, macrophage, tumour cell
Anaplastic large cell lymphoma - ALK negative
Large cell with kidney-shaped nucleus with eosinophilic region in cytoplasm at lower right quadrant of the cell, while another parts of cytoplasm is basophilic. The cytoplasm is abundant. There are some blue nucleoli in the nucleus. The cell size one can estimate to 40 micrometers and more. / Velká buňka s ledvinovitým tvarem jádra s eozinofilní oblastí v cytoplazmě v dolním pravém kvadrantu buňky. Cytoplazma je bohatá. Několik modrých jadérek je v jádře. Velikost buňky může být odhadována na 40 mikrometrů a více. Description: Large cell with kidney-shaped nucleus with eosinophilic region in cytoplasm at lower right quadrant of the cell, while another parts of cytoplasm is basophilic. The cytoplasm is abundant. There are some blue nucleoli in the nucleus. The cell size one can estimate to 40 micrometers and more.
Type: bone marrow
Klíčová slova*: lymphocyte atypical
Anaplastic large cell lymphoma - ALK negative
The large cell or one can say almost giant one tumour cell in blood marrow in ALCL and ALK negative T- cell lymphoma. Kidney shape of nucleus is rather typical as also they are multiple nuclei. Cytoplasm is abundant when one compares it with immature nucleus chromatin pattern. / Velká a lze říci až obrovská nádorová buňka v kostní dření u ALCL ALK negativního T-buněčného lymfomu. Ledvinovitý tvar jádra je spíše typický podobně jako mnohočetná jadérka. Cytoplazma je bohatá při porovnání s nezralým vzhledem jaderného chromatinu. Description: The large cell or one can say almost giant one tumour cell in blood marrow in ALCL and ALK negative T- cell lymphoma. Kidney shape of nucleus is rather typical as also they are multiple nuclei. Cytoplasm is abundant when one compares it with immature nucleus chromatin pattern.
Type: bone marrow
Klíčová slova*: lymphocyte atypical
Anaplastic large cell lymphoma - ALK negative
Another example of anaplastic large lymphoma cell. Here is ex-centric, horse-shoe-shaped nucleus. Eosinophilic area of cytoplasm is at 3 o'clock. Nuclear chromatin is fine, nucleus contains several prominent nucleoli. There is bi-lobar late normoblast with internuclear bride at 3 o'clock. / Jiný příklad buňky anaplastického velkobuněčného lymfomu. Zde je jádro excentrické, podkovovitého tvaru. Eozinofilní oblast cytoplazmy je na 3 hodině. Jaderný chromatin je jemný, jádro obsahuje několik prominujících jadérek. Na 3. hodině je pozdní normoblast, bilobární s jaderným můstkem. Description: Another example of anaplastic large lymphoma cell. Here is ex-centric, horse-shoe-shaped nucleus. Eosinophilic area of cytoplasm is at 3 o'clock. Nuclear chromatin is fine, nucleus contains several prominent nucleoli. There is bi-lobar late normoblast with internuclear bride at 3 o'clock.
Type: bone marrow
Klíčová slova*: lymphocyte atypical
Anaplastic large cell lymphoma - ALK negative
Two lymphoma cells are in the picture. One of them is large with almost round nucleus with fine chromatin and prominent nucleoli, abundant basophilic cytoplasm converts to more basophilic at the right perinuclear area. Another lymphoma cell is smaller (at 8 o'clock) with ex-centric nucleus. It contains fine chromatin and 2 to 3 small nucleoli. Other cells of the picture belong to neutrophil lineage including one mitosis (at the right from the centre). There is one monocyte above at large lymphoma cell. / Na obrázku jsou dvě lymfomové buňky. Jedna z nich je velká s téměř kulatým jádrem, s jemným jaderným chromatinem a prominujícími jadérky, bohatá bazofilní cytoplazma se mění ve více eozinofilní v pravé perinukleární oblasti. Jiná lymfomová buňka (na 8. hodině) je menší s excentrickým jádrem. Obsahuje jemný jaderný chromatin a 2-3 malá jadérka. Další buňky na obrázku patří neutrofilní řadě včetně jedné mitózy (napravo od středu). Jeden monocyt je nad velkou lymfomovou buňkou. Description: Two lymphoma cells are in the picture. One of them is large with almost round nucleus with fine chromatin and prominent nucleoli, abundant basophilic cytoplasm converts to more basophilic at the right perinuclear area. Another lymphoma cell is smaller (at 8 o'clock) with ex-centric nucleus. It contains fine chromatin and 2 to 3 small nucleoli. Other cells of the picture belong to neutrophil lineage including one mitosis (at the right from the centre). There is one monocyte above at large lymphoma cell.
