Chronic myelogenous leukaemia - chronic phase

Autor*: A. Buliková

Description:
18-years old girl with accidentally found leukocytosis (67 G/l) and mild thrombocytosis (487 G/l). Mild splenomegaly could be detected only by ultrasonography. Diagnosis CML was proved by t(9;22) chromosomal abnormality and by BCR/ABL fusion gene in molecular genetic examination.

Zařazení*:
Chronic myeloid leukaemia, BCR/ABL 1 positive

Přílohy*:

CML - peripheral blood
Myelocytes and neutrophil segments are predominant cells in peripheral blood smears. / Myelocyty a neutrofilní segmenty jsou dominujícími elementy v nátěrech periferní krve. Description: Myelocytes and neutrophil segments are predominant cells in peripheral blood smears.
Type: peripheral blood
Klíčová slova*: myelocyte, segmented granulocyte
CML - peripheral blood
Leukocytosis, left shift in neutrophil maturation and one basophil. (at the 11 o'clock). / Leukocytóza, posun doleva a jeden bazofil (na 11. hodině). Description: Leukocytosis, left shift in neutrophil maturation and one basophil. (at the 11 o'clock).
Type: peripheral blood
Klíčová slova*: basophil
CML - bone marrow, lower magnification
Bone marrow hypercellularity, granulocytic hyperplasia. Two hypo-segmented and smaller megakaryocytes are shown underneath the centre of the picture. / Hypercelularita kostní dřeně, granulocytární hyperplázie. Dva hyposegmentované a menší megakaryocyty jsou zobrazeny pod centrem obrázku Description: Bone marrow hypercellularity, granulocytic hyperplasia. Two hypo-segmented and smaller megakaryocytes are shown underneath the centre of the picture.
Type: bone marrow
Klíčová slova*: megakaryocyte, hyposegmentation
CML - bone marrow, lowe magnification
Hyper-cellular bone marrow with granulocytic hyperplasia and increased myeloid : erythroid ratio. The picture shows one smaller and hypo-segmented megakaryocyte at the middle. / Hypercelulární kostní dřeň s granulocytární hyperplázií a zvýšeným poměrem granulocyto : erytroidním. Obrázek zobrazuje jeden malý a hyposegementovaný megakaryocyt uprostřed. Description: Hyper-cellular bone marrow with granulocytic hyperplasia and increased myeloid : erythroid ratio. The picture shows one smaller and hypo-segmented megakaryocyte at the middle.
Type: bone marrow
Klíčová slova*: megakaryocyte, hyposegmentation
CML - bone marrow
The increase count of the smaller megakaryocytes with hypolobated nuclei is the typical change in megakaryocytic maturation in bone marrow. / Zvýšení počtu malých megakaryocytů s hypolobulizovanými jádry je typickou změnou ve vyzrávání megakryocytů v kostní dřeni. Description: The increase count of the smaller megakaryocytes with hypolobated nuclei is the typical change in megakaryocytic maturation in bone marrow.
Type: bone marrow
Klíčová slova*: megakaryocyte
CML - bone marrow
Hyperplastic bone marrow with an increase of the granulocytic line and with two peaks in the percentages of myelocytes and segmented neutrophils. / Hyperplastická kostní dřeň se zvýšením granulocytární řady s dvěma vrcholy v procentech myelocytů a neutroiflních segmentů. Description: Hyperplastic bone marrow with an increase of the granulocytic line and with two peaks in the percentages of myelocytes and segmented neutrophils.
Type: bone marrow
Klíčová slova*: myelocyte, segmented granulocyte