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173 cs: AML s multilineární dysplázií
en: AML with multilineage dysplasia 		12 A. Buliková, J. Kissová 22.7.2008, 7:19 16.10.2008, 23:08 16.10.2008, 23:08 J. Kissová
46 cs: MDS RAEB II
en: MDS RAEB II 		10 A. Kubíková 13.12.2006, 9:55 3.12.2007, 19:41 3.12.2007, 19:41 Jan Blatný


Nalezené obrázky* (n=13)

AML with multilineage dysplasia - PB
Two myeloblasts at this next picture document that even in normal leukocyte count (5,0 G/l) circulating myeloblasts represent dominant population in patient's peripheral blood smears. Group of trombocytes (at the left from upper myeloblast) shows marked anizocytosis. / Dva myeloblasty na tomto dalším obrázku prokazují, že dokonce u normálního počtu leukocytů (5,0 G/l) cirkulující myeloblasty představují dominující populaci v nátěrech periferní krve pacienta. Skupina trombocytů (doleva od horního myeloblastu) ukazuje zřetelnou anizocytózu. Description: Two myeloblasts at this next picture document that even in normal leukocyte count (5,0 G/l) circulating myeloblasts represent dominant population in patient's peripheral blood smears. Group of trombocytes (at the left from upper myeloblast) shows marked anizocytosis.
Type: peripheral blood
Klíčová slova*: myeloblast, thrombocyte, anisocytosis
AML with multilineage dysplasia - PB
There are two myeloblasts here - rather large cells with round or oval nuclei, fine chromatin pattern, two to three nucleoli, moderately basophilic cytoplasm without granulation. One lymphocyte lays beside myeloblast at the left side of the picture. / Zde jsou dva myeloblasty - spíše velké buňky s kulatými až oválnými jádry, jemným vzorkem chromatinu, dvěma až třemi jadérky, středně basofilní cytoplazmou bez granulace. Jeden lymfocyt leží vedle myeloblastu na levé straně obrázku. Description: There are two myeloblasts here - rather large cells with round or oval nuclei, fine chromatin pattern, two to three nucleoli, moderately basophilic cytoplasm without granulation. One lymphocyte lays beside myeloblast at the left side of the picture.
Type: peripheral blood
Klíčová slova*: myeloblast, lymphocyte
AML with multilineage dysplasia - PB
Peripheral blood smears show 27% of myeloblasts (upper right) but also some other cells of granulocytic lineage - there is myelocyte at the lower left. / Nátěr periferní krve ukazuje 27% myeloblastů (nahoře vpravo), ale také jiné buňky granulocytární řady - vlevo dole je myelocyt. Description: Peripheral blood smears show 27% of myeloblasts (upper right) but also some other cells of granulocytic lineage - there is myelocyte at the lower left.
Type: peripheral blood
Klíčová slova*: myeloblast, myelocyte
AML with multilineage dysplasia - BM
Numerous myeloblast and erythroid cells are in the picture. There are some micro-forms of megakaryocytes (from 2 bi-nuclear to 4 unilobular) at the lower part of it. All of the signs in megakaryocytes signify dysplastic changes. / Na obrázku jsou početné myeloblasty a buňky erytroidní řady. V jeho dolní části je pár mikro-forem megakaryocytů (od dvou dvoujaderných do čtyř jednojaderných). Všechny tyto známky v megakaryocytech znamenají změny dysplastické. Description: Numerous myeloblast and erythroid cells are in the picture. There are some micro-forms of megakaryocytes (from 2 bi-nuclear to 4 unilobular) at the lower part of it. All of the signs in megakaryocytes signify dysplastic changes.
Type: bone marrow
Klíčová slova*: myeloblast, micromegakaryocyte
AML with multilineage dysplasia - BM
The myeloblasts are the most frequent cells of the picture, some of them are in mitosis. In erythroid lineage are megaloblastoid features - markedly expressed in two cells at 4-5 o'clock. Hypogranulation is in neutrophils. / Myeloblasty jsou nejčastějšími buňkami obrázku, některé z nich jsou v mitóze. V erytroidní řadě jsou megaloblastoidní rysy - zřetelně vyjádřeny ve dvou buňkách na 4-5. hodině. Hypogranulace je v neutrofilech. Description: The myeloblasts are the most frequent cells of the picture, some of them are in mitosis. In erythroid lineage are megaloblastoid features - markedly expressed in two cells at 4-5 o'clock. Hypogranulation is in neutrophils.