Type: bone marrow
Klíčová slova*: monocyte, lymphocyte atypical
Splenic marginal zone B- cell lymphoma
Four lymphoma cells. The cell at upper left has cleft nucleus or one can say that it is binuclear; chromatin of this cell shows more coarse clumping (more immature) and there is prominent nucleolus at the upper part of the nucleus. / Čtyři lymfomové buňky. Buňka nahoře vlevo má štěpené jádro nebo lze říci, že je binukleární; chromatin této buňky ukazuje více chomáčkovité shlukování (více nezralý) a v horní části jádra je prominující jadérko. Description: Four lymphoma cells. The cell at upper left has cleft nucleus or one can say that it is binuclear; chromatin of this cell shows more coarse clumping (more immature) and there is prominent nucleolus at the upper part of the nucleus.
Type: bone marrow
Klíčová slova*: lymphocyte atypical
Splenic marginal zone B- cell lymphoma
Three lymphoma cells with round or oval nuclei and small nucleoli. Cytoplasmic blebs are evident especially in the cell at the upper right. / Tři lymfomové buňky s kulatými nebo oválnými jádry a malými jadérky. Cytoplazmatické "blebs" jsou zřejmé zejména v buňce nahoře vpravo. Description: Three lymphoma cells with round or oval nuclei and small nucleoli. Cytoplasmic blebs are evident especially in the cell at the upper right.
Type: bone marrow
Klíčová slova*: lymphocyte, lymphocyte atypical
Splenic marginal zone B- cell lymphoma
In bone marrow smears usually villous lymphocytes are less evident than in peripheral blood smears especially when they are made from fresh blood. The picture shows a group of medium size lymphocytes with blue cytoplasm, but cytoplasmic projections are less pronounced. / V kostní dřeni jsou obvykle vilózní lymfocyty méně zřetelné než v nátěrech periferní krve, zvláště jsou-li zhotoveny z čerstvé krve. Obrázek ukazuje skupinu středně velkých lymfocytů s modrou cytoplazmou, ale cytoplazmatické výběžky jsou méně zjevné. Description: In bone marrow smears usually villous lymphocytes are less evident than in peripheral blood smears especially when they are made from fresh blood. The picture shows a group of medium size lymphocytes with blue cytoplasm, but cytoplasmic projections are less pronounced.
Type: bone marrow
Klíčová slova*: lymphocyte atypical
Splenic marginal zone B-cell lymphoma
The most of lymphocytes in the picture belong to lymphoma cells. But that one at 5 o'clock is large granular lymphocyte (LGL) - it means NK cell or mature T lymphocyte. Also lymphocyte at 4 o'clock does not seems to be lymphoma cell. It can be reactive lymphocyte according to pale cytoplasm with more basophilic rim. / Většina lymfocytů na obrázku patří k lymfomovým buňkám. Ale ta na 5. hodině je velký granulovaný lymfocyt (LGL) - to znamená NK buňka či zralý T lymfocyt. Také lymfocyt na 4. hodině se nezdá být buňkou lymfomovou. Může jít o reaktivní lymfocyt podle světlé cytoplazmy s více bazofilním okrajem. Description: The most of lymphocytes in the picture belong to lymphoma cells. But that one at 5 o'clock is large granular lymphocyte (LGL) - it means NK cell or mature T lymphocyte. Also lymphocyte at 4 o'clock does not seems to be lymphoma cell. It can be reactive lymphocyte according to pale cytoplasm with more basophilic rim.
