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AML without maturation- BM
Hypercellular bone marrow with dominant population of myeloblasts. Only one segmented neutrophil is above the picture's centre, it is hypogranular. There is also one mature plasmocyte at 11 o'clock. Due to rich smear not all cells can be definitely distinguished. / Hypercelulární kostní dřen s převažující populací myeloblastů. Jen jeden neutrofilní segment je nad středem obráźku, je hypogranulovaný. Jeden zralý plazmocyt je také na 11. hodině. Z důvodů bohatého nátěru ne všechny buňky mohou být s jistotou rozpoznány. Description: Hypercellular bone marrow with dominant population of myeloblasts. Only one segmented neutrophil is above the picture's centre, it is hypogranular. There is also one mature plasmocyte at 11 o'clock. Due to rich smear not all cells can be definitely distinguished.
Type: bone marrow
Klíčová slova*: myeloblast, segmented granulocyte, plasma cell
Chronic myelogenous leukaemia - chronic phase
Various stages of maturation in neutrophil lineage (one myeloblast in the centre, two segments and metamyelocyte). Only one early normoblast is under the myeloblast; beside it to the left is basophil. / Různá stádia vyzrávání v neutrofilní řadě (jeden myeloblast v centru, dva segmenty a metamyelocyt). Jen jeden časný normoblast je pod myeloblastem, vedle něj doleva je basofil. Description: Various stages of maturation in neutrophil lineage (one myeloblast in the centre, two segments and metamyelocyte). Only one early normoblast is under the myeloblast; beside it to the left is basophil.
Type: bone marrow
Klíčová slova*: myeloblast, metamyelocyte, basophil, segmented granulocyte, normoblast
Chronic myelogenous leukaemia - chronic phase
Hyperplastic bone marrow with increased number of neutrophil segment and their precursors. Maturation pattern is similar to that in perifpheral blood - predominant populations represent mature neutrophils and myelocytes. There are three eosinofiphils in this part of slide (at 9, 3 and 4 o'clock). There isn't presence of significant dysgranulopoiesis . / Hyperplastická kostní dřeň se zvýšeným počtem neutrofilních segmentů a jejich prekurzorů. Rozložení vyzrávání je obdobné jako v periferní krvi - dominující populace jsou představovány zralými neutrofily a myelocyty. V této části nátěru jsou tři eozinofily (na 9., 3. a 4. hodině). Není přítomna zřetelná dysgranulopoéza. Description: Hyperplastic bone marrow with increased number of neutrophil segment and their precursors. Maturation pattern is similar to that in perifpheral blood - predominant populations represent mature neutrophils and myelocytes. There are three eosinofiphils in this part of slide (at 9, 3 and 4 o'clock). There isn't presence of significant dysgranulopoiesis .
Type: bone marrow
Klíčová slova*: myelocyte, eosinophil, segmented granulocyte
Chronic myelogenous leukaemia - chronic phase
Although predominant populations in peripheral blood smears in the disease represent mature segmented neutrophils and myelocytes, all type of immature cells of granulocytic lineage can occur. There are two bands in the picture (2 o'clock and 7 o'clock), and there is one promyelocyte (at 8 o'clock). / I když dominujícími populacemi u této choroby jsou v nátěru periferní krve neutrofilní segmenty a myelocyty, mohou se objevit všechny nezralé buňky granulocytární řady. Na obrázku jsou dvě tyče (na 2. a 7. hodině) a promyelocyt (na 8. hodině). Description: Although predominant populations in peripheral blood smears in the disease represent mature segmented neutrophils and myelocytes, all type of immature cells of granulocytic lineage can occur. There are two bands in the picture (2 o'clock and 7 o'clock), and there is one promyelocyte (at 8 o'clock).
Type: peripheral blood
Klíčová slova*: promyelocyte, myelocyte, band, segmented granulocyte
Chronic myelogenous leukaemia - chronic phase
Peripheral blood smear shows numerous granulocytes with predominate segmented neutrophils and myelocytes (four of them are in the picture). / Nátěry periferní krve ukazují početné granulocyty s predominancí segmentovaných neutrofilů a myelocytů (čtyři na obrázku). Description: Peripheral blood smear shows numerous granulocytes with predominate segmented neutrophils and myelocytes (four of them are in the picture).
