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Nalezené studie* (n=2)
id | název* | obrázků* | autor* | vytvořeno* | modifikováno* | schváleno* | schválil* |
---|---|---|---|---|---|---|---|
166 | cs: Anaplastický velkobuněčný lymfom - ALK negativní en: Anaplastic large cell lymphoma - ALK negative |
11 | Monika Antošová, A. Buliková, J. Kissová | 22.6.2008, 21:28 | 22.7.2008, 14:28 | 22.7.2008, 14:28 | J. Kissová |
129 | cs: Malobuněčný bronchiální karcinom en: Small-cell bronchial carcinoma |
5 | Monika Antošová, A. Buliková, J. Kissová | 20.1.2008, 1:39 | 14.9.2009, 21:32 | 14.9.2009, 21:32 | J. Kissová |
Nalezené obrázky* (n=43)
microgranular variant APL- BM, MPOX
Description: Myeloperoxidase reaction is strongly positive in contrast with "monocyte appearance" of some tumour cells in variant APL (in monocytes is usually weak or almost negative MPOX reaction). This finding can support suspicion to granulocytic origin of leukemic cells.
Type: bone marrow
Klíčová slova*: myeloperoxidase stain

Type: bone marrow
Klíčová slova*: myeloperoxidase stain
microgranular variant APL- BM
Description: Four tumour cells in variant APL with bi-lobar nuclei, rather fine cytoplasmic granulation and cytoplasmic projections at the outline of the cell. There is one typical hypergranular promyelocyte at the upper left with cytoplasm filed by large numerous azurophilic granules, which totally obscure the nuclear cytoplasmic margin.
Type: bone marrow
Klíčová slova*: promyelocyte

Type: bone marrow
Klíčová slova*: promyelocyte
microgranular variant APL- BM
Description: Bi-lobar or irregular nuclear shape in variant PML. There is one faggot cell at the upper left. Some tumour cells in variant APL can have cytoplasmic protrusions (four from five cells in lower part of the picture)-
Type:
Klíčová slova*: faggot cell

Type:
Klíčová slova*: faggot cell
microgranular variant APL- BM
Description: Bi-lobular or multilobular (cell at the middle right) nuclei and fine reddish granulation in cytoplasm are also typical in tumour cells in bone marrow.
Type: bone marrow
Klíčová slova*: promyelocyte

Type: bone marrow
Klíčová slova*: promyelocyte
microgranular variant APL- PB
Description: Tumour cell with bi-lobar nucleus, clear nucleoli in every nuclear part, some (upper left) or no (lower right) cytoplasmic granulation.
Type: peripheral blood
Klíčová slova*: promyelocyte, tumour cell

Type: peripheral blood
Klíčová slova*: promyelocyte, tumour cell
microgranular variant APL-PB
Description: The main feature of this type acute myeloblastic leukaemia is bi-lobed nuclear shape and presence of dust-like reddish granules in cytoplasm. Some tumour cells can be even agranular. Leukocytosis is usual when one compares this type with classic hyper-granular form.
Type: peripheral blood
Klíčová slova*: promyelocyte, tumour cell

Type: peripheral blood
Klíčová slova*: promyelocyte, tumour cell
Anaplastic large cell lymphoma - ALK negative
Description: Tumour cells can be smaller in lymphohistiocytic variant of ALCL - in this case malignant lymphoma cell has cleft or bi-lobar nucleus, abundant vacuolized cytoplasm and cytoplasmic blebs; it is almost comparable in size with immature myelocyte on it's left (both cell at upper right).
Type: bone marrow
Klíčová slova*: myelocyte, tumour cell

Type: bone marrow
Klíčová slova*: myelocyte, tumour cell
Medulloblastom
Description: Centrally a medulloblastoma cells rosette, with low magnification nucleoli not visible, evident vacuolisation in nuclei as well as in cytoplasm. too.
Type: bone marrow
Klíčová slova*: tumour cell

Type: bone marrow
Klíčová slova*: tumour cell
Medulloblastom
Description: BM metastasis.Large cluster of malignant cells with polymorphic cellular and nuclear shape and size.Nuclei rather eccentrically located, irregular or lobed, some with large nuclei.Marked vacuoles of basophilic cytoplasm and also of some of the nuclei.Left upper part of the picture shows a segmented neutrophile and a hypogranular myelocyte.
Type: bone marrow
Klíčová slova*: tumour cell