Type: bone marrow
Klíčová slova*: lymphocyte reactive, large granular lymphocyte, lymphocyte atypical
Splenic marginal zone B- cell lymphoma
Massive bone marrow infiltration by lymphoma cells. Their nuclei have condensed chromatin, about half of the cells express small nucleolus. Only very few of the cells are more immature ones (cell in the middle at 3 o'clock) with more immature chromatin and high N/C ratio. Cytoplasm of the most tumour cells have some projections. / Masivní infiltrace kostní dřeně lymfomovými buňkami. Jejich jádra mají kondenzovaný chromatin, asi polovina buněk exprimuje malé jadérko. Jen velmi málo buněk je méně zralých (buňka uprostěd na 3. hodině) s více nezralým chromatinem a vysokým N/C poměrem. Cytoplazma většiny nádorových buněk má nějaké výběžky. Description: Massive bone marrow infiltration by lymphoma cells. Their nuclei have condensed chromatin, about half of the cells express small nucleolus. Only very few of the cells are more immature ones (cell in the middle at 3 o'clock) with more immature chromatin and high N/C ratio. Cytoplasm of the most tumour cells have some projections.
Type: bone marrow
Klíčová slova*: lymphocyte atypical
Splenic marginal zone B- cell lymphoma
Numerous villous lymphocytes in bone marrow smear. Some show nucleoli in their nuclei. There is segmented neutrophil underneath the centre of the picture and one large granular lymphocyte at 5 o' clock. / Početné vilózní lymfocyty v nátěru kostní dřeně. Některé mají jadérka v jádrech. Jeden neutrofilní segment je pod středem obrázku a velký granulovaný lymfocyt na 5. hodině. Description: Numerous villous lymphocytes in bone marrow smear. Some show nucleoli in their nuclei. There is segmented neutrophil underneath the centre of the picture and one large granular lymphocyte at 5 o' clock.
Type: bone marrow
Klíčová slova*: large granular lymphocyte, lymphocyte atypical
Splenic marginal zone B- cell lymphoma
Middle size cells with rather abundant cytoplasm with villi. When one compare there cells with tumour cells of hairy cell leukaemia, they have more basophilic cytoplasm and cytoplasmic projections are more thick and less numerous. / Středně velké buňky se spíše bohatou cytoplazmou s vlásky. Při srovnání těchto buněk s nádorovými buňkami vlasatobuněčné leukémie mají tyto více bazofilní cytoplazmu a cytoplazmatické projekce jsou silnější a méně početné. Description: Middle size cells with rather abundant cytoplasm with villi. When one compare there cells with tumour cells of hairy cell leukaemia, they have more basophilic cytoplasm and cytoplasmic projections are more thick and less numerous.
Type: peripheral blood
Klíčová slova*: lymphocyte atypical
Splenic marginal zone B- cell lymphoma
"Villous lymphocyte" in detail. Rather abundant basophilic cytoplasm with few projections at two opposite sides of the cell. One poorly seen nucleolus is at the lower part of nucleus. Cytoplasm contains some vacuoles and one cytoplasmic inclusion. / "Vilózní lymfocyt" v detailu. Spíše bohatší bazofilní cytoplazma s několika projekcemi na dvou protilehlých stranách buňky. Jedno špatně viditelné jadérko v dolní části jádra. Cytoplazma obsahuje několik vakuol a jednu cytoplazmatickou inkluzi. Description: "Villous lymphocyte" in detail. Rather abundant basophilic cytoplasm with few projections at two opposite sides of the cell. One poorly seen nucleolus is at the lower part of nucleus. Cytoplasm contains some vacuoles and one cytoplasmic inclusion.