Type: peripheral blood
Klíčová slova*: myelocyte, segmented granulocyte
CML accelerated phase - PB
Predominance of segmented granulocytes, neutrophil band in the centre, eosinophil myelocyte at the right side bottom, cluster of three blasts in the centre. / Převaha neutrofilních segmentů, neutrofilní tyč uprostřed, eozinofilní myelocyt vpravo dole, shluk tří blastů uprostřed. Description: Predominance of segmented granulocytes, neutrophil band in the centre, eosinophil myelocyte at the right side bottom, cluster of three blasts in the centre.
Type: peripheral blood
Klíčová slova*: myeloblast, eosinophil, band, segmented granulocyte
CML accelerated phase - PB
Marked leucocytosis with granulocytosis. Myelocytes and segmented granulocytes are predominant elements of peripheral blood, marked basophilia. At the picture blasts and promyelocytes are present, six basophiles. / Výrazná leukocytóza s granulocytózou. Myelocyty a neutrofilní segmenty jsou dominujícími elementy v nátěrech periferní krve, výrazná bazofílie. Na obrázku přítomny i blasty a promyelocyty, šest bazofilů. Description: Marked leucocytosis with granulocytosis. Myelocytes and segmented granulocytes are predominant elements of peripheral blood, marked basophilia. At the picture blasts and promyelocytes are present, six basophiles.
Type: peripheral blood
Klíčová slova*: myeloblast, promyelocyte, myelocyte, basophil, segmented granulocyte
CML accelerated phase - BM
Hyperplastic bone marrow with increased number of granulopoetic cells, predominant population represent myelocytes and segmented granulocytes, eosinophiles and blasts are increased, basophilia. Two blasts are present - one is in the centre and one is on the right side up (on the 2 o'clock).Two basophiles are present - one is slightly right up and one at the left side bottom. Eosinophil myelocyte is present on the right upper border of the picture. / Hyperplastická kostní dřeň se zmnožením buněk granulopoezy, dominující populací jsou myelocyty a neutrofilní segmenty, zmnoženy blasty, výrazná bazofílie. Přítomny dva blasty, jeden uprostřed a jeden vpravo nahoře( na 2. hodině) a dva bazofily - jeden mírně vpravo nahoře a jeden vlevo dole. Eosinofilní myelocyt je při pravém horním okraji obrázku. Description: Hyperplastic bone marrow with increased number of granulopoetic cells, predominant population represent myelocytes and segmented granulocytes, eosinophiles and blasts are increased, basophilia. Two blasts are present - one is in the centre and one is on the right side up (on the 2 o'clock).Two basophiles are present - one is slightly right up and one at the left side bottom. Eosinophil myelocyte is present on the right upper border of the picture.
Type: bone marrow
CML accelerated phase - BM
Hyperplastic bone marrow with increased number of granulopoetic cells, predominant population represent myelocytes and segmented granulocytes, blasts are increased, marked basophilia. Two blasts are present - one is in the centre bottom and one is on the right side ( on the 2 o'clock).Three basophiles are present - one in the centre and two at the right side of the picture. / Hyperplastická kostní dřeň se zmnožením buněk granulopoezy, dominující populací jsou myelocyty a neutrofilní segmenty, zmnoženy blasty, je výrazná bazofílie. Přítomny dva blasty, jeden dole uprostřed a jeden vpravo ( na 2. hodině). Jsou přítomny tři bazofily - jeden uprostřed a dva na pravé straně obrázku. Description: Hyperplastic bone marrow with increased number of granulopoetic cells, predominant population represent myelocytes and segmented granulocytes, blasts are increased, marked basophilia. Two blasts are present - one is in the centre bottom and one is on the right side ( on the 2 o'clock).Three basophiles are present - one in the centre and two at the right side of the picture.
Type: bone marrow
Klíčová slova*: myeloblast, myelocyte, metamyelocyte, basophil, segmented granulocyte
CML accelerated phase - BM
Hyperplastic bone marrow with increased number of granulopoetic cells, predominant population represent myelocytes and segmented granulocytes, blasts and eosinophiles are increased. Blast is on the right side bottom , two eosinophil myelocytes are present - one up and one at the bottom in the centre of the picture. / Hyperplastická kostní dřeň se zmnožením buněk granulopoezy, dominující populací jsou myelocyty a neutrofilní segmenty, zmnoženy blasty a eozinofily. Blast vlevo dole, dva eozinofilní myelocyty - jeden nahoře a jeden dole uprostřed obrázku. Description: Hyperplastic bone marrow with increased number of granulopoetic cells, predominant population represent myelocytes and segmented granulocytes, blasts and eosinophiles are increased. Blast is on the right side bottom , two eosinophil myelocytes are present - one up and one at the bottom in the centre of the picture.