Type: bone marrow
Klíčová slova*: myeloblast, hypogranulation, megaloblastic haematopoiesis
AML with multilineage dysplasia - BM
Numerous myeloblast and cells of erythroid lineage (almost 50%) are dominant populations of the cells of the bone marrow smear. The cells of erythroid series show dysplastic features - multilobularity, non-round nucleus shape (at 11o'clock), megaloblastoid features (at 9 o'clock) and failure of cytoplasm hemoglobinization (at 3 o'clock). / Početné myeloblasty a buňky erytroidní linie (téměř 50%) jsou dominujícími populacemi buněk v nátěru kostní dřeně. Buňky erytroidní řady vykazují dysplastické rysy - multilobularitu, zneokrouhlený tvar jádra (na 11. hodině), megaloblastoidní rysy (na 9. hodině) a poruchu hemoglobinizace cytoplazmy (na 3. hodině). Description: Numerous myeloblast and cells of erythroid lineage (almost 50%) are dominant populations of the cells of the bone marrow smear. The cells of erythroid series show dysplastic features - multilobularity, non-round nucleus shape (at 11o'clock), megaloblastoid features (at 9 o'clock) and failure of cytoplasm hemoglobinization (at 3 o'clock).
Type: bone marrow
Klíčová slova*: myeloblast, megaloblastic haematopoiesis
AML with multilineage dysplasia - BM
Three myeloblast and six erythroid cells (and one naked nucleus) are in the picture. Two immature erythroid cells with abundant basophilic cytoplasm are megalobasts. At the lower left is one more cell probably of granulocytic lineage; it has a few cytoplasmic a one nuclear inclusions of not clear origin - some of them can be digestive ones after haemophagocytosis (one at 6 o'clock in the cell). / Na obrázku jsou tři myeloblasty a šest buněk erytropoezy (a jedno holé jádro). Dvě nezralé erytroidní buňky s bohatou bazofilní cytoplazmou jsou megaloblasty. Nalevo dole je jedna buňka pravděpodobně granulocytární řady; má pár cytoplazmatických a jednu jadernou inkluzi nejasného původu - některé z nich mohou být ztrávené po hemofagocytóze (jedna na 5. hodině v buňce). Description: Three myeloblast and six erythroid cells (and one naked nucleus) are in the picture. Two immature erythroid cells with abundant basophilic cytoplasm are megalobasts. At the lower left is one more cell probably of granulocytic lineage; it has a few cytoplasmic a one nuclear inclusions of not clear origin - some of them can be digestive ones after haemophagocytosis (one at 6 o'clock in the cell).
Type: bone marrow
Klíčová slova*: myeloblast, megaloblast, haemophagocytosis
AML with multilineage dysplasia - BM
Immature cells, some of them are destroyed. Bi-lobar and megaloblastoid late erythroblast is at the right from the centre. Two micro-forms of megakaryocytes are underneath the picture's centre. / Nezralé buňky, některé z nich jsou poškozené. Bilobární a megaloblastoidní pozdní erytroblast je napravo od centra. Dvě mikroformy megakaryocytů jsou pod centrem obrázku. Description: Immature cells, some of them are destroyed. Bi-lobar and megaloblastoid late erythroblast is at the right from the centre. Two micro-forms of megakaryocytes are underneath the picture's centre.
Type: bone marrow
Klíčová slova*: megakaryocyte, megaloblast
AML with multilineage dysplasia - BM
There are three myeloblasts in the picture, one of them underneath the centre with cleft nucleus. Three immature cells of erythroid lineage (proerythroblast and two more or less mature early normoblasts) belong to cells localized around the picture's centre. At 5 o'clock lays one dysplastic cell of perhaps granulocytic or may be monocytic lineage; it has band-like but really immature nucleus with fine chromatin and clear nucleoli and immature cytoplasm without granulation. Another almost bizarre cell is in the centre, it the most probably belongs in granulocytic series, it has moderately mature nucleus, basophilic cytoplasm almost without granulation but with one digested late normoblast. / Na obrázku jsou tři myeloblasty, jeden z nich pod centrem se štěpeným jádrem. Tři nezralé buňky erytroidní linie (proerytroblast a dva méně či více zralé časné normoblasty patří k buňkám umístěným okolo středu obrázku. Na 5. hodině leží dysplastická buňka granulocytární nebo možná monocytární řady; má tyčkovité ale opravdu nezralé jádro s jemným chromatinem a jasnými jadérky a nezralou cytoplazmu bez granulace. Jiná téměř bizarní buňka je ve středu, nejpravděpodobněji patří ke granulocytární řadě, má středně zralé jádro, basofilní cytoplazmu téměř bez granulace ale s jedním pohlceným pozdním normoblastem. Description: There are three myeloblasts in the picture, one of them underneath the centre with cleft nucleus. Three immature cells of erythroid lineage (proerythroblast and two more or less mature early normoblasts) belong to cells localized around the picture's centre. At 5 o'clock lays one dysplastic cell of perhaps granulocytic or may be monocytic lineage; it has band-like but really immature nucleus with fine chromatin and clear nucleoli and immature cytoplasm without granulation. Another almost bizarre cell is in the centre, it the most probably belongs in granulocytic series, it has moderately mature nucleus, basophilic cytoplasm almost without granulation but with one digested late normoblast.