Type: bone marrow
Klíčová slova*: tumour cell
Medulloblastom
Description: medulloblastoma cells in BM, mostly with intracelullar vacuoles In the centre there is a tumor cell with a large vacuole. Few nuclear shadows seen
Type: bone marrow
Klíčová slova*: nuclear shadows, vacuolisation, tumour cell

Type: bone marrow
Klíčová slova*: nuclear shadows, vacuolisation, tumour cell
Medulloblastom
Description: A cluster of medulloblastoma cells of unequal size with nuclear chromatin of a coarse structure In some of the cells there are nucleoli, irregular cell membrane , with incisions, occasionally with incipient lobulisation.Cytoplasm basophilic, locally with slightly acidophilic areas. Cytoplasm is markedly vacuolised, in some of the cells there are vacuoles also in the nuclei,
Type: bone marrow
Klíčová slova*: tumour cell

Type: bone marrow
Klíčová slova*: tumour cell
Medulloblastom
Description: medulloblastoma cells in BM with nuclear shadows, mitosis in the centre
Type: bone marrow
Klíčová slova*: mitosis, nuclear shadows, tumour cell

Type: bone marrow
Klíčová slova*: mitosis, nuclear shadows, tumour cell
Medulloblastom
Description: A group of medulloblastoma cells on the imprint of a trepanobioptic sample shows cells of a middle and smaller size with round and lightly lobular nuclei, in some of them with visible nucleoli. Some nuclei contain vacuoles, which are sporadically or more frequently present also in the basophiklic cytoplasm.
Type: bone marrow
Klíčová slova*: tumour cell

Type: bone marrow
Klíčová slova*: tumour cell
Medulloblastom
Description: Picture similar to previous but with hogher magnification (1000x) .Distinctive infiltration of BM with medulloblastoma cells, some of them with marked vacuoles of nucleus and cytoplasm.. In some cells clearly seen nucleolus in the nucleus.
Type: bone marrow
Klíčová slova*: tumour cell

Type: bone marrow
Klíčová slova*: tumour cell
Medulloblastom
Description: In low magnification a monomorfic tumor cell population. With this magnification nucleoli in nuclei non visible, In some cells there are cytoplasmic vacuoles,. Vacuoles seen also in nuclei.
Type: bone marrow
Klíčová slova*: tumour cell

Type: bone marrow
Klíčová slova*: tumour cell
Medulloblastom-MPOX reaction
Description: negative MPOX in medulloblastoma cells, positive reaction in granulocytes only
Type: bone marrow
Klíčová slova*: tumour cell, myeloperoxidase stain

Type: bone marrow
Klíčová slova*: tumour cell, myeloperoxidase stain
Medulloblastom
Description: negative PAS (glykogen) reaction in medulloblastoma cells, diferential diagnostic aid toward rhabdomyosarcoma cells (RMS)
Type: bone marrow
Klíčová slova*: tumour cell, periodic acid-Schiff stain

Type: bone marrow
Klíčová slova*: tumour cell, periodic acid-Schiff stain
Medulloblastom
Description: Alfa-naphtyl-acetate-esterase (ANAE) reaction is in meduloblastoma equally asi in neuroblastoma positive and is blocked by Na-fluoride
Type: bone marrow
Klíčová slova*: tumour cell, non-specific esterase stain

Type: bone marrow
Klíčová slova*: tumour cell, non-specific esterase stain
Medulloblastom
Description: naphtyl-acetate-esterase (ANAE) reaction is in meduloblastoma equally asi in neuroblastoma positive and is blocked by Na-fluoride
Type:
Klíčová slova*: tumour cell, non-specific esterase stain

Type:
Klíčová slova*: tumour cell, non-specific esterase stain
Medulloblastom-Acid phosphatase reaction
Description: Medulloblastomoa cells in BM with positive AP (acid phosphatase) staining, (Similar finding to neuroblastoma)
Type: bone marrow
Klíčová slova*: tumour cell, acid phosphatase stain

Type: bone marrow
Klíčová slova*: tumour cell, acid phosphatase stain
Medulloblastom BE
Description: Medulloblastoma cells in BM, negative for butyrat-esterase staining
Type: bone marrow
Klíčová slova*: tumour cell, butyrate esterase

Type: bone marrow
Klíčová slova*: tumour cell, butyrate esterase
Anaplastic large cell lymphoma - ALK negative
Description: Three tumour cells in ALCL. They have pale basophilic cytoplasm, fine reticular nuclear chromatin and few dark blue nucleoli. There are two nuclear fragments in cytoplasm one of them (upper left). At the upper right are two immature neutrophils (upper promyelocyte, lower myelocyte).
Type: bone marrow
Klíčová slova*: promyelocyte, myelocyte, tumour cell