Type: bone marrow
Klíčová slova*: myeloblast, myelocyte, metamyelocyte, eosinophil, band, segmented granulocyte
CML accelerated phase - BM
Hyperplastic bone marrow with increased number of granulopoetic cells, predominant population represent myelocytes and segmented granulocytes, blasts and eosinophiles are increased, marked basophilia. Blasts are in the centre and on the right and left side (at 9 and 2 o'clock), eosinophil is in the centre below segmented granulocyte. Four basophiles are present - two at the right side up and two at the bottom part of the picture. / Hyperplastická kostní dřeň se zmnožením buněk granulopoezy, dominující populací jsou myelocyty a neutrofilní segmenty, zmnoženy blasty a eozinofily, výrazná bazofilie. Blasty uprostřed , dále vlevo i vpravo (na 9.a 2.hodině), eozinofil uprostřed pod neutrofilním segmentem,. Bazofilyjsou přítomny 4, dva vpravo nahoře a dva ve spodní části obrázku. Description: Hyperplastic bone marrow with increased number of granulopoetic cells, predominant population represent myelocytes and segmented granulocytes, blasts and eosinophiles are increased, marked basophilia. Blasts are in the centre and on the right and left side (at 9 and 2 o'clock), eosinophil is in the centre below segmented granulocyte. Four basophiles are present - two at the right side up and two at the bottom part of the picture.
Type: bone marrow
Klíčová slova*: myeloblast, myelocyte, eosinophil, basophil, band, segmented granulocyte
Chronická lymfatická leukémie/malobuněčný lymfom
Numerous small lymphocytes and one segmented neutrophil (at 6 o'clock). Broken cell are typically seen in the smears. They are characteristic but nor pathognomic since they are occasionally seen in a variety other conditions. But only in CLL they are known as "Gumprecht's shades". / Početné malé lymfocyty a jeden neutrofilní segment (na 6. hodině). Rozbité buňky jsou typicky patrné v nátěrech. Jsou charakteristické ale ne patognomické, protože je možné je občas najít i u různých jiných stavů. Avšak jen u CLL jsou známy jako "Gumprechtovy stíny". Description: Numerous small lymphocytes and one segmented neutrophil (at 6 o'clock). Broken cell are typically seen in the smears. They are characteristic but nor pathognomic since they are occasionally seen in a variety other conditions. But only in CLL they are known as "Gumprecht's shades".
Type: bone marrow
Klíčová slova*: segmented granulocyte, lymphocyte, nuclear shadows
AML M5b bone marrow - MPOX
Monoloblast are typically myeloperoxidase negative, promonocytes may show some scattered MPOX positivity (probably larger cell at 8 o'clock; that smaller one is positive segmented granulocyte). / Monoblasty jsou typicky myeloperoxidáza negativní, promonocyty mohou vykazovat jistou roztroušenou MPOX pozitivitu (pravděpodobně větší buňka na 8. hodině; ta menší je pozitivní neutrofilní segment). Description: Monoloblast are typically myeloperoxidase negative, promonocytes may show some scattered MPOX positivity (probably larger cell at 8 o'clock; that smaller one is positive segmented granulocyte).
Type: bone marrow
Klíčová slova*: segmented granulocyte, monoblast, promonocyte
AML M5b bone marrow
Promonocytes, monocytes and one monoblast (at 5 o'clock). The presence of neutrophil cells can be rarely find (segmented neutrophil at 11 o'clock). Monocytic lineage represents > 80% nucleated bone marrow cells. / Promonocyty, monocyty a jeden monoblast (na 5. hodině). Vzácně může být zastižena přítomnost neutrofilních buněk (neutrofilní segment na 11. hodině). Monocytární řada představuje > 80 % jaderných buněk dřeně. Description: Promonocytes, monocytes and one monoblast (at 5 o'clock). The presence of neutrophil cells can be rarely find (segmented neutrophil at 11 o'clock). Monocytic lineage represents > 80% nucleated bone marrow cells.