Type: peripheral blood
Klíčová slova*: lymphocyte atypical
Splenic marginal zone B-cell lymphoma
In this thinner part of the smear lymphoma cells are better seen in details. Cells have moderately condensed chromatin, nucleoli are rather inconspicuous in this case. Cytoplasm is basophilic with clear projections (two cells at the lower left). / V této tenčí části nátěru jsou lymfomové buňky lépe viditelné v detailech. Buňky mají středně kondenzovaný chromatin, jadérka jsou v tomto případě spíše nezřetelná. Cytoplazma je bazofilní s jasnými projekcemi (dvě buňky vlevo dole). Description: In this thinner part of the smear lymphoma cells are better seen in details. Cells have moderately condensed chromatin, nucleoli are rather inconspicuous in this case. Cytoplasm is basophilic with clear projections (two cells at the lower left).
Type: peripheral blood
Klíčová slova*: lymphocyte atypical
Splenic marginal zone B- cell lymphoma
Another example of "villous lymphocytes" in peripheral blood smear (without EDTA). Cytoplasm of the lymphoma cells is quite basophilic. One segmented eosinophil at the middle left. / Jiný příklad "vilózních lymfocytů" v nátěru periferní krve (bez EDTA). Cytoplazma lymfomových buněk je docela bazofilní. Jeden segmentovaný eozinofil vlevo uprostřed. Description: Another example of "villous lymphocytes" in peripheral blood smear (without EDTA). Cytoplasm of the lymphoma cells is quite basophilic. One segmented eosinophil at the middle left.
Type: peripheral blood
Klíčová slova*: lymphocyte atypical
Splenic marginal zone B- cell lymphoma
Lymphoma cell with short polar villi in peripheral blood smear (fresh capillary blood smear). Cells are larger than normal small lymphocyte with round to oval nucleus. There are not seen clear nucleoli here. / Lymfomové buňky s krátkými polárními výběžky v nátěru periferní krve (nátěr čerstvé kapilární krve). Buňky jsou větší než normální malý lymfocyt, s kulatým až oválným jádrem. Jasná jadérka zde nejsou patrná. Description: Lymphoma cell with short polar villi in peripheral blood smear (fresh capillary blood smear). Cells are larger than normal small lymphocyte with round to oval nucleus. There are not seen clear nucleoli here.
Type: peripheral blood
Klíčová slova*: lymphocyte atypical
Hairy cell leukaemia- PB
Some hairy cell can remind monocyte, but cytoplasm is pale blue in this case instead of grey in monocytes. On the other hand monocytopenia is typical sign in hairy cell leukemia. There is normal lymphocyte at upper right. / Některé vlasaté buňky mohou přípomínat monocyty, ale cytoplazma je v tomto případě světle modrá na rozdíl od šedé u monocytů. Naopak monocytopenie je typickou známkou u vlasatobuněčné leukémie. Nahoře vpravo je normální lymfocyt. Description: Some hairy cell can remind monocyte, but cytoplasm is pale blue in this case instead of grey in monocytes. On the other hand monocytopenia is typical sign in hairy cell leukemia. There is normal lymphocyte at upper right.
Type: peripheral blood
Klíčová slova*: hairy cell
Hairy cell leukaemia- BM
Chromatin of nucleus is less condensed to compare normal lymphocyte in hairy cell. Abundant cytoplasm contains few discrete vacuoles and protrudes circumferential in "hairy" projections / Jaderný chromatin "vlasatých" buněk je méně kondenzován ve srování s normálním lymfocytem. Objemná cytoplazma obsahuje několik drobných vakuol a vybíhá do "vlasatých" výběžků po obvodu buňky. Description: Chromatin of nucleus is less condensed to compare normal lymphocyte in hairy cell. Abundant cytoplasm contains few discrete vacuoles and protrudes circumferential in "hairy" projections
Type: bone marrow
Klíčová slova*: hairy cell, lymphocyte atypical, vacuolisation
Hairy cell leukaemia- BM
Smears of bone marrow aspirate use to be pure because aspiration is usually difficult or even impossible. Tumour cells can represent only minority cell population. Cells are the most often medium-size, but larger then normal lymphocyte. They have abundant weakly basophilic cytoplasm with irregular cytoplasmic margins. The cell at upper right contains few cytoplasmic inclusions. / Nátěry z aspirační biospie jsou obvykle chudé protože aspirace je většinou obtížná nebo dokonce nemožná. Nádorové buňky mohou představovat jen minoritní buněčnou populaci. Buňky jsou nejčastěji střední velikosti, ale větší než normální lymfocyt. Mají objemnou slabě basofilní cytoplazmu s nepravidelnými cytoplazmatickými okraji. Buňka vpravo nahoře obsahuje několik cytoplazmatických inkluzí. Description: Smears of bone marrow aspirate use to be pure because aspiration is usually difficult or even impossible. Tumour cells can represent only minority cell population. Cells are the most often medium-size, but larger then normal lymphocyte. They have abundant weakly basophilic cytoplasm with irregular cytoplasmic margins. The cell at upper right contains few cytoplasmic inclusions.