Type: bone marrow
Klíčová slova*: promyelocyte, myelocyte, tumour cell
Anaplastic large cell lymphoma - ALK negative
Description: Bi-nuclear tumour cell in ALCL T- lymphoma. Each nucleus contains few various size dark blue nucleoli. Nuclear chromatin is rather fine of reticular appearance. Cell has abundant moderately basophilic cytoplasm with cytoplasmic protrusions (at right).
Type: bone marrow
Klíčová slova*: tumour cell

Type: bone marrow
Klíčová slova*: tumour cell
Anaplastic large cell lymphoma - ALK negative
Description: One tumour cell in ALCL (middle right) - large cell with fine nuclear chromatin, prominent nucleolus, abundant cytoplasm which basophilia passes to eosinophilia. There are also three neutrophil myelocytes (upper one is destroyed), one lymphocyte (at 3 o'clock). The last cell in the picture is macrophage (between two myelocytes). These cells are typical component of this lymphohistiocytic variant of the lymphoma .
Type: bone marrow
Klíčová slova*: myelocyte, macrophage, tumour cell

Type: bone marrow
Klíčová slova*: myelocyte, macrophage, tumour cell
Anaplastic large cell lymphoma - ALK negative
Description: The large cell or one can say almost giant one tumour cell in blood marrow in ALCL and ALK negative T- cell lymphoma. Kidney shape of nucleus is rather typical as also they are multiple nuclei. Cytoplasm is abundant when one compares it with immature nucleus chromatin pattern.
Type: bone marrow
Klíčová slova*: lymphocyte atypical

Type: bone marrow
Klíčová slova*: lymphocyte atypical
Splenic marginal zone B- cell lymphoma
Description: Massive bone marrow infiltration by lymphoma cells. Their nuclei have condensed chromatin, about half of the cells express small nucleolus. Only very few of the cells are more immature ones (cell in the middle at 3 o'clock) with more immature chromatin and high N/C ratio. Cytoplasm of the most tumour cells have some projections.
Type: bone marrow
Klíčová slova*: lymphocyte atypical

Type: bone marrow
Klíčová slova*: lymphocyte atypical
Splenic marginal zone B- cell lymphoma
Description: Middle size cells with rather abundant cytoplasm with villi. When one compare there cells with tumour cells of hairy cell leukaemia, they have more basophilic cytoplasm and cytoplasmic projections are more thick and less numerous.
Type: peripheral blood
Klíčová slova*: lymphocyte atypical

Type: peripheral blood
Klíčová slova*: lymphocyte atypical
Hairy cell leukaemia- BM
Description: Smears of bone marrow aspirate use to be pure because aspiration is usually difficult or even impossible. Tumour cells can represent only minority cell population. Cells are the most often medium-size, but larger then normal lymphocyte. They have abundant weakly basophilic cytoplasm with irregular cytoplasmic margins. The cell at upper right contains few cytoplasmic inclusions.
Type: bone marrow
Klíčová slova*: cytoplasmic inclusion, hairy cell

Type: bone marrow
Klíčová slova*: cytoplasmic inclusion, hairy cell
Hairy cell leukaemia- BM
Description: In this case of hairy cell leukemia smears shows unusually large tumour cells (usually medium-size), with irregular nucleus shape and/or cleft . Chromatin of the nucleus is spongy, less clumped than that of a normal lymphocyte.
Type: bone marrow
Klíčová slova*: hairy cell

Type: bone marrow
Klíčová slova*: hairy cell
Small- cell bronchial carcinoma - BM
Description: The last example bone marrow tumour cells' infiltration in this case - the cluster of various size tumour cells with immature appearance, narrow rim of basophilic cytoplasm and with fine chromatin and a few nucleoli in nucleus. There are two late erythroblasts at the left side of the picture.
Type: bone marrow
Klíčová slova*: polychromatophilic normoblast, orthochromatophilic normoblast, tumour cell

Type: bone marrow
Klíčová slova*: polychromatophilic normoblast, orthochromatophilic normoblast, tumour cell
Small - cell bronchial carcinoma - BM
Description: Tumour cells' infiltration - cluster of various size immature cells with narrow cytoplasm's rim, fine chromatin and nucleoli; there is late erythroblast at the upper right and there are some naked nucleoli at the smear.
Type: bone marrow
Klíčová slova*: orthochromatophilic normoblast, naked nucleus, tumour cell