Type: bone marrow
Klíčová slova*: segmented granulocyte, monoblast, promonocyte, monocyte
AML M5b peripheral blood
One segmented neutrophil and two atypical monocytes - they have more basophilic cytoplasm and lower one has obvious and large nulceoli. / Jeden neutrofilní segment a dva atypické monocyty - mají více basofilní cytoplazma a spodní má jasná a velká jadérka. Description: One segmented neutrophil and two atypical monocytes - they have more basophilic cytoplasm and lower one has obvious and large nulceoli.
Type: peripheral blood
Klíčová slova*: segmented granulocyte, monocyte
AMML Eo peripheral blod
Monocytes in peripheral blood reach to 47% (absolute number 12,7G/l) at the time of diagnosis. One segmented neutrophil at 4 o'clock. / Monocyty v periferní krvi dosahují v čase diagnózy 47% (absolutní počet 12,7G/l)- Jeden neutrofilní segment na 4. hodině. Description: Monocytes in peripheral blood reach to 47% (absolute number 12,7G/l) at the time of diagnosis. One segmented neutrophil at 4 o'clock.
Type: peripheral blood
Klíčová slova*: segmented granulocyte, monocyte
CML - bone marrow
Hyperplastic bone marrow with an increase of the granulocytic line and with two peaks in the percentages of myelocytes and segmented neutrophils. / Hyperplastická kostní dřeň se zvýšením granulocytární řady s dvěma vrcholy v procentech myelocytů a neutroiflních segmentů. Description: Hyperplastic bone marrow with an increase of the granulocytic line and with two peaks in the percentages of myelocytes and segmented neutrophils.
Type: bone marrow
Klíčová slova*: myelocyte, segmented granulocyte
CML - peripheral blood
Myelocytes and neutrophil segments are predominant cells in peripheral blood smears. / Myelocyty a neutrofilní segmenty jsou dominujícími elementy v nátěrech periferní krve. Description: Myelocytes and neutrophil segments are predominant cells in peripheral blood smears.
Type: peripheral blood
Klíčová slova*: myelocyte, segmented granulocyte
CML - bone marrow
Granulocytic hyperplasia - some eosinophils and basophils, predominant cells are mature neutrophils and myelocytes. Smear do not shows any marked dysplastic changes but one hypo-granular pseudo-pelgeroid segmented neutrophil (underneath centre of the picture at the 5 o'clock). / Granulocytární hyperplázie - několik eozinoiflů a bazofilů, dominujícími buňkami jsou zralé neutrofily a myelocyty. Nátěr neukazuje žádné zřetelné dysplastické změny s výjimkou jednoho hypogranulárního pseudo-pelgeroidního neutrofilního segmentu (pod centrem obrázku na 5. hodině). Description: Granulocytic hyperplasia - some eosinophils and basophils, predominant cells are mature neutrophils and myelocytes. Smear do not shows any marked dysplastic changes but one hypo-granular pseudo-pelgeroid segmented neutrophil (underneath centre of the picture at the 5 o'clock).
Type: bone marrow
Klíčová slova*: myelocyte, eosinophil, basophil, segmented granulocyte, pseudo-Pelger anomaly, hypogranulation
CML - peripheral blood
Smear shows numerous myelocytes and segmented neutrophils. One basophil at the 8 o'clock. / Nátěr ukazuje četné myelocyty a neutrofilní segmenty. Jeden basofil na 8. hodině. Description: Smear shows numerous myelocytes and segmented neutrophils. One basophil at the 8 o'clock.
Type: peripheral blood
Klíčová slova*: myelocyte, basophil, segmented granulocyte
CML - peripheral blood
In the middle of the picture are myelocytes, segmented neutrophils and two rather immature eosinophils. Mature basophil is on the left. / Uprostřed obrázku jsou myelocyty, neutrofilní segmenty a dva spíše nezralé eozinofily. Zralý basofil je nalevo. Description: In the middle of the picture are myelocytes, segmented neutrophils and two rather immature eosinophils. Mature basophil is on the left.
Type: peripheral blood
Klíčová slova*: myelocyte, eosinophil, basophil, segmented granulocyte