Type: bone marrow
Klíčová slova*: myeloblast, proerythroblast, basophilic normoblast, haemophagocytosis
AML with multilineage dysplasia - BM
Three myeloblasts are in the lower left; one of them (underneath eosinophilic myelocyte) has some azurophilic granulation, cytoplasmic protrusions and cleft nucleus. Erythroid lineage shows dysplastic features - nuclear lobulisation, karyorhexis and poor hemoglobinization of cytoplasm. / Tři myeloblasty jsou vlevo dole, jeden z nich (pod eozinofilním myelocytem) má nějakou azurofilní granulace, cytoplazmatické výběžky a rozštěpené jádro. Erytroidní linie vykazuje dysplastické rysy - lobulizaci jádra, karyorhexi a špatnou hemoglobinizaci cytoplazmy. Description: Three myeloblasts are in the lower left; one of them (underneath eosinophilic myelocyte) has some azurophilic granulation, cytoplasmic protrusions and cleft nucleus. Erythroid lineage shows dysplastic features - nuclear lobulisation, karyorhexis and poor hemoglobinization of cytoplasm.
Type: bone marrow
Klíčová slova*: myeloblast, eosinophil
AML with multilineage dysplasia - BM
There are seven myeloblasts underneath the centre of the picture and three proerythroblasts at the upper left. Between these two groups of the cells lies one agranular band and one red mitosis. Two early polychromatophil red cells precursors (upper left) have megaloblastoid nuclear pattern and they are bilobated. Three late polychromatophil normoblasts (to the left and down from the centre) have pycnotic nuclei. / Pod centrem obrázku je sedm myeloblastů a tři proerytroblasty jsou vlevo nahoře. Mezi těmito dvěma skupinami buněk leží jedna agranulární tyčka a jedna červená mitóza. Dva časné polychromatofilní prekurzory erytrocytů mají megaloblastoidní vzhled jádra a jsou bilobární. Tři pozdní polychromatofilní normoblasty (doleva a dolu z centra) mají pyknotická jádra. Description: There are seven myeloblasts underneath the centre of the picture and three proerythroblasts at the upper left. Between these two groups of the cells lies one agranular band and one red mitosis. Two early polychromatophil red cells precursors (upper left) have megaloblastoid nuclear pattern and they are bilobated. Three late polychromatophil normoblasts (to the left and down from the centre) have pycnotic nuclei.
Type: bone marrow
Klíčová slova*: myeloblast, proerythroblast, polychromatophilic normoblast, megaloblastic haematopoiesis
AML with multilineage dysplasia - BM
Myeloblasts represent about 30% of all nucleated bone marrow cells. There is also erythroid hyperplasia here - almost 50% in bone marrow cells differential count. Cells of erythroid lineage show dysplastic features - megaloblastic nuclei, bilnuclear cells or nuclear lobulisation, internuclear bridges, poorly hemoglobinised cytoplasm. These dysplastic features are presented in more than 50% of erythroid cells. / Myeloblasty představují asi 30% ze všech jaderných buněk dřeně. Je zde taktéž erytroidní hyperplázie - téměř 50% v diferenciálním rozpočtu buněk kostní dřeně. Buňky erytroidní řady ukazují dysplastické rysy - megaloblastoidní jádra, binukleární buňky nebo jadernou lobulizaci, mezijaderné můstky, špatně hemoglobinizovanou cytoplazmu. Tyto dysplastické rysy jsou přítomny ve více než 50% erytroidních buněk. Description: Myeloblasts represent about 30% of all nucleated bone marrow cells. There is also erythroid hyperplasia here - almost 50% in bone marrow cells differential count. Cells of erythroid lineage show dysplastic features - megaloblastic nuclei, bilnuclear cells or nuclear lobulisation, internuclear bridges, poorly hemoglobinised cytoplasm. These dysplastic features are presented in more than 50% of erythroid cells.
Type: bone marrow
Klíčová slova*: myeloblast, megaloblastic haematopoiesis, internuclear bridges
Megaloblasic erythropoiesis- BM
Multilobular erythroblast can also occur, but this feature is less strongly associated with megaloblastic erythropoiesis unless co-existing myelodysplastic syndrome. / Může se taktéž objevit vícejaderný erytroblast, ale tento nález je méně významně spojen s megaloblastovou přestavbou pokud není současně přítomen myelodysplastický syndrom. Description: Multilobular erythroblast can also occur, but this feature is less strongly associated with megaloblastic erythropoiesis unless co-existing myelodysplastic syndrome.
Type: bone marrow
Klíčová slova*: dysplasia