Small-cell bronchial carcinoma
Autor*: Monika Antošová, A. Buliková, J. Kissová
Description:
55-year old patient with established small cell lung carcinoma, simultaneously was manifested liver involvement.
Bone marrow evaluation was indicated due to bicytopenia - normocytic anemia with hemoglobin 103G/L and severe thrombocytopenia 11G/l. Smears showed massive tumour cells' infiltration.
Zařazení*:
Small-cell bronchial carcinoma
Přílohy*:
Small- cell bronchial carcinoma - BM
Description: Bone marrow smear in smaller enlargement - massive tumour cells' infiltration in clusters.
Type: bone marrow
Klíčová slova*: tumour cell
Small- cell bronchial carcinoma - BM
Description: The first example of the bone marrow infiltration in this case - the cluster of the middle size cells with narrow rim of basophilic cytoplasm; there is fine chromatin and some nucleoli in the nucleus. There is eosinophil metamyelocyte at the upper left, neutrophil metamyelocyte at the upper right and there are two late erythroblasts at the upper part of the picture. Naked nucleoli are the typical content of the smear.
Type: bone marrow
Klíčová slova*: metamyelocyte, orthochromatophilic normoblast, naked nucleus, tumour cell
Small- cell bronchial carcinoma - BM
Description: Tumour cells' infiltration of the bone marrow - cluster of smaller to middle size cells with high nucleus - cytoplasm ratio, there is fine chromatin in the nucleus with one to more nucleoli.
There is one hypergranular neutrophile myelocyte at left side, segmented neuthrophil with pseudo-pelgeroid appearance at the top and late erythroblast at the upper left, there are same naked nucleoli at the smear.
Type: bone marrow
Klíčová slova*: myelocyte, orthochromatophilic normoblast, hypergranulation, naked nucleus, tumour cell
Small - cell bronchial carcinoma - BM
Description: Tumour cells' infiltration - cluster of various size immature cells with narrow cytoplasm's rim, fine chromatin and nucleoli; there is late erythroblast at the upper right and there are some naked nucleoli at the smear.
Type: bone marrow
Klíčová slova*: orthochromatophilic normoblast, naked nucleus, tumour cell
Small- cell bronchial carcinoma - BM
Description: The last example bone marrow tumour cells' infiltration in this case - the cluster of various size tumour cells with immature appearance, narrow rim of basophilic cytoplasm and with fine chromatin and a few nucleoli in nucleus. There are two late erythroblasts at the left side of the picture.
Type: bone marrow
Klíčová slova*: polychromatophilic normoblast, orthochromatophilic normoblast, tumour cell