Medulloblastoma,BM infiltration
Autor*: S. Valníček, Světlana Köhlerová, Bára Jordanová, O. Zapletal
Description:
Girl, currently 7 years of age, with dg. of medulloblastoma fossae cranii posterioris, According to histology,classical type, diagnosed 9 months ago, currently with multiple metastases, including BM. Planned therapy denied by parents. Actually on palliative treatment in hospice only.
Zařazení*:
Neuroblastoma
Přílohy*:
Medulloblastom
Description: In low magnification a monomorfic tumor cell population. With this magnification nucleoli in nuclei non visible, In some cells there are cytoplasmic vacuoles,. Vacuoles seen also in nuclei.
Type: bone marrow
Klíčová slova*: tumour cell
Medulloblastom
Description: Centrally a medulloblastoma cells rosette, with low magnification nucleoli not visible, evident vacuolisation in nuclei as well as in cytoplasm. too.
Type: bone marrow
Klíčová slova*: tumour cell
Medulloblastom
Description: A group of medulloblastoma cells on the imprint of a trepanobioptic sample shows cells of a middle and smaller size with round and lightly lobular nuclei, in some of them with visible nucleoli. Some nuclei contain vacuoles, which are sporadically or more frequently present also in the basophiklic cytoplasm.
Type: bone marrow
Klíčová slova*: tumour cell
Medulloblastom
Description: Picture similar to previous but with hogher magnification (1000x) .Distinctive infiltration of BM with medulloblastoma cells, some of them with marked vacuoles of nucleus and cytoplasm.. In some cells clearly seen nucleolus in the nucleus.
Type: bone marrow
Klíčová slova*: tumour cell
Medulloblastom
Description: BM metastasis.Large cluster of malignant cells with polymorphic cellular and nuclear shape and size.Nuclei rather eccentrically located, irregular or lobed, some with large nuclei.Marked vacuoles of basophilic cytoplasm and also of some of the nuclei.Left upper part of the picture shows a segmented neutrophile and a hypogranular myelocyte.
Type: bone marrow
Klíčová slova*: tumour cell
Medulloblastom
Description: A cluster of medulloblastoma cells of unequal size with nuclear chromatin of a coarse structure In some of the cells there are nucleoli, irregular cell membrane , with incisions, occasionally with incipient lobulisation.Cytoplasm basophilic, locally with slightly acidophilic areas. Cytoplasm is markedly vacuolised, in some of the cells there are vacuoles also in the nuclei,
Type: bone marrow
Klíčová slova*: tumour cell
Medulloblastom
Description: medulloblastoma cells in BM with nuclear shadows, mitosis in the centre
Type: bone marrow
Klíčová slova*: mitosis, nuclear shadows, tumour cell
Medulloblastom
Description: medulloblastoma cells in BM, mostly with intracelullar vacuoles In the centre there is a tumor cell with a large vacuole. Few nuclear shadows seen
Type: bone marrow
Klíčová slova*: nuclear shadows, vacuolisation, tumour cell
Medulloblastom BE
Description: Medulloblastoma cells in BM, negative for butyrat-esterase staining
Type: bone marrow
Klíčová slova*: tumour cell, butyrate esterase
Medulloblastom-Acid phosphatase reaction
Description: Medulloblastomoa cells in BM with positive AP (acid phosphatase) staining, (Similar finding to neuroblastoma)
Type: bone marrow
Klíčová slova*: tumour cell, acid phosphatase stain
Medulloblastom
Description: naphtyl-acetate-esterase (ANAE) reaction is in meduloblastoma equally asi in neuroblastoma positive and is blocked by Na-fluoride
Type:
Klíčová slova*: tumour cell, non-specific esterase stain
Medulloblastom
Description: Alfa-naphtyl-acetate-esterase (ANAE) reaction is in meduloblastoma equally asi in neuroblastoma positive and is blocked by Na-fluoride
Type: bone marrow
Klíčová slova*: tumour cell, non-specific esterase stain
Medulloblastom-MPOX reaction
Description: negative MPOX in medulloblastoma cells, positive reaction in granulocytes only
Type: bone marrow
Klíčová slova*: tumour cell, myeloperoxidase stain
Medulloblastom
Description: negative MPOX in medulloblastoma cells, positive reaction in granulocytes only
Type: bone marrow
Medulloblastom
Description: negative PAS (glykogen) reaction in medulloblastoma cells, diferential diagnostic aid toward rhabdomyosarcoma cells (RMS)
Type: bone marrow
Klíčová slova*: tumour cell, periodic acid-Schiff stain