Type: bone marrow
Klíčová slova*: cytoplasmic inclusion, hairy cell
Hairy cell leukaemia- BM
In this case of hairy cell leukemia smears shows unusually large tumour cells (usually medium-size), with irregular nucleus shape and/or cleft . Chromatin of the nucleus is spongy, less clumped than that of a normal lymphocyte. / V tomto případě vlasatobuněčné leukémie nátěry ukazují neobvykle velké nádorové buňky (obvykle střední velikosti). Jaderný chromatin je pórovitý, méně kondenzovaný nežli tomu je u normálního lymfocytu. Description: In this case of hairy cell leukemia smears shows unusually large tumour cells (usually medium-size), with irregular nucleus shape and/or cleft . Chromatin of the nucleus is spongy, less clumped than that of a normal lymphocyte.
Type: bone marrow
Klíčová slova*: hairy cell
CML accelerated phase - PB
Leucocytosis, left shift. Two blasts at the right side (at 3. o´clock). basophil on the left. Normoblast in the centre, lymphocyte at the right side up. / Leukocytóza, posun doleva. Dva blasty vpravo ( na 3. hodině), bazofil vlevo. Normoblast uprostřed, lymfocyt vpravo nahoře. Description: Leucocytosis, left shift. Two blasts at the right side (at 3. o´clock). basophil on the left. Normoblast in the centre, lymphocyte at the right side up.
Type: peripheral blood
Klíčová slova*: myeloblast, myelocyte, metamyelocyte, basophil, lymphocyte, normoblast
AML- peripheral blood
The II-nd type of myeloblast in AML; there are few fine azurophilic granules in cytoplasm at the right side of the nucleus. It contains three apparent nucleoli. Underneath of this cell is mature lymphocyte. / Myeloblast II. typu u AML, vpravo od jádra je v cytoplazmě několik azurofilních granulí. Jádro obsahuje tří zřetelná jadérka. Pod touto buňkou je zralý lymfocyt. Description: The II-nd type of myeloblast in AML; there are few fine azurophilic granules in cytoplasm at the right side of the nucleus. It contains three apparent nucleoli. Underneath of this cell is mature lymphocyte.
Type: peripheral blood
Klíčová slova*: myeloblast, lymphocyte
AML- peripheral blood
Peripheral blood smear in AML shows II-nd type myeloblast with Auer rod at the right and lymphocyte at the left. / Nátěr periferní krve u AML ukazuje myeloblast II. typu s Auerovou tyčí vpravo a lymfocyt vlevo. Description: Peripheral blood smear in AML shows II-nd type myeloblast with Auer rod at the right and lymphocyte at the left.
Type: peripheral blood
Klíčová slova*: myeloblast, lymphocyte, Auer rod
Chronic lymphocytic leukaemia/small lymphocytis lymphoma
Bone marrow is hypercellular with infiltration by uniform population of mature, small lymphocytes (smaller magnification). They represent 97,2 % of all nucleated cells in the smear. / Kostní dřen je hypercelulární s infiltrací uniformní populací zralých, malých lymfocytů (menší zvětšení). Tyto představují 97,2% jaderných buněk nátěru. Description: Bone marrow is hypercellular with infiltration by uniform population of mature, small lymphocytes (smaller magnification). They represent 97,2 % of all nucleated cells in the smear.
