MDS RAEB II

Autor*: A. Kubíková

Description:
MDS is a clonal disorder of the hematopoiesis. The pathological cell clone replaces the normal hematopoiesis. The different type and degree of cytopenia in peripheral blood is accompanied by the finding of cell-rich bone marrow. The dysplasia of bone marrow in all cell lines of bone marrow is present. Subsequently the clone is evolving and more and more immature calls are seen in bone marrow and then also in peripheral blood.In RAEB II 10-19% of blasts are present in BM . The type RAEB II is accosiated with high probability of shift to acute leukaemia. In our case (boy, 14 years old) we can see blasts, high ferquency of Auer rods in blasts and dysplasia in granulocytopoiesis a megakaryopoiesis.

Zařazení*:
Refrakterní anémie s excesem blastů II

Přílohy*:

MDS RAEB II
On the picture there are 6 blasts wirh visible nucleoli, in the cytoplasm of one of the blasts on the left the Auer's rod is visible. / Na obrázku 6 blastů se zřetelnými jadérky, v cytoplasmě druhého blastu od spodního okraje Auerova tyč. Description: On the picture there are 6 blasts wirh visible nucleoli, in the cytoplasm of one of the blasts on the left the Auer's rod is visible.
Type: bone marrow
Klíčová slova*: Auer rod
MDS RAEB II
In the upper part of the picture there is large blast with distinct granular chromatin, without visible nucleoli, in the cytoplasm there are 4 Auer';s rods. / V horní části obrázku velký blast s jemně zrnitým chromatinem, bez zřetelných jadérek, v cytoplasmě 4 Auerovy tyče. Description: In the upper part of the picture there is large blast with distinct granular chromatin, without visible nucleoli, in the cytoplasm there are 4 Auer';s rods.
Type: bone marrow
Klíčová slova*: Auer rod
MDS RAEB II
In the left part on the picture there is immature megakaryocyte with single nucleus and withaut mature granulomer. In the right part of the picture we can see the beginning of the apoptosis of the neutrophil. In the myelocytes and metamyelocytes you can see hypergranularity. / V levé části obrázku nezralý megakaryocyt s nefragmentovaným jádrem a nevytvořeným granulomerem. V pravé části obrázku počínající apoptóza neutrofilu. V buňkách myelořady hypergranulace. Description: In the left part on the picture there is immature megakaryocyte with single nucleus and withaut mature granulomer. In the right part of the picture we can see the beginning of the apoptosis of the neutrophil. In the myelocytes and metamyelocytes you can see hypergranularity.
Type: bone marrow
Klíčová slova*: megakaryocyte, hypogranulation
MDS RAEB II
In the centre of the picture there is a dysplastic megakaryocyte with devided nucleus, maturation caryomere is seen on the left part of it's cytoplasm. Above this megakaryocyte you can see a lymphoblast with condensed chromatin. At the right there is a hypergranular band form of neutrophil. / Ve středu obrázku je dysplastický megakaryocyt s fragmentovaným jádrem, částečně v levé části vyzrává cytoplasma v karyomer. U horního okraje obrázku je lymfoblast (prstenčitě kondenzovaný chromatin), vpravo hypergranulovaná tyčka. Description: In the centre of the picture there is a dysplastic megakaryocyte with devided nucleus, maturation caryomere is seen on the left part of it's cytoplasm. Above this megakaryocyte you can see a lymphoblast with condensed chromatin. At the right there is a hypergranular band form of neutrophil.
Type: bone marrow
Klíčová slova*: megakaryocyte
MDS RAEB II
A nest of dysplastic megakaryocytes and megakaryoblasts. / Na obrázku hnízdo dysplastických megakaryocytů a megakaryoblastů. Description: A nest of dysplastic megakaryocytes and megakaryoblasts.
Type: bone marrow
Klíčová slova*: megakaryoblast, megaloblast
MDS RAEB II
Large metamyelocyte and three blasts with visible nucleoli. / Na obrázku je obrovský metamyelocyt a tři blasty s viditelnými jadérky. Description: Large metamyelocyte and three blasts with visible nucleoli.
Type: bone marrow
Klíčová slova*: metamyelocyte, giant metamyelocyte
MDS RAEB II
Three blasts. In the cytoplasm of the blast in the middle, there are clearly seen Auer's rods. Below the myelocyte there is a megaloblast. Hypergranulation in cells of myeloid lineage. / Na obrázku 3 blasty, v cyoplasmě prostředního zřetelné Auer.tyče. Pod myelocytem megaloblast. Hypergranulace v buňkách myelořady. Description: Three blasts. In the cytoplasm of the blast in the middle, there are clearly seen Auer's rods. Below the myelocyte there is a megaloblast. Hypergranulation in cells of myeloid lineage.
Type: bone marrow
Klíčová slova*: myelocyte, megaloblast, Auer rod, hypergranulation
MDS RAEB II
In the middle of this picture you can see a blast with clear Auer rods (visible clear nucleoli). On the left there is a large metamyelocyte. In cells of myeloid lineage a dense hypergranulation is visible. / Uprostřed obrázku blast s Auerovými tyčemi (zřetelná jadérka). Na levo velký metamyelocyt . Hrubá hypergranulace v buňkách myelořady. Description: In the middle of this picture you can see a blast with clear Auer rods (visible clear nucleoli). On the left there is a large metamyelocyte. In cells of myeloid lineage a dense hypergranulation is visible.
Type: bone marrow
Klíčová slova*: Auer rod, hypergranulation, giant metamyelocyte
MDS RAEB II
In the upper part of the picture note a myeloblast wiht Auer rods, and nucleoli. Below this cell there is a plasmatic cell and two promyelocytes. On the right there is a group of two megaloblasts and two normoblast. / V horní části obrázku leží myeloblast s několika Auerovými tyčemi, v jádře zřetelná jadérka, pod ním plasmatická buňka a dva promyelocyty. Vpravo skupina erytroblastů se 2 normoblasty a 2 megaloblasty. Description: In the upper part of the picture note a myeloblast wiht Auer rods, and nucleoli. Below this cell there is a plasmatic cell and two promyelocytes. On the right there is a group of two megaloblasts and two normoblast.
Type: bone marrow
Klíčová slova*: myeloblast, normoblast, plasma cell, megaloblast, Auer rod
RAEB II corrected
/ Description:
Type: bone marrow