Type: bone marrow
Klíčová slova*: orthochromatophilic normoblast, naked nucleus, tumour cell
Small- cell bronchial carcinoma - BM
Description: Tumour cells' infiltration of the bone marrow - cluster of smaller to middle size cells with high nucleus - cytoplasm ratio, there is fine chromatin in the nucleus with one to more nucleoli.
There is one hypergranular neutrophile myelocyte at left side, segmented neuthrophil with pseudo-pelgeroid appearance at the top and late erythroblast at the upper left, there are same naked nucleoli at the smear.
Type: bone marrow
Klíčová slova*: myelocyte, orthochromatophilic normoblast, hypergranulation, naked nucleus, tumour cell

Type: bone marrow
Klíčová slova*: myelocyte, orthochromatophilic normoblast, hypergranulation, naked nucleus, tumour cell
Small- cell bronchial carcinoma - BM
Description: The first example of the bone marrow infiltration in this case - the cluster of the middle size cells with narrow rim of basophilic cytoplasm; there is fine chromatin and some nucleoli in the nucleus. There is eosinophil metamyelocyte at the upper left, neutrophil metamyelocyte at the upper right and there are two late erythroblasts at the upper part of the picture. Naked nucleoli are the typical content of the smear.
Type: bone marrow
Klíčová slova*: metamyelocyte, orthochromatophilic normoblast, naked nucleus, tumour cell

Type: bone marrow
Klíčová slova*: metamyelocyte, orthochromatophilic normoblast, naked nucleus, tumour cell
Small- cell bronchial carcinoma - BM
Description: Bone marrow smear in smaller enlargement - massive tumour cells' infiltration in clusters.
Type: bone marrow
Klíčová slova*: tumour cell

Type: bone marrow
Klíčová slova*: tumour cell
AML M5b bone marrow
Description: Tumour cells can phagocyte one another in acute monocytic leukaemia.
Type: bone marrow
Klíčová slova*: monoblast, promonocyte, monocyte

Type: bone marrow
Klíčová slova*: monoblast, promonocyte, monocyte
AML M5b bone marrow
Description: Mitosis in tumour cell. There are destroyed erythrocytes in the leukemic cell at 3 o'clock.
Type: bone marrow
Klíčová slova*: hemophagocytosis, mitosis

Type: bone marrow
Klíčová slova*: hemophagocytosis, mitosis
AML M5b bone marrow
Description: Pronounced phagocytosis in tumour cells. Cytoplasm of the cell in the middle is completely loaded by erythrocytes. The neighbouring cells (bellow and at left) have naked nuclei in their cytoplasm.
Type: bone marrow
Klíčová slova*: hemophagocytosis

Type: bone marrow
Klíčová slova*: hemophagocytosis
DSRCT-Tumor print
Description: Metastasis in scull. Tumor cells are morfologically simmilar to those in bone marrow, but they have more cytoplasm.
Type: tumor print
Klíčová slova*: tumour cell

Type: tumor print
Klíčová slova*: tumour cell
DSRCT-Tumor cells in bone marrow
Description: Tumor cell with 2 nuclei on the right side of the picture. Numerous other patologic cells.
Type: bone marrow
Klíčová slova*: tumour cell

Type: bone marrow
Klíčová slova*: tumour cell
DSRCT-Tumor cells in bone marrow
Description: Cluster of tumor cells.
Type: bone marrow
Klíčová slova*: tumour cell

Type: bone marrow
Klíčová slova*: tumour cell
DSRCT-Tumor cells in bone marrow
Description: Tumor cells have round, slightly excentric nucleus with fine chromatin. Nucleoli are not prominent. Cytoplasm is blue, without vacuolisation or granulation. N/C>1.
Type: bone marrow
Klíčová slova*: tumour cell

Type: bone marrow
Klíčová slova*: tumour cell
DSRCT-Tumor cells in bone marrow (200x)
Description: Bone marrow aspirate. Cluster of tumor cells among normal haematopoietic cells.
Type: bone marrow
Klíčová slova*: tumour cell

Type: bone marrow
Klíčová slova*: tumour cell
AMML Eo bone marrow
Description: Hyper-cellular bone marrow with mixture of tumour cells of granulocytic and monocytic lineages. Two characteristic eosinophil myelocytes, that in at right has vacuolized cytoplasm. Eosinophil the mostly at right is promyelocyt with numerous purple pro-granules.
Type: bone marrow
Klíčová slova*: myeloblast, promyelocyte, eosinophil, promonocyte, monocyte

Type: bone marrow
Klíčová slova*: myeloblast, promyelocyte, eosinophil, promonocyte, monocyte