Type: bone marrow
Klíčová slova*: lymphocyte
Chronic lymphocytic leukaemia/small lymphocytis lymphoma
Peripheral blood smear shows small or medium size (upper left) lymphocytes with oval or round nuclei and clumped chromatin, scanty cytoplasm and a regular cellular outline. Cleft nucleus (underneath the centre) is rare in this diagnose. Some prolymphocytes can occur (at the centre), they have prominent nucleolus and more abundant cytoplasm (4% of leukocytes in this case). / Nátěr periferní krve ukazuje malé nebo středně velké (vlevo nahoře) lymfocyty s oválnými či kulatými jádry a chomáčkovitým chromatinem, chudou cytoplazmou a pravidelnou zevní linií buňky. Rozštěpené jádro (pod centrem) je u této diagnózy vzácné. Může se objevit pár prolymfocytů (v centru), ty mají prominující jadérka a více objemnou cytoplazmu (v tomto případě 4% leukocytů). Description: Peripheral blood smear shows small or medium size (upper left) lymphocytes with oval or round nuclei and clumped chromatin, scanty cytoplasm and a regular cellular outline. Cleft nucleus (underneath the centre) is rare in this diagnose. Some prolymphocytes can occur (at the centre), they have prominent nucleolus and more abundant cytoplasm (4% of leukocytes in this case).
Type: peripheral blood
Klíčová slova*: prolymphocyte, lymphocyte
Chronická lymfatická leukémie/malobuněčný lymfom
Small mature lymphocytes with clear cytoplasm, which contains few vacuoles. There is one prolymphocyte at the middle right. Few typical broken cells. / Malé zralé lymfocyty s jasnou cytoplazmou, která obsahuje několik vakuol. Jeden prolymfocyt je vpravo ve středu. Několik typických rozbitých buněk. Description: Small mature lymphocytes with clear cytoplasm, which contains few vacuoles. There is one prolymphocyte at the middle right. Few typical broken cells.
Type: bone marrow
Klíčová slova*: prolymphocyte, lymphocyte, nuclear shadows
Chronická lymfatická leukémie/malobuněčný lymfom
Three small and one middle size lymfocytes. There is one prolymphocyte in the middle - it is larger cell with more abundant cytoplasm all around the nucleus, it has prominent nucleolus, chromatin is rather mature. Few nuclear shades. / Tři malé a jeden středně velký lymfocyt. Uprostřed je jeden prolymfocyt - je to větší buňky s objemnější cytoplazmou okolo celého jádra, má prominující jadérko, chromatin je spíše zralý. Několik jaderných stínů. Description: Three small and one middle size lymfocytes. There is one prolymphocyte in the middle - it is larger cell with more abundant cytoplasm all around the nucleus, it has prominent nucleolus, chromatin is rather mature. Few nuclear shades.
Type: bone marrow
Klíčová slova*: prolymphocyte, lymphocyte, nuclear shadows
Chronic lymphocytic leukaemia/small lymphocytis lymphoma
Some lymphocytes can be larger than small especially in advanced cases (above the centre). Oval or round nuclei can have small central depression at one side occasionally (cell to the left from the centre), there is more abundant cytoplasm here. / Některé lymfocyty mohou být větší nežli malé zejména u pokročilých případů (nad centrem). Oválná či kulatá jádra mohou mít občas malou centrální prohlubeň na jedné straně (buňka doleva od centra), zde je také více objemná cytoplazma. Description: Some lymphocytes can be larger than small especially in advanced cases (above the centre). Oval or round nuclei can have small central depression at one side occasionally (cell to the left from the centre), there is more abundant cytoplasm here.
