AML

Autor*: Jaroslava Hoblová, A. Buliková, J. Kissová

Description:
52 years old female patient with first line diagnose " white blood cells disorder". Cell blood count shows mild leukocytosis ( WBC 13,2G/l), macrocytic anemia (HGB 73,5 g/l, MCV 98,5fl) and severe thrombocytopenia (PLT 7,99 G/l). Peripheral blood smears shows presence of 77% blasts with Auer rods, which can be counted as myeloblasts. This finding allows diagnose of acute myeloid leukemia. Bone marrow smears evaluation with cytogenetic and/or molecular genetic examination is necessary for precise diagnose.

Zařazení*:
Acute myeloid leukaemias and related precursor neoplasms

Přílohy*:

AML- peripheral blood
The I-st type myeloblast in peripheral blood - without any azurophilic granules and/or Auer rods; according to irregular nucleus shape with two chromatin projections one could speculate about tumour origin of this cell. / Myeloblast I. typu - bez azurofilních granulí a/nebo Auerových tyčí; podle nepravidelného tvaru jádra s dvěma výběžky chromatinu lze přemýšlet o nádorovém původu této buňky. Description: The I-st type myeloblast in peripheral blood - without any azurophilic granules and/or Auer rods; according to irregular nucleus shape with two chromatin projections one could speculate about tumour origin of this cell.
Type: peripheral blood
Klíčová slova*: myeloblast
AML- peripheral blood
The I-st type myeloblast with high nucleo/cytoplasm ratio, fine chromatin and three nucleoli. Immature erythrocyte (macrocytic and rather polychromatiphilic) at 8 o'clock. / Myeloblast I. typu s vysokým poměrem jádro/cytoplazma, jemným chromatinem a třemi jadérky. Nezralý erytrocyt (makrocytární a spíše polychromatofilní) na 8. hodině. Description: The I-st type myeloblast with high nucleo/cytoplasm ratio, fine chromatin and three nucleoli. Immature erythrocyte (macrocytic and rather polychromatiphilic) at 8 o'clock.
Type: peripheral blood
Klíčová slova*: myeloblast
AML- peripheral blood
Two I- st type myeoblasts at the smear, the upper one with high nuclear/cytoplasm ratio seams to be really immature, the lower one is typical myeloblast appearance. / Dva myeloblasty I. typu v nátěru, ten horní s vysokým nukleo/cytoplazmatickým poměrem se zdá být skutečně nezralým, dolní má vzhled typického myeloblastu. Description: Two I- st type myeoblasts at the smear, the upper one with high nuclear/cytoplasm ratio seams to be really immature, the lower one is typical myeloblast appearance.
Type: peripheral blood
Klíčová slova*: myeloblast
AML- peripheral blood
The II-nd type myeloblast with Auer rod. / Myeloblast II. typu s Auerovou tyčí. Description: The II-nd type myeloblast with Auer rod.
Type: peripheral blood
Klíčová slova*: myeloblast, Auer rod
AML- peripheral blood
Another example of the II-nd type of myeloblast. Cytoplasm contains not only Auer rod but also fine azurophilic granulation. / Jiný příklad myeloblastu 2. typu. Cytoplazma obsahuje nejen Auerovu tyč, ale také jemnou azurofilní granulaci. Description: Another example of the II-nd type of myeloblast. Cytoplasm contains not only Auer rod but also fine azurophilic granulation.
Type: peripheral blood
Klíčová slova*: myeloblast, Auer rod
AML- peripheral blood
The II-nd type myeloblast. Cell with fine chromatin structure, high nucleus/cytoplasm ratio, three clear nucleoli. Large centrosome is discernible as a lighter juxtanuclear zone with a slight depression of the nucleus; this is sing of more mature cell ( promyelocyte of normal bone marrow). The apparent Auer rod is in the cytoplasm of the cell. . / Myeloblast II. typu. Buňka s jemnou strukturou chromatinu, vysokým nukleo/cytoplazmatickým poměrem, třemi jadérky. Velký centrosom je rozeznatelný jako světlejší juxtanukleární oblast s promáčknutím jádra; to je známka více zralé buňky (promyelocyt v normální kostní dřeni). Zřetelná Auerova tyč je v cytoplazmě buňky. Description: The II-nd type myeloblast. Cell with fine chromatin structure, high nucleus/cytoplasm ratio, three clear nucleoli. Large centrosome is discernible as a lighter juxtanuclear zone with a slight depression of the nucleus; this is sing of more mature cell ( promyelocyte of normal bone marrow). The apparent Auer rod is in the cytoplasm of the cell. .
Type: peripheral blood
Klíčová slova*: myeloblast, Auer rod
AML- peripheral blood
Peripheral blood smear in AML shows II-nd type myeloblast with Auer rod at the right and lymphocyte at the left. / Nátěr periferní krve u AML ukazuje myeloblast II. typu s Auerovou tyčí vpravo a lymfocyt vlevo. Description: Peripheral blood smear in AML shows II-nd type myeloblast with Auer rod at the right and lymphocyte at the left.
Type: peripheral blood
Klíčová slova*: myeloblast, lymphocyte, Auer rod
AML- peripheral blood
The II-nd type of myeloblast in AML; there are few fine azurophilic granules in cytoplasm at the right side of the nucleus. It contains three apparent nucleoli. Underneath of this cell is mature lymphocyte. / Myeloblast II. typu u AML, vpravo od jádra je v cytoplazmě několik azurofilních granulí. Jádro obsahuje tří zřetelná jadérka. Pod touto buňkou je zralý lymfocyt. Description: The II-nd type of myeloblast in AML; there are few fine azurophilic granules in cytoplasm at the right side of the nucleus. It contains three apparent nucleoli. Underneath of this cell is mature lymphocyte.
Type: peripheral blood
Klíčová slova*: myeloblast, lymphocyte