Type: bone marrow
Klíčová slova*: lymphocyte
Chronická lymfatická leukémie/malobuněčný lymfom
Numerous small lymphocytes and one segmented neutrophil (at 6 o'clock). Broken cell are typically seen in the smears. They are characteristic but nor pathognomic since they are occasionally seen in a variety other conditions. But only in CLL they are known as "Gumprecht's shades". / Početné malé lymfocyty a jeden neutrofilní segment (na 6. hodině). Rozbité buňky jsou typicky patrné v nátěrech. Jsou charakteristické ale ne patognomické, protože je možné je občas najít i u různých jiných stavů. Avšak jen u CLL jsou známy jako "Gumprechtovy stíny". Description: Numerous small lymphocytes and one segmented neutrophil (at 6 o'clock). Broken cell are typically seen in the smears. They are characteristic but nor pathognomic since they are occasionally seen in a variety other conditions. But only in CLL they are known as "Gumprecht's shades".
Type: bone marrow
Klíčová slova*: segmented granulocyte, lymphocyte, nuclear shadows
Chronická lymfatická leukémie/malobuněčný lymfom
Small lymphocytes with mature nuclear chromatin, invisible nucleoli and scanty cytoplasm without granulation represent predominant population in bone marrow. The typical feature are also nuclear shadows. / Malé lymfocyty se zralým jaderným chromatinem, nezřetelnými jadérky a chudou cytoplazmou bez granulace představují hlavní populaci kostní dřeně. Typickým rysem jsou také jaderné stíny. Description: Small lymphocytes with mature nuclear chromatin, invisible nucleoli and scanty cytoplasm without granulation represent predominant population in bone marrow. The typical feature are also nuclear shadows.
Type: bone marrow
Klíčová slova*: lymphocyte, nuclear shadows
Chronic lymphocytic leukaemia/small lymphocytis lymphoma
Small lymphocytes in CLL use to have round or oval nucleus in excentric position in the cell. Nuclear chromatin is mature, nucleoli are indistinct or absent. Cytoplasm is pure, weakly basophilic, agranular, rarely with some vacuoles (in the middle). Broken cells or smudge cells are characteristic. / Malé lymfocyty u CLL obvykle mají kulaté či ovální jádro excentricky uložené v buňce. Jaderný chromatin je zralý, jadérka jsou nezřetelná nebo nepřítomna. Cytoplazma je chudá, slabě basofilní, agranulární, vzácně s několika vakuolami (uprostřed). Rozbité buňky nebo buňky rozmazané jsou charakteristické. Description: Small lymphocytes in CLL use to have round or oval nucleus in excentric position in the cell. Nuclear chromatin is mature, nucleoli are indistinct or absent. Cytoplasm is pure, weakly basophilic, agranular, rarely with some vacuoles (in the middle). Broken cells or smudge cells are characteristic.
Type: bone marrow
Klíčová slova*: lymphocyte, nuclear shadows
AML M5a - BE
Strong positivity of BE in all monoblasts. On the right side of the picture, there is a lymphocyte nearby the blast with dot like BE-positivity (T-lymphocyte). / Zřetelná pozitivita butyrátesterázy ve všech monoblastech, v lymfocytu vpravo u blastu sytá ložiskově lokalizovaná pozitivita T lymfocytu. Description: Strong positivity of BE in all monoblasts. On the right side of the picture, there is a lymphocyte nearby the blast with dot like BE-positivity (T-lymphocyte).
Type: bone marrow
Klíčová slova*: lymphocyte, monoblast, cytochemical stain, butyrate esterase
APL- peripheral blood 6
Pseudo Chediak-Higashi granule in hypergranulated promyelocyte. Two mature lymphocytes with short polar villi, but along the spread (artificial). / Pseudo Chediak- Higashiho granula u hypergranulovaného promyelocytu. Dva zralé lymfocyty s krátkými "vlásky" na pólech buňky, ale ve směru nátěru (arteficiálně). Description: Pseudo Chediak-Higashi granule in hypergranulated promyelocyte. Two mature lymphocytes with short polar villi, but along the spread (artificial).
Type: peripheral blood
Klíčová slova*: promyelocyte, lymphocyte, hypergranulation